Projects per year
Personal profile
Research interests
The group of Wouter de Jonge studies mechanisms of functional and inflammatory gastro-intestinal disease.
-The pathogenesis of Inflammatory Bowel Diseases, through translational research and clinical trial analyses, including single cell sequencing and Mass Cytometry
-Preclinical research models for gastrointestinal Disease (IBD, irritable bowel syndrome (IBS), and motility disorders)
-Preclinical and Clinical research in surgical complications, wound healing and anastomotic healing
-Specialized medical nutrition to improve gut epithelial barriers and immunity - in alliance with industrial partners
-Epigenetic aspects of cell differentiation in the gut in health and disease
A link to my papers: https://www.ncbi.nlm.nih.gov/myncbi/161NjGEiygPkI/bibliography/public/
A link to my group website for all details: www.gut-research.com
And UKBonn: http://www.chirurgie-unibonn.de/forschung/immunpathophysiologie/
Group members:
faculty:
Seppen J.E. PhD
te Velde A.A. PhD
van den Wijngaard R.M. PhD
Hakvoort T.B.M. PhD
Sovran B. PhD
PhD students:
Becker M.A.J. MD
Brinkman D.J. MD
Chen H.J. MD
Deianova N. MD
de Krijger M. MD
Eeftinck Schattenkerk L.D. MD
Elfiky A.M.I.M. MD
Ghiboub M. MSc
Hageman I.L. MD
Joustra V.W. MD
Koopman N. Msc
Kreulen I.A.M. MSc
Luque Martin R.
Metselaar P.I. MSc
Peters E.G. MD
Pitotti G. MSc
Rahman S. MSc
ten Hove A.S. MD
van Helsdingen C.P.M. MD
van Thiel I.A.M. MSc
Wieser N.V. MSc
Fung I, Msc
Postdocs
Li Yim A.Y.F. MSc
Jan Verhoeff, Msc
Technical staff and facilies
Admiraal-van den Berg I. BSc
van Hamersveld H.P. BSc
Project and lab management:
Verseijden C. BSc
Welting O. MSc
specialisation
External positions
professor of NeuroGastroenterology, Universitaetsklinikum Bonn, Bonn, Germany
1 Jan 2018 → …
Collaborations and top research areas from the last five years
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METARYL: ZonMW and JPI: Tryptophan metabolism in obesity and T2Diabetes
1/04/2023 → 1/04/2027
Project: Research
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METHYLOMIC: Horizon Europe TOOL 11_05 Epigenetic Markers for IBD
1/04/2023 → 1/04/2027
Project: Research
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de Jonge W.J.: Gastro-Intestinal diseases
de Jonge, W., Heinsbroek, S., Seppen, J., van den Wijngaard, R., Zhao, J., van Leeuwen - Hilbers, F., Verseijden, C., Welting, O., Botschuijver, S., Brinkman, D., Chen, H., Dhawan, S., Duijvis, N., Ghiboub, M., ten Hove, A., de Krijger, M., Li Yim, A., Loring, S., Luque Martin, R., Peters, E., Schilderink, R., van Thiel, I., de Vries, L., Willemze, R. & Zhao, J.
1/09/2008 → …
Project: Research
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EPIC-CD
Li Yim, A., Hageman, I., Joustra, V., Satsangi, J., Henneman, P., de Jonge, W. & D' Haens, G.
1/01/2019 → 1/01/2023
Project: Research
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Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
van de Pavert, S. A., Olivier, B. J., Goverse, G., Vondenhoff, M. F. R., Greuter, M. J., Beke, P., Kusser, K., Hopken, U. E., Lipp, M., Niederreither, K., Blomhoff, R., Sitnik, K., Agace, W. W., Randall, TD., Jonge, W., Mebius, R. E., Höpken, U. E. & Randall, T. D., 2009, In: Nature immunology. 10, 11, p. 1193-1U78Research output: Contribution to journal › Article › Academic › peer-review
243 Citations (Scopus) -
Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2
van der Zanden, E. P., Snoek, S. A., Heinsbroek, S. E., Stanisor, O. I., Verseijden, C., Boeckxstaens, G. E., Peppelenbosch, M. P., Greaves, D. R., Gordon, S. & de Jonge, W. J., 2009, In: Gastroenterology. 137, 3, p. 1029-1039, 1039.e1-4Research output: Contribution to journal › Article › Academic › peer-review
116 Citations (Scopus) -
Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
de Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M. F., van Westerloo, D. J., Bennink, R. J., Berthoud, H-R., Uematsu, S., Akira, S., van den Wijngaard, R. M. & Boeckxstaens, G. E., 2005, In: Nature immunology. 6, 8, p. 844-851Research output: Contribution to journal › Article › Academic › peer-review
900 Citations (Scopus) -
Neural reflex pathways in intestinal inflammation: hypotheses to viable therapy
Willemze, R. A., Luyer, M. D., Buurman, W. A. & de Jonge, W. J., 2015, In: Nature reviews. Gastroenterology & hepatology. 12, 6, p. 353-362Research output: Contribution to journal › Review article › Academic › peer-review
34 Citations (Scopus) -
A new edge to immune surveillance by the neural system
Bernink, J. H., Spits, H. & de Jonge, W. J., 2016, In: Cell research. 26, 11, p. 1178-1179Research output: Contribution to journal › Editorial › Academic › peer-review
2 Citations (Scopus)
Datasets
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Additional file 15 of Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140
Ghiboub, M. (Creator), Koster, J. (Creator), Craggs, P. D. (Creator), Li Yim, A. (Creator), Shillings, A. (Creator), Hutchinson, S. (Creator), Bingham, R. P. (Creator), Gatfield, K. (Creator), Hageman, I. L. (Creator), Yao, G. (Creator), O’Keefe, H. P. (Creator), Coffin, A. (Creator), Patel, A. (Creator), Sloan, L. A. (Creator), Mitchell, D. J. (Creator), Hayhow, T. G. (Creator), Lunven, L. (Creator), Watson, R. J. (Creator), Blunt, C. E. (Creator), Harrison, L. A. (Creator), Bruton, G. (Creator), Kumar, U. (Creator), Hamer, N. (Creator), Spaull, J. R. (Creator), Zwijnenburg, D. A. (Creator), Welting, O. (Creator), Hakvoort, T. B. M. (Creator), te Velde, A. (Creator), van Limbergen, J. (Creator), Henneman, P. (Creator), Prinjha, R. K. (Creator), de Winther, M. (Creator), Harker, N. R. (Creator), Tough, D. F. (Creator), de Jonge, W. (Creator), Coffin, A. (Creator), van Limbergen, J. (Creator) & Harker, N. R. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.20521114.v1, https://springernature.figshare.com/articles/dataset/Additional_file_15_of_Modulation_of_macrophage_inflammatory_function_through_selective_inhibition_of_the_epigenetic_reader_protein_SP140/20521114/1
Dataset
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Additional file 10 of Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140
Ghiboub, M. (Creator), Koster, J. (Creator), Craggs, P. D. (Creator), Li Yim, A. (Creator), Shillings, A. (Creator), Hutchinson, S. (Creator), Bingham, R. P. (Creator), Gatfield, K. (Creator), Hageman, I. L. (Creator), Yao, G. (Creator), O’Keefe, H. P. (Creator), Coffin, A. (Creator), Patel, A. (Creator), Sloan, L. A. (Creator), Mitchell, D. J. (Creator), Hayhow, T. G. (Creator), Lunven, L. (Creator), Watson, R. J. (Creator), Blunt, C. E. (Creator), Harrison, L. A. (Creator), Bruton, G. (Creator), Kumar, U. (Creator), Hamer, N. (Creator), Spaull, J. R. (Creator), Zwijnenburg, D. A. (Creator), Welting, O. (Creator), Hakvoort, T. B. M. (Creator), te Velde, A. (Creator), van Limbergen, J. (Creator), Henneman, P. (Creator), Prinjha, R. K. (Creator), de Winther, M. (Creator), Harker, N. R. (Creator), Tough, D. F. (Creator), de Jonge, W. (Creator), Coffin, A. (Creator), van Limbergen, J. (Creator) & Harker, N. R. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.20521093.v1, https://springernature.figshare.com/articles/dataset/Additional_file_10_of_Modulation_of_macrophage_inflammatory_function_through_selective_inhibition_of_the_epigenetic_reader_protein_SP140/20521093/1
Dataset
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Additional file 14 of Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140
Ghiboub, M. (Creator), Koster, J. (Creator), Craggs, P. D. (Creator), Li Yim, A. (Creator), Shillings, A. (Creator), Hutchinson, S. (Creator), Bingham, R. P. (Creator), Gatfield, K. (Creator), Hageman, I. L. (Creator), Yao, G. (Creator), O’Keefe, H. P. (Creator), Coffin, A. (Creator), Patel, A. (Creator), Sloan, L. A. (Creator), Mitchell, D. J. (Creator), Hayhow, T. G. (Creator), Lunven, L. (Creator), Watson, R. J. (Creator), Blunt, C. E. (Creator), Harrison, L. A. (Creator), Bruton, G. (Creator), Kumar, U. (Creator), Hamer, N. (Creator), Spaull, J. R. (Creator), Zwijnenburg, D. A. (Creator), Welting, O. (Creator), Hakvoort, T. B. M. (Creator), te Velde, A. (Creator), van Limbergen, J. (Creator), Henneman, P. (Creator), Prinjha, R. K. (Creator), de Winther, M. (Creator), Harker, N. R. (Creator), Tough, D. F. (Creator), de Jonge, W. (Creator), Coffin, A. (Creator), van Limbergen, J. (Creator) & Harker, N. R. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.20521111, https://springernature.figshare.com/articles/dataset/Additional_file_14_of_Modulation_of_macrophage_inflammatory_function_through_selective_inhibition_of_the_epigenetic_reader_protein_SP140/20521111
Dataset
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Additional file 7: Table S5. of Peripheral blood methylation profiling of female Crohn’s disease patients
Li Yim, A. (Contributor), Duijvis, N. W. (Creator), Zhao, J. (Creator), de Jonge, W. (Contributor), D' Haens, G. (Creator), Mannens, M. (Creator), Mul, A. N. P. M. (Creator), te Velde, A. (Contributor), Henneman, P. (Creator), D' Haens, G. (Creator) & Mannens, M. (Creator), Figshare, 2016
DOI: 10.6084/m9.figshare.c.3620078_d1.v1, https://springernature.figshare.com/articles/dataset/Additional_file_7_Table_S5_of_Peripheral_blood_methylation_profiling_of_female_Crohn_s_disease_patients/4391117/1
Dataset
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Additional file 7: Table S5. of Peripheral blood methylation profiling of female Crohn’s disease patients
Li Yim, A. (Contributor), Duijvis, N. W. (Creator), Zhao, J. (Creator), de Jonge, W. (Contributor), D' Haens, G. (Creator), Mannens, M. (Creator), Mul, A. N. P. M. (Creator), te Velde, A. (Contributor), Henneman, P. (Creator) & Mannens, M. (Creator), Figshare, 2016
DOI: 10.6084/m9.figshare.c.3620078_d1, https://springernature.figshare.com/articles/dataset/Additional_file_7_Table_S5_of_Peripheral_blood_methylation_profiling_of_female_Crohn_s_disease_patients/4391117
Dataset
Prizes
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CSO
Wouter J. de Jonge (Consultant) & Ross Gordon (Advisor)
1 May 2023Activity: Consultancy › Professional
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University of Bonn
Wouter J. de Jonge (Visiting researcher)
1 Jan 2018 → 1 Jan 2025Activity: Visiting an external institution › Visiting an external academic institution › Academic