Projects per year
Substance use disorders and behavioral addictions are the conseqence of a negative interaction between blogical, psychological and social factors. As they come into existence they are best regarded as brain disorders. Our mission is to conduct patient-centered addiction research resulting in better- evidence based treatments for patients with addictive disorders. We try to achieve this goal through development and testing of effective and efficient treatments and exploration of mechanisms underlying treatment success. Emphasis is on clinical research, but recently we initiated pre-clinical studies to pilot new interventions and to enhance our understanding of tretament processes.
We distinghish three (overlapping) themes:
(1) Basic neurbiological research investigating factors involved in the initiation and persistance of addictive behaviours, e.g. neurobiology of craving, neurocognitive deficits associated with pathological gambling, neurobiological predicors of treatment success. One of our main technologies here is neuroimaging (SPECT, fMRI, DTI, H.MRS).
(2) Treatment research, testing the effectiveness of addiction treatments and their underlying processes, e.g. treatment efficacy, process evaluation, double diagnosis treatmentss, and patient-treatment matching (pharmacogenomics). A recent interest is the study of neuromodulation techniques: transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS).
(3) Health services research, investigating healthcare systems, e.g. implementation of evidence-based interventions, quality of health care, cost-effectiveness.
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- 1 Active
van den Brink W.: Addiction: pathogenesis, mechanisms of relapse and treatment effectiveness
van den Brink, W., Derks, E., Lok, A., Goudriaan, A., Berends, I., Drost, L., Gomes, T., Nuijten, M., Nurhidayat, A., van Oortmerssen, K., Raposo Pereira, F., Rutten, R., Schulte, M., de Waal, M., Berendsen, H. A., Boersma, N., Kronenberg, L., Liebregts, N., Matthys, F. & de Vries, G.
1/07/2006 → …
Extending the treatment options in alcohol dependence: a randomized controlled study of as-needed nalmefeneMann, K., Bladström, A., Torup, L., Gual, A. & van den Brink, W., 2013, In: Biological Psychiatry. 73, 8, p. 706-713
Research output: Contribution to journal › Article › Academic › peer-review269 Citations (Scopus)
Effect of alcohol use on the course of bipolar disorder: one-year follow-up study using the daily prospective Life Chart methodvan Zaane, J., van de Ven, P. M., Draisma, S., Smit, J. H., Nolen, W. A. & van den Brink, W., 2014, In: Bipolar disorders. 16, 4, p. 400-409
Research output: Contribution to journal › Article › Academic › peer-review6 Citations (Scopus)
Wim van den Brink and colleagues reply to Des Spence and Alain Braillonvan den Brink, W., Mann, K., Gual, A. & Aubin, H-J., 2014, In: BMJ (Clinical research ed.). 348, p. g2605
Research output: Contribution to journal › Comment/Letter to the editor › Academic3 Citations (Scopus)
Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacyMann, K., Torup, L., Sørensen, P., Gual, A., Swift, R., Walker, B. & van den Brink, W., 2016, In: European neuropsychopharmacology. 26, 12, p. 1941-1949
Research output: Contribution to journal › Review article › Academic › peer-review57 Citations (Scopus)
Predictive validity of a culturally informed diagnosis of schizophrenia: a 30 month follow-up study with first episode psychosisZandi, T., Havenaar, J. M., Laan, W., Kahn, R. S. & van den Brink, W., 2011, In: Schizophrenia Research. 133, 1-3, p. 29-35
Research output: Contribution to journal › Article › Academic › peer-review14 Citations (Scopus)
Effect of modafinil on cognitive functions in alcohol dependent patients: A randomized, placebo-controlled trial
van den Brink, W. (Contributor), Goudriaan, A. (Contributor), Joos, L. (Contributor), Dom, G. (Contributor), Schmaal, L. (Contributor) & Sabbe, B. G. C. (Contributor), figshare SAGE Publications, 1 Nov 2013
DOI: 10.25384/sage.c.5066376.v1, https://doi.org/10.25384%2Fsage.c.5066376.v1
Supplemental Material, JOP503505_-_Supplementary_material – Effect of modafinil on cognitive functions in alcohol dependent patients: A randomized, placebo-controlled trial
Goudriaan, A. (Contributor), van den Brink, W. (Contributor), Sabbe, B. G. C. (Contributor), Schmaal, L. (Contributor), Joos, L. (Contributor) & Dom, G. (Contributor), figshare SAGE Publications, 1 Nov 2013
DOI: 10.25384/sage.12670863.v1, https://doi.org/10.25384%2Fsage.12670863.v1