Wytske Fokkens

(Principal Investigator), Prof. PhD

1979 …2023

Research activity per year

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Personal profile

Research interests

  Main field of interest is sinus and skull base surgery and mucosal pathology of the upper and lower airways.

Chronic Rhinosinusitis and Nasal Polyps: From epidemiology via system biology to new treatments.
Further to the GA2LEN network we will investigate differences in disease expression between ethnic groups in a cohort of 8000 patients and will further participate in the Helius study. We will identify disease mechanisms and develop new treatments for difficult to treat cases with some new options currently under evaluation. In a national multicenter trial we aim to compare efficacy of surgery versus medical treatment (ZonMw). The new possibilities of biologicals are investigated.

Non-allergic rhinitis: From pathophysiology to new treatments.
Around 10% of the European population suffers from NAR with effective treatment only available for few individuals as the aetiology is often unknown. Phenotyping NAR in a clinical and laboratory setting has led to a new treatment option, with a second in development together with pharmaceutical partners.

Allergic rhinitis: Towards personalized treatment
We have shown that different allergen sensitizations have different clinical outcomes that affects treatment in individual patients and corroborated this by laboratory studies. In an international IMI consortium (UBIOPRED) on severe lower respiratory diseases we will search for molecular handprints for the relationships of upper and lower airway and in a new EU trial (BM4SIT) we will evaluate personalized immunotherapy.



Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
  • European Position Paper on Rhinosinusitis and Nasal Polyps 2020

    Fokkens, W. J., Lund, V. J., Hopkins, C., Hellings, P. W., Kern, R., Reitsma, S., Toppila-Salmi, S., Bernal-Sprekelsen, M., Mullol, J., Alobid, I., Terezinha Anselmo-Lima, W., Bachert, C., Baroody, F., von Buchwald, C., Cervin, A., Cohen, N., Constantinidis, J., de Gabory, L., Desrosiers, M., Diamant, Z., & 108 othersDouglas, R. G., Gevaert, P. H., Hafner, A., Harvey, R. J., Joos, G. F., Kalogjera, L., Knill, A., Kocks, J. H., Landis, B. N., Limpens, J., Lebeer, S., Lourenco, O., Matricardi, P. M., Meco, C., O Mahony, L., Philpott, C. M., Ryan, D., Schlosser, R., Senior, B., Smith, T. L., Teeling, T., Tomazic, P. V., Wang, D. Y., Wang, D., Zhang, L., Agius, A. M., Ahlstrom-Emanuelsson, C., Alabri, R., Albu, S., Alhabash, S., Aleksic, A., Aloulah, M., Al-Qudah, M., Alsaleh, S., Baban, M. A., Baudoin, T., Balvers, T., Battaglia, T., Bedoya, J. D., Beule, A., Bofares, K. M., Braverman, I., Brozek-Madry, E., Richard, B., Callejas, C., Carrie, S., Caulley, L., Chussi, D., de Corso, E., Coste, A., Devyani, L., el Hadi, U., Elfarouk, A., Eloy, P. H., Farrokhi, S., Felisati, G., Ferrari, M. D., Fishchuk, R., Grayson, W., Goncalves, P. M., Grdinic, B., Grgic, V., Hamizan, A. W., Heinichen, J. V., Husain, S., Ping, T. I., Ivaska, J., Jakimovska, F., Jovancevic, L., Kakande, E., Kamel, R., Karpischenko, S., Kariyawasam, H. H., Kjeldsen, A., Klimek, L., Kim, S. W., Letort, J. J., Lopatin, A., Mahdjoubi, A., Netkovski, J., Nyenbue Tshipukane, D., Obando-Valverde, A., Okano, M., Onerci, M., Ong, Y. K., Orlandi, R., Ouennoughy, K., Ozkan, M., Peric, A., Plzak, J., Prokopakis, E., Prepageran, N., Psaltis, A., Pugin, B., Raftopulos, M., Rombaux, P., Sahtout, S., Sarafoleanu, C. C., Searyoh, K., Rhee, C. S., Shi, J., Shkoukani, M., Shukuryan, A. K., Sicak, M., Smyth, D., Snidvongs, K., Soklic Kosak, T. & Stjarne, P., 20 Feb 2020, In: Rhinology. 58, p. 1-464 464 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    1344 Citations (Scopus)
  • EUFOREA consensus on biologics for CRSwNP with or without asthma

    Fokkens, W. J., Lund, V., Bachert, C., Mullol, J., Bjermer, L., Bousquet, J., Canonica, G. W., Deneyer, L., Desrosiers, M., Diamant, Z., Han, J., Heffler, E., Hopkins, C., Jankowski, R., Joos, G., Knill, A., Lee, J., Lee, S. E., Mariën, G., Pugin, B., & 3 othersSenior, B., Seys, S. F. & Hellings, P. W., Dec 2019, In: Allergy. 74, 12, p. 2312-2319

    Research output: Contribution to journalReview articleAcademicpeer-review

    Open Access
    196 Citations (Scopus)
  • IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

    Bal, S. M., Bernink, J. H., Nagasawa, M., Groot, J., Shikhagaie, M. M., Golebski, K., van Drunen, C. M., Lutter, R., Jonkers, R. E., Hombrink, P., Bruchard, M., Villaudy, J., Munneke, J. M., Fokkens, W., Erjefält, J. S., Spits, H. & Ros, X. R., 2016, In: Nature immunology. 17, 6, p. 636-645

    Research output: Contribution to journalArticleAcademicpeer-review

    346 Citations (Scopus)
  • Avoid prescribing antibiotics in acute rhinosinusitis

    Fokkens, W. J., Hoffmans, R. & Thomas, M., 2014, In: BMJ (Clinical research ed.). 349, p. g5703

    Research output: Contribution to journalEditorialAcademicpeer-review

    15 Citations (Scopus)
  • Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials

    Bachert, C., Han, J. K., Desrosiers, M., Hellings, P. W., Amin, N., Lee, S. E., Mullol, J., Greos, L. S., Bosso, J. V., Laidlaw, T. M., Cervin, A. U., Maspero, J. F., Hopkins, C., Olze, H., Canonica, G. W., Paggiaro, P., Cho, S. H., Fokkens, W. J., Fujieda, S., Zhang, M., & 14 othersLu, X., Fan, C., Draikiwicz, S., Kamat, S. A., Khan, A., Pirozzi, G., Patel, N., Graham, N. M. H., Ruddy, M., Staudinger, H., Weinreich, D., Stahl, N., Yancopoulos, G. D. & Mannent, L. P., 2 Nov 2019, In: Lancet. 394, 10209, p. 1638-1650 13 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    702 Citations (Scopus)