Projects per year
Personal profile
specialisation
Psychiatric Epidemiology
Research interests
I studied and trained in clinical psychology and psychotherapy in Italy. Subsequently, I worked in the field of epidemiology of aging in Italy (InCHIANTI Study 2007-2010) and the USA (National Institute of Aging, 2010-2012). Due to the enriching experience in such diverse contexts my research perspective became inherently multidisciplinary. My main research theme is the study, using the tools of epidemiology, of biological pathways that may have a role in the pathophysiology of depression.
At the Department of Psychiatry of Amsterdam UMC, where I am currently assistant professor of psychiatry and epidemiology, I further developed the investigation of the immuno-metabolic biological pathways involved in depression. Furthermore, I embraced the exciting developments of the genomics era, expanding my skills and moving my research questions beyond the study of biomarkers of depression toward its genetic basis. I wrote invited expert reviews on genetic research in depression, the biological mechanisms connecting depression and obesity and, more recently, presenting the concept of “Immuno-Metabolic Depression”
I am currently member of the The Scientific Quality Committee (SQC) of Amsterdam Public Health and co-PI of the new INFLAMED trial testing anti-inflammatory add-on in the treatment of Immuno-Metabolic Depression
Ancillary activities
No ancillary activities
Ancillary activities are updated daily
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 2 Active
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inflaMED: Precision psychiatry: Anti-inflammatory medication in Immuno-metabolic depression
Lamers, F., Milaneschi, Y., Penninx, B., Vinkers, C. & Zwiep, J.
1/09/2021 → 31/08/2025
Project: Research
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PERCIM: Personalized Care for Depression: Bringing Immuno-Metabolic Depression from Bench to Bedside
Lamers, F., Jansen, R., Vreijling, S., Penninx, B., Beekman, A., Bot, M., Milaneschi, Y., Bremmer, M. & Rhebergen, D.
1/10/2019 → 30/04/2024
Project: Research
Research output
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Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression
Milaneschi, Y., Lamers, F., Berk, M. & Penninx, B. W. J. H., 1 Sept 2020, In: Biological Psychiatry. 88, 5, p. 369-380 12 p.Research output: Contribution to journal › Review article › Academic › peer-review
170 Citations (Scopus) -
Depression and obesity: evidence of shared biological mechanisms
Milaneschi, Y., Simmons, W. K., van Rossum, E. F. C. & Penninx, B. WJH., 1 Jan 2019, In: Molecular psychiatry. 24, 1, p. 18-33 16 p.Research output: Contribution to journal › Review article › Academic › peer-review
463 Citations (Scopus) -
Metabolomics dissection of depression heterogeneity and related cardiometabolic risk
Alshehri, T., Mook- Kanamori, D. O., Willems van Dijk, K., Dinga, R., Penninx, B. W. J. H., Rosendaal, F. R., le Cessie, S. & Milaneschi, Y., 3 Jan 2023, In: Psychological Medicine. 53, 1, p. 248-257 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access4 Citations (Scopus) -
Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity
Mbarek, H., Gordon, S. D., Duffy, D. L., Hubers, N., Mortlock, S., Beck, J. J., Hottenga, J-J., Pool, R., Dolan, C. V., Actkins, K. V., Gerring, Z. F., van Dongen, J., Ehli, E. A., Iacono, W. G., Mcgue, M., Chasman, D. I., Gallagher, C. S., Schilit, S. L. P., Morton, C. C., Paré, G., & 38 others , 1 Jan 2024, In: Human Reproduction. 39, 1, p. 240-257 18 p., dead247.Research output: Contribution to journal › Article › Academic › peer-review
Open Access2 Citations (Scopus) -
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
Scholz, M., Horn, K., Pott, J., Wuttke, M., Kühnapfel, A., Nasr, M. K., Kirsten, H., Li, Y., Hoppmann, A., Gorski, M., Ghasemi, S., Li, M., Tin, A., Chai, J-F., Cocca, M., Wang, J., Nutile, T., Akiyama, M., Åsvold, B. O., Bansal, N., & 139 others , 1 Dec 2024, In: Nature communications. 15, 1, 586.Research output: Contribution to journal › Article › Academic › peer-review
Open Access