Projects per year
Personal profile
Research interests
Yvette van Kooyk is professor in Molecular Cell Biology and Immunology, head of the department Molecular Cell Biology and Immunology, PI of the Dendritic Cell Immunobiology group and co-director of the Amsterdam institute for Infection and Immunity (AII).
Van Kooyk’s research team studies innate and adaptive immune responses guided by glycosylation. Her team unravels cellular communication driven by modified glycoproteins/lipids in cancer, allergy and autoimmunity. Central in her work is the development of new glycan modified immune therapy for cancer and allergy, targeting glycan binding receptors on skin resident antigens presenting cells that induce or inhibit immunity.
Her second line of research is aimed to discover of glycan imposed regulatory immune imprinting by inflamed tissue and tumor microenvironment. She studies these questions in in-vivo mouse tumor models such as pancreatic cancer, lung, colon and melanoma in patient derived tissues and human in-vitro models such as skin model, tumor tissues and complex 3D culture models to identify cellular communication at omics level in the context of tissue alterations.
She was awarded various NWO grants (PIONIER-ASPASIA), ERC Advanced-Eurostars and received the SPINOZA and van Loghem award for life time achievements in field of (Glyco)-Immunology, and is a member of the Royal Netherlands Academy of Sciences (KNAW).
specialisation
Molecular Cell Biology and Immunology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 1 Active
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FUCOSYLATED GLYCAN EPITOPES AS NOVEL IMMUNE CHECKPOINT MOLECULES IN COLORECTAL CANCER
van Vliet, S., van Kooyk, Y., van Egmond, M. & Hatinguais, R.
1/06/2023 → 31/05/2026
Project: Research
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Deciphering the Chemical Language of the Immunomodulatory Properties of Veillonella parvula Lipopolysaccharide
Pither, M. D., Andretta, E., Rocca, G., Balzarini, F., Matamoros-Recio, A., Colicchio, R., Salvatore, P., van Kooyk, Y., Silipo, A., Granucci, F., Martin-Santamaria, S., Chiodo, F., Molinaro, A. & di Lorenzo, F., 2024, (E-pub ahead of print) In: Angewandte Chemie - International Edition.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions
Boelaars, K., Rodriguez, E., Huinen, Z. R., Liu, C., Wang, D., Springer, B. O., Olesek, K., Goossens-Kruijssen, L., van Ee, T., Lindijer, D., Tak, W., de Haas, A., Wehry, L., Nugteren-Boogaard, J. P., Mikula, A., de Winde, C. M., Mebius, R. E., Tuveson, D. A., Giovannetti, E., Bijlsma, M. F., & 3 others , 9 Apr 2024, In: Communications Biology. 7, 1, p. 430Research output: Contribution to journal › Article › Academic › peer-review
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Sialic acid–modified der p 2 allergen exerts immunomodulatory effects on human PBMCs
Keumatio Doungtsop, B-C., Nardini, E., Kalay, H., Versteeg, S. A., Lübbers, J., van Barneveld, G., Li, E. R. J., van Vliet, S. J., van Ree, R., de Jong, E. C. & van Kooyk, Y., 1 Feb 2024, In: Journal of Allergy and Clinical Immunology: Global. 3, 1, p. 100193 100193.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Targeting myeloid cells for cancer immunotherapy: Siglec-7/9/10/15 and their ligands
Boelaars, K. & van Kooyk, Y., Mar 2024, In: Trends in Cancer. 10, 3, p. 230-241 12 p.Research output: Contribution to journal › Review article › Academic › peer-review
Open Access -
The immunological landscape of peripheral blood in glioblastoma patients and immunological consequences of age and dexamethasone treatment
Dusoswa, S. A., Verhoeff, J., van Asten, S., Lübbers, J., van den Braber, M., Peters, S., Abeln, S., Crommentuijn, M. H. W., Wesseling, P., Vandertop, W. P., Twisk, J. W. R., Würdinger, T., Noske, D., van Kooyk, Y. & Garcia-Vallejo, J. J., 2024, In: Frontiers in immunology. 15, p. 1343484 1343484.Research output: Contribution to journal › Article › Academic › peer-review
Open Access
Activities
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The sialic acid-Siglec axis in oral tolerance
Yvette van Kooyk (Keynote speaker)
29 May 2023Activity: Lecture / Presentation › Invited talk › Academic
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Academia Europea (External organisation)
Yvette van Kooyk (Chair)
20 May 2023Activity: Membership › Membership of committee › Academic
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Sialic acids, siglec interactions, novel immune checkpoint
Yvette van Kooyk (Speaker)
14 Apr 2023 → 24 Apr 2023Activity: Lecture / Presentation › Invited talk › Academic
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ERC-SyG (External organisation)
Yvette van Kooyk (Chair)
2022 → …Activity: Membership › Membership of committee › Academic
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The Glycocode in cancer
Yvette van Kooyk (Speaker)
1 Oct 2022Activity: Lecture / Presentation › Invited talk › Academic
Press/Media
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Dag van de vrouwen. Over het onderzoek in immunologie (glyco-immunologie) van Yvette en de impact voor maatschappij.
1/01/2020
1 Media contribution
Press/Media: Interview
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Suikerstructuren functioneren als immuuncheckpoint bij kanker
2/12/2019
1 Media contribution
Press/Media: Interview
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Spinozaprijs voor pionier in de glyco-immunologie
1/12/2019
1 Media contribution
Press/Media: Interview
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De sleutelrol van suikers bij het immuunsysteem
2/10/2019
1 item of Media coverage
Press/Media: Interview