Bel A.: Image guided and adaptive radiotherapy

  • Bel, Adrianus (Principal investigator)
  • Alderliesten, Tanja (Staff)
  • Crezee, Johannes (Staff)
  • van Dijk, Irma (Staff)
  • van der Horst, Astrid (PostDoc)
  • Bosman, Peter (Other)
  • de Boer, Peter (Internal PhD candidate)
  • Gurney-Champion, Oliver (Internal PhD candidate)
  • van Heerden, Laura (Internal PhD candidate)
  • Huijskens, Sophie (Internal PhD candidate)
  • Jin, Peng (Internal PhD candidate)
  • van Leeuwen, Caspar (Internal PhD candidate)
  • Lens, Eelco (Internal PhD candidate)
  • Wang, Ziyuan (Internal PhD candidate)

Project Details

Description

Image guidance is essential for high-precision dose delivery in radiotherapy. It comprises the pre-treatment localization of the target with CT and/or MRI as well as safeguarding patient positioning during treatment. Especially the introduction of the linac mounted Cone Beam CT has opened a new realm of possibilities to enhance treatment precision, including:

* Localization of mobile tumors and organs-at-risk.
* Improvement of visualization of the relevant anatomy by application of markers in or around the tumor.
* Bio-mechanical modeling of the internal anatomy.
* Strategies for geometrical and dosimetric corrections of the treatment, including adaptive radiotherapy ( ART).

Focus is on mobile gastrointestinal/abdominal tumors (pancreatic, bladder and esophagus).
Moreover, external beam radiotherapy is combined with other techniques:

* Brachytherapy: the tumor is irradiated locally with a radioactive source
* Hyperthermia: the effect of irradiation is enhanced by heating.

Research includes modeling and quantification of the synergistic effect of these combinations.
StatusActive
Effective start/end date1/01/2013 → …