Spaargaren M.: Molecular pathogenesis and targeted therapy of B cell malignancies

Project Details


Our research group (Dept. of Pathology, section Immuno- and Hematopathology) has a long-standing interest in the molecular and cellular aspects of normal B cell differentiation and function, and in the pathogenesis of B-cell malignancies, in particular Non-Hodgkin Lymphoma (NHL), Chronic Lymphocytic Leukemia (CLL) and Multiple Myeloma (MM).

As a PI in the AMC I participate in the major research themes “Oncology” and “Immunity and Infection” and as such in the Oncologic Research Center AMC (ORCA) and the Center for Immunology Amsterdam (CIA).

The major themes of my current research are "Growth and differentiation of normal and malignant B cells" and "Cell adhesion and migration in immunity and cancer". In this context, our aims are:
1) identify and molecularly dissect the signaling pathways involved in differentiation and function of B cells and in the pathogenesis of B-cell malignancies;
2) explore and exploit the microenvironment-dependence as the Achilles’ heel of B-cell malignancies

More specifically, regarding these themes and aims, we explore(d) the molecular and functional aspects of signalling by the B-cell antigen receptor, chemokines (e.g. CXCL12/CXCR4), receptor tyrosine kinases (e.g., HGF/MET), and WNTs, and the role of heparan sulfate proteoglycans, adhesion molecules (integrins and cadherins), GTPases (e.g., Ras and Ral), kinases (e.g., Bruton’s tyrosine kinase (BTK) and PI3K), and the transcription factor FOXP1.

Themes: Oncology, Infection and Immunity

This research group participates in ORCA (Oncologic Research Center AMC) and CIA (Center for Immunology Amsterdam)
Effective start/end date1/01/2007 → …