Spek C.A.: Blood coagulation in pathophysiology

Project Details


The Blood Coagulation Research Program of CEMM aims at investigating fundamental mechanisms by which individual coagulation factors affect wound healing, fibrosis, cancer cell metastasis and inflammation. The primary aim of the program is to fully appreciate blood coagulation factor protease-activated receptor (PAR) signaling in pathophysiology.

The program utilizes a multidisciplinary approach to address relevant questions at a both the cellular and molecular level. This approach encompasses all aspects of modern molecular biology, including in vitro signal transduction studies, in vivo studies using transgenic mice, cell biology and gene expression analysis.

Current projects within the program are:

* Blood coagulation and the fate of circulating cancer cells.
* Blood coagulation factor driven protease-activated receptor signaling in pancreatic cancer.
* PAR1 and PAR-2 in pulmonary fibrosis.
* Preventing Scar formation by targeting coagulation-dependent Protease Activated Receptor activation.
* The molecular mechanism by which CEBPdelta is protective in inflammatory disease.
* Diabetic nephropathy: Mechanistic insight in the role of protease activated receptor 1.
* Bone marrow fibrosis: therapeutic role of protease activated receptor inhibition?
Effective start/end date1/01/2007 → …