van Noorden C.J.F.: Cancer metabolism

  • Arik - Yetkin, Bahar (Internal PhD candidate)
  • Dallinga, Marchien (Internal PhD candidate)
  • Hira, Vashendriya (Internal PhD candidate)
  • Jadczak, Anna Elisabeth (Internal PhD candidate)
  • Jansen, Anne (Internal PhD candidate)
  • Khurshed, Mohammed (Internal PhD candidate)
  • Krishnaswami, Venkataraman (Internal PhD candidate)
  • Molenaar, Remco (Internal PhD candidate)
  • Ramos de Carvalho, Emanuel (Internal PhD candidate)
  • Steudel, Christina Henrike (Internal PhD candidate)
  • Verma, Jyoti (Internal PhD candidate)
  • Vriend, Lianne (Internal PhD candidate)
  • van der Wijk, Anne (Internal PhD candidate)
  • van Noorden, Ron (Principal investigator)

Project Details


Glioblastoma research is focussed on energy metabolism because we have strong indications that the Warburg effect does not apply to glioblastoma. Mitochondrial glutamine/glutamate catabolism seems to be important as energy source in cancer cells. Furthermore, the mutation in the genes of the metabolic enzymes NADP-dependent isocitrate dehydrogenase (IDH) 1 and 2 was found to be linked with prolonged survival of secondary glioblastoma patients. With the use of quantitative histochemical means, we investigate molecular mechanisms of the prolonged survival.
Effective start/end date1/06/2013 → …