van Noorden C.J.F.: Cancer metabolism

  • Arik - Yetkin, Bahar (Internal PhD candidate)
  • Dallinga, Marchien (Internal PhD candidate)
  • Hira, Vashendriya (Internal PhD candidate)
  • Jadczak, Anna Elisabeth (Internal PhD candidate)
  • Jansen, Anne (Internal PhD candidate)
  • Khurshed, Mohammed (Internal PhD candidate)
  • Krishnaswami, Venkataraman (Internal PhD candidate)
  • Molenaar, Remco (Internal PhD candidate)
  • Ramos de Carvalho, Emanuel (Internal PhD candidate)
  • Steudel, Christina Henrike (Internal PhD candidate)
  • Verma, Jyoti (Internal PhD candidate)
  • Vriend, Lianne (Internal PhD candidate)
  • van der Wijk, Anne (Internal PhD candidate)
  • van Noorden, Ron (Principal investigator)

Project Details

Description

Glioblastoma research is focussed on energy metabolism because we have strong indications that the Warburg effect does not apply to glioblastoma. Mitochondrial glutamine/glutamate catabolism seems to be important as energy source in cancer cells. Furthermore, the mutation in the genes of the metabolic enzymes NADP-dependent isocitrate dehydrogenase (IDH) 1 and 2 was found to be linked with prolonged survival of secondary glioblastoma patients. With the use of quantitative histochemical means, we investigate molecular mechanisms of the prolonged survival.
StatusActive
Effective start/end date1/06/2013 → …