Wilde A.A.M.: Clinical aspects of heart failure and arrhythmias

The project aimed to identify disease-causing genes and to unravel the pathophysiological basis of inherited cardiac diseases. The focus was placed on genotype-phenotype studies in different cardiomyopathies, among which hypertrophic cardiomyopathy and arrhythmogenic cardiomyopathy, and in primary arrhythmias syndromes (Long QT syndrome, Brugada syndrome). Diverse genetic aspects of the Long QT syndrome were also addressed. In addition, the focus was shifted towards the role of more frequently occurring genetic aberrancies on electrocardiographic parameters. Finally, we continued to sample patients with ischemia-induced ‘primary’ VF and demonstrated that a strong genetic component is involved.

Theme: Cardiovascular Diseases


This research group participates in the Heart Failure Research Centre