TY - JOUR
T1 - Brain activation during an emotional task in participants with PTSD and borderline and/or cluster C personality disorders
AU - Aarts, Inga
AU - Vriend, Chris
AU - van den Heuvel, Odile A
AU - Thomaes, Kathleen
N1 - Funding Information: This project was funded by a grant from the Steunfonds Joodse GGZ. Funding Information: Participant recruitment was accomplished through Hersenonderzoek.nl, a Dutch online registry that facilitates participant recruitment for neuroscience studies (www.hersenonderzoek.nl). Hersenonderzoek.nl is funded by ZonMw-Memorabel (project no 73305095003), a project in the context of the Dutch Deltaplan Dementie, the Alzheimer’s Society in the Netherlands and Brain Foundation Netherlands. Publisher Copyright: © 2023 The Authors
PY - 2024/1
Y1 - 2024/1
N2 - INTRODUCTION: Although comorbidity of post-traumatic stress disorder (PTSD) with borderline personality disorder (BPD) and/or cluster C personality disorders (CPD) is common, neural correlates of this comorbidity are unknown.METHODS: We acquired functional MRI scans during an emotional face task in participants with PTSD + CPD (n = 34), PTSD + BPD (n = 24), PTSD + BPD + CPD (n = 18) and controls (n = 30). We used ANCOVAs and Bayesian analyses on specific ROIs in a fearful vs. scrambled faces contrast. We also investigated associations with clinical measures.RESULTS: There were no robust differences in brain activation between the groups with ANCOVAs. Transdiagnostically, we found a negative association between severity of dissociation and right insula and right dmPFC activation, and emotion regulation problems with right dmPFC activation. Bayesian analyses showed credible evidence for higher activation in all ROIs in the PTSD + BPD + CPD group compared to PTSD + BPD and PTSD + CPD.DISCUSSION: Our Bayesian and correlation analyses support new dimensional conceptualizations of personality disorders.
AB - INTRODUCTION: Although comorbidity of post-traumatic stress disorder (PTSD) with borderline personality disorder (BPD) and/or cluster C personality disorders (CPD) is common, neural correlates of this comorbidity are unknown.METHODS: We acquired functional MRI scans during an emotional face task in participants with PTSD + CPD (n = 34), PTSD + BPD (n = 24), PTSD + BPD + CPD (n = 18) and controls (n = 30). We used ANCOVAs and Bayesian analyses on specific ROIs in a fearful vs. scrambled faces contrast. We also investigated associations with clinical measures.RESULTS: There were no robust differences in brain activation between the groups with ANCOVAs. Transdiagnostically, we found a negative association between severity of dissociation and right insula and right dmPFC activation, and emotion regulation problems with right dmPFC activation. Bayesian analyses showed credible evidence for higher activation in all ROIs in the PTSD + BPD + CPD group compared to PTSD + BPD and PTSD + CPD.DISCUSSION: Our Bayesian and correlation analyses support new dimensional conceptualizations of personality disorders.
KW - Avoidant personality disorder
KW - Borderline Personality Disorder
KW - Cluster c personality disorder
KW - Emotional face task
KW - PSTD
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=85180777110&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.nicl.2023.103554
DO - https://doi.org/10.1016/j.nicl.2023.103554
M3 - Article
C2 - 38128160
SN - 2213-1582
VL - 41
SP - 103554
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 103554
ER -