TY - JOUR
T1 - Receptive Field Sizes of Nyxnob Mouse Retinal Ganglion Cells
AU - Hölzel, Maj-Britt
AU - Howlett, Marcus H. C.
AU - Kamermans, Maarten
N1 - Funding Information: Funding: This research was supported by a grant of the van Hessen-Israëls Fund of the Friends Foundation of the Netherlands Institute of Neuroscience, EU-Horizon 2020: Switchboard, Uitzicht: UT2016-13 and UT 20120-14. A generous donor funded this project via the Friends Foundation of the Netherlands Institute of Neuroscience Foundation. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Patients with congenital nystagmus, involuntary eye movements, often have a reduced visual acuity. Some of these patients have a retinal-specific mutation in the protein nyctalopin, which is also present in the Nyxnob mouse. In these mice, retinal ganglion cells (RGCs) have oscillatory activity, which leads to expanded axonal projections towards the dLGN and consequently to a desegregation of retinal projections to the brain. In this study, we investigate whether the receptive fields of Nyxnob RGCs have also expanded by measuring the size of their receptive fields using MEA recordings. Contrary to our expectation, relative to wild-type (WT) mice we found receptive field sizes in the Nyxnob retina had not increased but instead had decreased for green-light preferring RGCs. Additionally, we also found the receptive fields of UV-light preferring RGCs are larger than green-light preferring RGCs in both WT and Nyxnob mice.
AB - Patients with congenital nystagmus, involuntary eye movements, often have a reduced visual acuity. Some of these patients have a retinal-specific mutation in the protein nyctalopin, which is also present in the Nyxnob mouse. In these mice, retinal ganglion cells (RGCs) have oscillatory activity, which leads to expanded axonal projections towards the dLGN and consequently to a desegregation of retinal projections to the brain. In this study, we investigate whether the receptive fields of Nyxnob RGCs have also expanded by measuring the size of their receptive fields using MEA recordings. Contrary to our expectation, relative to wild-type (WT) mice we found receptive field sizes in the Nyxnob retina had not increased but instead had decreased for green-light preferring RGCs. Additionally, we also found the receptive fields of UV-light preferring RGCs are larger than green-light preferring RGCs in both WT and Nyxnob mice.
KW - CSNB
KW - Congenital nystagmus
KW - Green-light preferring RGCs
KW - Nyx
KW - Receptive field
KW - Retina
KW - Retinal ganglion cells (RGCs)
KW - UV-light preferring RGCs
UR - http://www.scopus.com/inward/record.url?scp=85126849962&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/ijms23063202
DO - https://doi.org/10.3390/ijms23063202
M3 - Article
C2 - 35328623
SN - 1661-6596
VL - 23
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 6
M1 - 3202
ER -