Abstract
Original language | English |
---|---|
Pages (from-to) | 1464-1480.e6 |
Number of pages | 17 |
Journal | CELL Host & Microbe |
Volume | 30 |
Issue number | 10 |
DOIs | |
Publication status | Published - 12 Oct 2022 |
Keywords
- HELIUS cohort
- Mendelian randomization
- cardiometabolic health
- causality
- ethnicity
- genome wide association study
- genotype
- immune system
- metabolism
- microbiome
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
In: CELL Host & Microbe, Vol. 30, No. 10, 12.10.2022, p. 1464-1480.e6.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Gut microbiome associations with host genotype vary across ethnicities and potentially influence cardiometabolic traits
AU - Boulund, Ulrika
AU - Bastos, Diogo M.
AU - Ferwerda, Bart
AU - van den Born, Bert-Jan
AU - Pinto-Sietsma, Sara-Joan
AU - Galenkamp, Henrike
AU - Levin, Evgeni
AU - Groen, Albert K.
AU - Zwinderman, Aeilko H.
AU - Nieuwdorp, Max
N1 - Funding Information: The HELIUS study is conducted by the Academic University Medical Centers, located in AMC, and the Public Health Service of Amsterdam. Both organizations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation , the Netherlands Organisation for Health Research and Development (ZonMw), the European Union (FP-7), and the European Fund for the Integration of non-EU immigrants ( EIF ). We gratefully acknowledge the AMC Biobank for their support in biobank management and high-quality storage of collected samples; and we thank the participants of the HELIUS study and its management team, research nurses, interviewers, research assistants, and other staff who have taken part in gathering the data of this study. We would also like to acknowledge input by Willem de Vos and Mary Nicolau on shaping the manuscript. Figures 6 and 7 and the graphical abstract contain illustrations that are adapted from Servier Medical Art ( https://smart.servier.com/ ) under a Creative Commons Attribution 3.0 Unported License. The graphical abstract was also created with adapted illustrations from the National Human Genome Research Institute ( genome.gov ). The study reported here was additionally supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 813781 (on which U.B. is appointed). The funders had no role in the study design; the collection, analysis, and interpretation of data; the writing of the report; or the decision to submit the article for publication. M.N. is funded by a ZonMw VICI grant 2020 ( 09150182010020 ). Funding Information: The HELIUS study is conducted by the Academic University Medical Centers, located in AMC, and the Public Health Service of Amsterdam. Both organizations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation, the Netherlands Organisation for Health Research and Development (ZonMw), the European Union (FP-7), and the European Fund for the Integration of non-EU immigrants (EIF). We gratefully acknowledge the AMC Biobank for their support in biobank management and high-quality storage of collected samples; and we thank the participants of the HELIUS study and its management team, research nurses, interviewers, research assistants, and other staff who have taken part in gathering the data of this study. We would also like to acknowledge input by Willem de Vos and Mary Nicolau on shaping the manuscript. Figures 6 and 7 and the graphical abstract contain illustrations that are adapted from Servier Medical Art (https://smart.servier.com/) under a Creative Commons Attribution 3.0 Unported License. The graphical abstract was also created with adapted illustrations from the National Human Genome Research Institute (genome.gov). The study reported here was additionally supported by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 813781 (on which U.B. is appointed). The funders had no role in the study design; the collection, analysis, and interpretation of data; the writing of the report; or the decision to submit the article for publication. M.N. is funded by a ZonMw VICI grant 2020 (09150182010020). Conceptualization, supervision, project administration, M.N. Methodology, software, formal analysis, visualization, writing—original draft, U.B. Resources, B.-J.v.d.B. S.-J.P.-S. and H.G. Data curation, U.B. B.F. and H.G. Writing—review and editing, U.B. D.M.B. B.F. B.-J.v.d.B. S.J.P.-S. H.G. E.L. A.K.G. A.H.Z. and M.N. Funding acquisition, B.-J.v.d.B. K.Z. and M.N. M.N. is on the Scientific Advisory Board of Caelus Pharmaceuticals, the Netherlands. This is not directly relevant to the current paper. There are no patents, products in development, or marketed products to declare. Publisher Copyright: © 2022 Elsevier Inc.
PY - 2022/10/12
Y1 - 2022/10/12
N2 - Previous studies in mainly European populations have reported that the gut microbiome composition is associated with the human genome. However, the genotype-microbiome interaction in different ethnicities is largely unknown. We performed a large fecal microbiome genome-wide association study of a single multiethnic cohort, the Healthy Life in an Urban Setting (HELIUS) cohort (N = 4,117). Mendelian randomization was performed using the multiethnic Pan-UK Biobank (N = 460,000) to dissect potential causality. We identified ethnicity-specific associations between host genomes and gut microbiota. Certain microbes were associated with genotype in multiple ethnicities. Several of the microbe-associated loci were found to be related to immune functions, interact with glutamate and the mucus layer, or be expressed in the gut or brain. Additionally, we found that gut microbes potentially influence cardiometabolic health factors such as BMI, cholesterol, and blood pressure. This provides insight into the relationship of ethnicity and gut microbiota and into the possible causal effects of gut microbes on cardiometabolic traits.
AB - Previous studies in mainly European populations have reported that the gut microbiome composition is associated with the human genome. However, the genotype-microbiome interaction in different ethnicities is largely unknown. We performed a large fecal microbiome genome-wide association study of a single multiethnic cohort, the Healthy Life in an Urban Setting (HELIUS) cohort (N = 4,117). Mendelian randomization was performed using the multiethnic Pan-UK Biobank (N = 460,000) to dissect potential causality. We identified ethnicity-specific associations between host genomes and gut microbiota. Certain microbes were associated with genotype in multiple ethnicities. Several of the microbe-associated loci were found to be related to immune functions, interact with glutamate and the mucus layer, or be expressed in the gut or brain. Additionally, we found that gut microbes potentially influence cardiometabolic health factors such as BMI, cholesterol, and blood pressure. This provides insight into the relationship of ethnicity and gut microbiota and into the possible causal effects of gut microbes on cardiometabolic traits.
KW - HELIUS cohort
KW - Mendelian randomization
KW - cardiometabolic health
KW - causality
KW - ethnicity
KW - genome wide association study
KW - genotype
KW - immune system
KW - metabolism
KW - microbiome
UR - http://www.scopus.com/inward/record.url?scp=85139743039&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85139743039&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36099924
U2 - https://doi.org/10.1016/j.chom.2022.08.013
DO - https://doi.org/10.1016/j.chom.2022.08.013
M3 - Article
C2 - 36099924
SN - 1931-3128
VL - 30
SP - 1464-1480.e6
JO - CELL Host & Microbe
JF - CELL Host & Microbe
IS - 10
ER -