Varicella zoster-associated acute retinal necrosis and central nervous system complications in natalizumab treated MS patients

Zoé L. E. van Kempen; Johannis A. van Rossum; Erwin Hoogervorst; Eva Strijbis; Alyssa Toorop; Machteld I. Bosscha; Stephan Frequin; Ninette ten Dam-van Loon; Mike P. Wattjes; Jean-Luc Murk; Joep Killestein; Bernard M. J. Uitdehaag

doi:https://doi.org/10.1016/j.msard.2021.102838

Varicella zoster-associated acute retinal necrosis and central nervous system complications in natalizumab treated MS patients

Zoé L. E. van Kempen, Johannis A. van Rossum, Erwin Hoogervorst, Eva Strijbis, Alyssa Toorop, Machteld I. Bosscha, Stephan Frequin, Ninette ten Dam-van Loon, Mike P. Wattjes, Jean-Luc Murk, Joep Killestein, Bernard M. J. Uitdehaag

Research output: Contribution to journal › Comment/Letter to the editor › Academic

7 Citations (Scopus)

Abstract

There is not much awareness of varicella zoster virus (VZV) associated central nervous system (CNS) infections under treatment with natalizumab. Here we describe two natalizumab treated MS patients who developed acute retinal necrosis combined with CNS vasculitis caused by VZV. In natalizumab treated patients, visual symptoms atypical of optic neuritis should be promptly evaluated by an ophthalmologist. Currently, a total of 12 cases of natalizumab-associated VZV CNS or retinal infections are reported in literature. Our two cases and overview of currently available data provide information on prognosis and treatment decisions of this rare but devastating complication.

Original language	English
Article number	102838
Journal	Multiple Sclerosis and Related Disorders
Volume	50
DOIs	https://doi.org/10.1016/j.msard.2021.102838
Publication status	Published - 1 May 2021

Keywords

Multiple sclerosis
Natalizumab
Retinal necrosis
Varicella zoster
Vasculitis

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van Kempen, Z. L. E., van Rossum, J. A., Hoogervorst, E., Strijbis, E., Toorop, A., Bosscha, M. I., Frequin, S., Dam-van Loon, N. T., Wattjes, M. P., Murk, J.-L., Killestein, J., & Uitdehaag, B. M. J. (2021). Varicella zoster-associated acute retinal necrosis and central nervous system complications in natalizumab treated MS patients. Multiple Sclerosis and Related Disorders, 50, Article 102838. https://doi.org/10.1016/j.msard.2021.102838

@article{07f3acb02cae43949056bc83766cb7d0,

title = "Varicella zoster-associated acute retinal necrosis and central nervous system complications in natalizumab treated MS patients",

abstract = "There is not much awareness of varicella zoster virus (VZV) associated central nervous system (CNS) infections under treatment with natalizumab. Here we describe two natalizumab treated MS patients who developed acute retinal necrosis combined with CNS vasculitis caused by VZV. In natalizumab treated patients, visual symptoms atypical of optic neuritis should be promptly evaluated by an ophthalmologist. Currently, a total of 12 cases of natalizumab-associated VZV CNS or retinal infections are reported in literature. Our two cases and overview of currently available data provide information on prognosis and treatment decisions of this rare but devastating complication.",

keywords = "Multiple sclerosis, Natalizumab, Retinal necrosis, Varicella zoster, Vasculitis",

author = "{van Kempen}, {Zo{\'e} L. E.} and {van Rossum}, {Johannis A.} and Erwin Hoogervorst and Eva Strijbis and Alyssa Toorop and Bosscha, {Machteld I.} and Stephan Frequin and {Dam-van Loon}, {Ninette ten} and Wattjes, {Mike P.} and Jean-Luc Murk and Joep Killestein and Uitdehaag, {Bernard M. J.}",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = may,

day = "1",

doi = "https://doi.org/10.1016/j.msard.2021.102838",

language = "English",

volume = "50",

journal = "Multiple Sclerosis and Related Disorders",

issn = "2211-0348",

publisher = "Elsevier",

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van Kempen, ZLE , van Rossum, JA, Hoogervorst, E, Strijbis, E , Toorop, A , Bosscha, MI, Frequin, S, Dam-van Loon, NT, Wattjes, MP, Murk, J-L, Killestein, J & Uitdehaag, BMJ 2021, 'Varicella zoster-associated acute retinal necrosis and central nervous system complications in natalizumab treated MS patients', Multiple Sclerosis and Related Disorders, vol. 50, 102838. https://doi.org/10.1016/j.msard.2021.102838

TY - JOUR

T1 - Varicella zoster-associated acute retinal necrosis and central nervous system complications in natalizumab treated MS patients

AU - van Kempen, Zoé L. E.

AU - van Rossum, Johannis A.

AU - Hoogervorst, Erwin

AU - Strijbis, Eva

AU - Toorop, Alyssa

AU - Bosscha, Machteld I.

AU - Frequin, Stephan

AU - Dam-van Loon, Ninette ten

AU - Wattjes, Mike P.

AU - Murk, Jean-Luc

AU - Killestein, Joep

AU - Uitdehaag, Bernard M. J.

PY - 2021/5/1

Y1 - 2021/5/1

N2 - There is not much awareness of varicella zoster virus (VZV) associated central nervous system (CNS) infections under treatment with natalizumab. Here we describe two natalizumab treated MS patients who developed acute retinal necrosis combined with CNS vasculitis caused by VZV. In natalizumab treated patients, visual symptoms atypical of optic neuritis should be promptly evaluated by an ophthalmologist. Currently, a total of 12 cases of natalizumab-associated VZV CNS or retinal infections are reported in literature. Our two cases and overview of currently available data provide information on prognosis and treatment decisions of this rare but devastating complication.

AB - There is not much awareness of varicella zoster virus (VZV) associated central nervous system (CNS) infections under treatment with natalizumab. Here we describe two natalizumab treated MS patients who developed acute retinal necrosis combined with CNS vasculitis caused by VZV. In natalizumab treated patients, visual symptoms atypical of optic neuritis should be promptly evaluated by an ophthalmologist. Currently, a total of 12 cases of natalizumab-associated VZV CNS or retinal infections are reported in literature. Our two cases and overview of currently available data provide information on prognosis and treatment decisions of this rare but devastating complication.

KW - Multiple sclerosis

KW - Natalizumab

KW - Retinal necrosis

KW - Varicella zoster

KW - Vasculitis

UR - http://www.scopus.com/inward/record.url?scp=85101394314&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.msard.2021.102838

DO - https://doi.org/10.1016/j.msard.2021.102838

M3 - Comment/Letter to the editor

C2 - 33609925

SN - 2211-0348

VL - 50

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

M1 - 102838

ER -

Varicella zoster-associated acute retinal necrosis and central nervous system complications in natalizumab treated MS patients

Abstract

Keywords

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