TY - JOUR
T1 - Automated analysis of finger blood pressure recordings provides insight in determinants of baroreflex sensitivity and heart rate variability?the HELIUS study
AU - Collard, D.
AU - Westerhof, B. E.
AU - Karemaker, J. M.
AU - Stok, W. J.
AU - Postema, P. G.
AU - Krediet, C. T. P.
AU - Vogt, L.
AU - van den Born, B. J. H.
N1 - Funding Information: The HELIUS study is conducted by the Amsterdam UMC, location AMC, and the Public Health Service (GGD) of Amsterdam. Both organizations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation, the Netherlands Organization for Health Research and Development (ZonMw), the European Union (FP-7), and the European Fund for the Integration of non-EU immigrants (EIF). Publisher Copyright: © 2023, The Author(s).
PY - 2023/5
Y1 - 2023/5
N2 - Sympathovagal balance is important in the pathogenesis of hypertension and independently associated with mortality. We evaluated the value of automated analysis of cross-correlation baroreflex sensitivity (xBRS) and heart rate variability (HRV) and its relationship with clinical covariates in 13,326 participants from the multi-ethnic HELIUS study. Finger blood pressure (BP) was continuously recorded, from which xBRS, standard deviation of normal-to-normal intervals (SDNN), and squared root of mean squared successive difference between normal-to-normal intervals (RMSDD) were determined. A subset of?3356 recordings > 300?s was used to derive the minimally required duration by comparing shortened to complete recordings, defined as intraclass correlation (ICC) > 0.90. For xBRS and SDNN, 120?s and 180?s were required (ICC 0.93); for RMSDD, 60?s (ICC 0.94) was sufficient. We included 10,252 participants (median age 46?years, 54% women) with a recording > 180?s for the regression. xBRS, SDNN, and RMSDD decreased linearly up to 50?years?of age. For xBRS, there was a signification interaction with sex, with for every 10?years a decrease of 4.3?ms/mmHg (95%CI 4.0?4.6) for men and 5.9?ms/mmHg (95%CI 5.6?6.1) for women. Using splines, we observed sex-dependent nonlinearities in the relation with BP, waist-to-hip-ratio, and body mass index. Future studies can help unravel the dynamics of these relations and assess their predictive value. Graphical Abstract: Panel 1 depicts automatic analysis and filtering of finger BP recordings, panel 2 depicts computation of xBRS from interpolated beat to beat data of systolic BP and interbeat interval, and (IBI) SDNN and RMSDD are computed directly from the filtered IBI dataset. Panel 3 depicts the results of large-scale analysis and relation of xBRS with age, sex, blood pressure and body mass index. [Figure not available: see fulltext.].
AB - Sympathovagal balance is important in the pathogenesis of hypertension and independently associated with mortality. We evaluated the value of automated analysis of cross-correlation baroreflex sensitivity (xBRS) and heart rate variability (HRV) and its relationship with clinical covariates in 13,326 participants from the multi-ethnic HELIUS study. Finger blood pressure (BP) was continuously recorded, from which xBRS, standard deviation of normal-to-normal intervals (SDNN), and squared root of mean squared successive difference between normal-to-normal intervals (RMSDD) were determined. A subset of?3356 recordings > 300?s was used to derive the minimally required duration by comparing shortened to complete recordings, defined as intraclass correlation (ICC) > 0.90. For xBRS and SDNN, 120?s and 180?s were required (ICC 0.93); for RMSDD, 60?s (ICC 0.94) was sufficient. We included 10,252 participants (median age 46?years, 54% women) with a recording > 180?s for the regression. xBRS, SDNN, and RMSDD decreased linearly up to 50?years?of age. For xBRS, there was a signification interaction with sex, with for every 10?years a decrease of 4.3?ms/mmHg (95%CI 4.0?4.6) for men and 5.9?ms/mmHg (95%CI 5.6?6.1) for women. Using splines, we observed sex-dependent nonlinearities in the relation with BP, waist-to-hip-ratio, and body mass index. Future studies can help unravel the dynamics of these relations and assess their predictive value. Graphical Abstract: Panel 1 depicts automatic analysis and filtering of finger BP recordings, panel 2 depicts computation of xBRS from interpolated beat to beat data of systolic BP and interbeat interval, and (IBI) SDNN and RMSDD are computed directly from the filtered IBI dataset. Panel 3 depicts the results of large-scale analysis and relation of xBRS with age, sex, blood pressure and body mass index. [Figure not available: see fulltext.].
KW - Algorithms
KW - BRS
KW - Cohort study
KW - HRV
KW - Sympathovagal balance
UR - http://www.scopus.com/inward/record.url?scp=85146647749&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s11517-023-02768-4
DO - https://doi.org/10.1007/s11517-023-02768-4
M3 - Article
C2 - 36683125
SN - 0140-0118
VL - 61
SP - 1183
EP - 1191
JO - Medical and Biological Engineering and Computing
JF - Medical and Biological Engineering and Computing
IS - 5
ER -