TY - JOUR
T1 - The Cortisol Awakening Response as a Biomarker for Cognitive Side-Effects of Electroconvulsive Therapy
AU - Feenstra, Thomas C.
AU - la Cruz, Eldon K. J.
AU - Obbels, Jasmien
AU - Laroy, Maarten
AU - Bouckaert, Filip
AU - Sienaert, Pascal
AU - Oudega, Mardien
AU - Dols, Annemieke
AU - van Exel, Eric
AU - Beekman, Aartjan T. F.
AU - Rhebergen, Didi
N1 - Publisher Copyright: © 2023 American Association for Geriatric Psychiatry
PY - 2023/11
Y1 - 2023/11
N2 - Objective: To test whether the cortisol awakening response (CAR) could be a biomarker for cognitive decline during electroconvulsive therapy (ECT). Methods: We studied 50 older patients with depression who were treated with ECT from the MODECT cohort. We used linear regression analyses to examine the association between CAR and cognitive change, assessed by the change in Mini Mental State Examination scores between baseline and 1 week after ECT course. CAR was assessed by the area under the curve of cortisol levels, according to Pruessner's-formula. Associations were adjusted for putative confounders, based on previous literature and availability. Results: We found no significant associations between the CAR and cognitive change during the ECT course in (un)adjusted models. Conclusion: Our results indicate that the CAR is not usable as a biomarker for ECT-induced cognitive decline during ECT course. Further research in cohorts with larger samples is needed.
AB - Objective: To test whether the cortisol awakening response (CAR) could be a biomarker for cognitive decline during electroconvulsive therapy (ECT). Methods: We studied 50 older patients with depression who were treated with ECT from the MODECT cohort. We used linear regression analyses to examine the association between CAR and cognitive change, assessed by the change in Mini Mental State Examination scores between baseline and 1 week after ECT course. CAR was assessed by the area under the curve of cortisol levels, according to Pruessner's-formula. Associations were adjusted for putative confounders, based on previous literature and availability. Results: We found no significant associations between the CAR and cognitive change during the ECT course in (un)adjusted models. Conclusion: Our results indicate that the CAR is not usable as a biomarker for ECT-induced cognitive decline during ECT course. Further research in cohorts with larger samples is needed.
KW - Major depressive disorder
KW - cognitive side-effects
KW - cortisol
KW - electroconvulsive therapy
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85165263689&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/37479670
UR - http://www.scopus.com/inward/record.url?scp=85165263689&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jagp.2023.07.004
DO - https://doi.org/10.1016/j.jagp.2023.07.004
M3 - Article
C2 - 37479670
SN - 1064-7481
VL - 31
SP - 991
EP - 995
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 11
ER -