TY - JOUR
T1 - Results of the Eighth Scientific Workshop of ECCO
T2 - Pathophysiology and Risk Factors of Postoperative Crohn's Disease Recurrence after an Ileocolonic Resection
AU - Rivière, Pauline
AU - Bislenghi, Gabriele
AU - Hammoudi, Nassim
AU - Verstockt, Bram
AU - Brown, Steven
AU - Oliveira-Cunha, Melissa
AU - Bemelman, Willem
AU - Pellino, Gianluca
AU - Kotze, Paulo Gustavo
AU - Ferrante, Marc
AU - 8th Scientific Workshop of the European Crohn’s and Colitis Organisation
AU - Panis, Yves
N1 - Publisher Copyright: © 2023 Oxford University Press. All rights reserved.
PY - 2023/10/1
Y1 - 2023/10/1
N2 - Postoperative recurrence [POR] after an ileocolonic resection with ileocolonic anastomosis is frequently encountered in patients with Crohn's disease. The 8th Scientific Workshop of ECCO reviewed the available evidence on the pathophysiology and risk factors for POR. In this paper, we discuss published data on the role of the microbiome, the mesentery, the immune system and the genetic background. In addition to investigating the causative mechanisms of POR, identification of risk factors is essential to tailor preventive strategies. Potential clinical, surgical and histological risk factors are presented along with their limitations. Emphasis is placed on unanswered research questions, guiding prevention of POR based on individual patient profiles.
AB - Postoperative recurrence [POR] after an ileocolonic resection with ileocolonic anastomosis is frequently encountered in patients with Crohn's disease. The 8th Scientific Workshop of ECCO reviewed the available evidence on the pathophysiology and risk factors for POR. In this paper, we discuss published data on the role of the microbiome, the mesentery, the immune system and the genetic background. In addition to investigating the causative mechanisms of POR, identification of risk factors is essential to tailor preventive strategies. Potential clinical, surgical and histological risk factors are presented along with their limitations. Emphasis is placed on unanswered research questions, guiding prevention of POR based on individual patient profiles.
KW - Crohn's disease
KW - mesentery
KW - microbiome
KW - postoperative recurrence
KW - surgery
UR - http://www.scopus.com/inward/record.url?scp=85176508554&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/ecco-jcc/jjad054
DO - https://doi.org/10.1093/ecco-jcc/jjad054
M3 - Article
C2 - 37070326
SN - 1873-9946
VL - 17
SP - 1557
EP - 1568
JO - Journal of Crohn's & Colitis
JF - Journal of Crohn's & Colitis
IS - 10
ER -