2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches

John M. Mahoney, James D. Mills, Angelika Muhlebner, Jeffrey Noebels, Heidrun Potschka, Michele Simonato, Katja Kobow

Research output: Contribution to journalReview articleAcademicpeer-review

13 Citations (Scopus)

Abstract

The revolution in high-throughput omics technologies has dramatically expanded our understanding of the epilepsies as complex diseases. It is now clear that further progress in treating the full spectrum of seizure disorders requires a systems-level framework for analyzing and integrating data from multiple omics technologies that moves beyond the search for single molecular alterations to an understanding of dysregulated pathways in epilepsy. Taking such a pathway-centered view requires further integrating the tools of systems biology into epilepsy research. In this appraisal, we highlight and summarize systems biology approaches in basic epilepsy studies as they were discussed during the 2017 Workshop on the Neurobiology of Epilepsy (WONOEP). During the 3-day event, participants exchanged emerging results and thoughts on developing the systems biology of epilepsy, and the promise and limitations of these approaches for the near term.
Original languageEnglish
Pages (from-to)1045-1053
Number of pages9
JournalEpilepsia
Volume60
Issue number6
Early online date14 May 2019
DOIs
Publication statusPublished - Jun 2019

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