25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study

Ilse I. M. Tromp, Oscar H. Franco, Edith H. van den Hooven, Annemieke C. Heijboer, Vincent W. V. Jaddoe, Liesbeth Duijts, Johan C. de Jongste, Henriëtte A. Moll, Jessica C. Kiefte-de Jong

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8 Citations (Scopus)


Background & aims: A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter resistance (Rint), physician diagnosed asthma ever, wheezing and eczema in a population-based cohort study in 6 year old children. Methods: Serum 25(OH) vitamin D concentration was assessed in 3815 children. 25(OH) vitamin D concentrations ≥75 nmol/L were considered as sufficient, between 50 and 75 nmol/L as insufficient, and <50 nmol/L as deficient. FeNO and Rint were measured at the research center. Data on physician diagnosed asthma, wheezing, and eczema were obtained by parent-reported questionnaires. Results: In comparison with sufficient 25(OH) vitamin D concentration, deficient concentrations were associated with elevated FeNO of ≥25 ppb (OR: 2.54; 95% CI: 1.34–4.80). In addition, deficient and insufficient 25(OH) vitamin D concentrations were associated with a lower Rint (Z-score: −1.26; 95% CI: −1.66 to −0.85) (ß: −0.75; 95% CI: −1.08 to −0.42), and increased risks of eczema (OR: 1.65; 95% CI: 1.13–2.41) (OR: 1.44; 95% CI: 1.06–1.95). Insufficient 25(OH) vitamin D concentration were associated with a decreased risk of physician diagnosed asthma ever (OR: 0.59; 95% CI: 0.38–0.94). Conclusions: Our results indicate that lower 25(OH) vitamin D levels are associated with elevated FeNO levels, but lower Rint values. Lower 25(OH) vitamin D levels are also associated with a decreased risk for asthma diagnoses but an increased risk for eczema.
Original languageEnglish
Pages (from-to)169-176
JournalClinical Nutrition
Issue number1
Early online date2016
Publication statusPublished - 2018

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