Acute kidney injury associated with nephrotoxic drugs in critically ill patients: a multicenter cohort study using electronic health record data.

Izak A.R. Yasrebi-de Kom; D Dongelmans; Ameen Abu-Hanna; Martinus Schut; Dylan W. de Lange; Eric van Roon; E. de Jonge; C.S.C. Bouman; N.F. de Keizer; Kitty Jager; J.E. Klopotowska

doi:https://doi.org/10.1093/ckj/sfad160

Acute kidney injury associated with nephrotoxic drugs in critically ill patients: a multicenter cohort study using electronic health record data.

Izak A.R. Yasrebi-de Kom, D Dongelmans, Ameen Abu-Hanna, Martinus Schut, Dylan W. de Lange, Eric van Roon, E. de Jonge, C.S.C. Bouman, N.F. de Keizer, Kitty Jager, J.E. Klopotowska

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Acute kidney injury (AKI) is a common problem in adult intensive care unit (ICU) patients and is often caused by nephrotoxic drugs. However, due to a lack of large pharmaco-epidemiological studies investigating the associations between drugs and AKI, our knowledge on the nephrotoxicity of drugs is limited. This hampers our ability to improve medication safety in the ICU. Using real-world data from 13 ICUs on 92,616 ICU admissions, we estimated the associations between 44 (potentially) nephrotoxic drug groups and AKI whilst adjusting for confounding. In total, 14 groups were associated with a higher hazard of AKI. Our approach confirms existing knowledge and provides new insights and directions for current ICU practice and follow-up research regarding AKI associated with drugs.

Original language	English
Journal	Clinical Kidney Journal
DOIs	https://doi.org/10.1093/ckj/sfad160
Publication status	E-pub ahead of print - 5 Jul 2023

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https://doi.org/10.1093/ckj/sfad160Licence: CC BY

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Yasrebi-de Kom, I. A. R., Dongelmans, D., Abu-Hanna, A., Schut, M., de Lange, D. W., van Roon, E., de Jonge, E., Bouman, C. S. C., de Keizer, N. F., Jager, K., & Klopotowska, J. E. (2023). Acute kidney injury associated with nephrotoxic drugs in critically ill patients: a multicenter cohort study using electronic health record data. Clinical Kidney Journal. Advance online publication. https://doi.org/10.1093/ckj/sfad160

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title = "Acute kidney injury associated with nephrotoxic drugs in critically ill patients: a multicenter cohort study using electronic health record data.",

abstract = "Acute kidney injury (AKI) is a common problem in adult intensive care unit (ICU) patients and is often caused by nephrotoxic drugs. However, due to a lack of large pharmaco-epidemiological studies investigating the associations between drugs and AKI, our knowledge on the nephrotoxicity of drugs is limited. This hampers our ability to improve medication safety in the ICU. Using real-world data from 13 ICUs on 92,616 ICU admissions, we estimated the associations between 44 (potentially) nephrotoxic drug groups and AKI whilst adjusting for confounding. In total, 14 groups were associated with a higher hazard of AKI. Our approach confirms existing knowledge and provides new insights and directions for current ICU practice and follow-up research regarding AKI associated with drugs.",

author = "{Yasrebi-de Kom}, {Izak A.R.} and D Dongelmans and Ameen Abu-Hanna and Martinus Schut and {de Lange}, {Dylan W.} and {van Roon}, Eric and {de Jonge}, E. and C.S.C. Bouman and {de Keizer}, N.F. and Kitty Jager and J.E. Klopotowska",

year = "2023",

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day = "5",

doi = "https://doi.org/10.1093/ckj/sfad160",

language = "English",

journal = "Clinical Kidney Journal",

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Yasrebi-de Kom, IAR , Dongelmans, D , Abu-Hanna, A , Schut, M, de Lange, DW, van Roon, E, de Jonge, E, Bouman, CSC , de Keizer, NF , Jager, K & Klopotowska, JE 2023, 'Acute kidney injury associated with nephrotoxic drugs in critically ill patients: a multicenter cohort study using electronic health record data.', Clinical Kidney Journal. https://doi.org/10.1093/ckj/sfad160

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T1 - Acute kidney injury associated with nephrotoxic drugs in critically ill patients: a multicenter cohort study using electronic health record data.

AU - Yasrebi-de Kom, Izak A.R.

AU - Dongelmans, D

AU - Abu-Hanna, Ameen

AU - Schut, Martinus

AU - de Lange, Dylan W.

AU - van Roon, Eric

AU - de Jonge, E.

AU - Bouman, C.S.C.

AU - de Keizer, N.F.

AU - Jager, Kitty

AU - Klopotowska, J.E.

PY - 2023/7/5

Y1 - 2023/7/5

N2 - Acute kidney injury (AKI) is a common problem in adult intensive care unit (ICU) patients and is often caused by nephrotoxic drugs. However, due to a lack of large pharmaco-epidemiological studies investigating the associations between drugs and AKI, our knowledge on the nephrotoxicity of drugs is limited. This hampers our ability to improve medication safety in the ICU. Using real-world data from 13 ICUs on 92,616 ICU admissions, we estimated the associations between 44 (potentially) nephrotoxic drug groups and AKI whilst adjusting for confounding. In total, 14 groups were associated with a higher hazard of AKI. Our approach confirms existing knowledge and provides new insights and directions for current ICU practice and follow-up research regarding AKI associated with drugs.

AB - Acute kidney injury (AKI) is a common problem in adult intensive care unit (ICU) patients and is often caused by nephrotoxic drugs. However, due to a lack of large pharmaco-epidemiological studies investigating the associations between drugs and AKI, our knowledge on the nephrotoxicity of drugs is limited. This hampers our ability to improve medication safety in the ICU. Using real-world data from 13 ICUs on 92,616 ICU admissions, we estimated the associations between 44 (potentially) nephrotoxic drug groups and AKI whilst adjusting for confounding. In total, 14 groups were associated with a higher hazard of AKI. Our approach confirms existing knowledge and provides new insights and directions for current ICU practice and follow-up research regarding AKI associated with drugs.

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DO - https://doi.org/10.1093/ckj/sfad160

M3 - Article

SN - 2048-8513

JO - Clinical Kidney Journal

JF - Clinical Kidney Journal

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