@article{3023fdb3bad34f9395e1422f07a8cea1,
title = "Impact of high human genetic diversity in Africa on immunogenicity and efficacy of RTS,S/AS01 vaccine",
abstract = "In modern medicine, vaccination is one of the most effective public health strategies to prevent infectious diseases. Indisputably, vaccines have saved millions of lives by reducing the burden of many serious infections such as polio, tuberculosis, measles, pneumonia, and tetanus. Despite the recent recommendation by the World Health Organization (WHO) to roll out RTS,S/AS01, this malaria vaccine still faces major challenges of variability in its efficacy partly due to high genetic variation in humans and malaria parasites. Immune responses to malaria vary between individuals and populations. Human genetic variation in immune system genes is the probable cause for this heterogeneity. In this review, we will focus on human genetic factors that determine variable responses to vaccination and how variation in immune system genes affect the immunogenicity and efficacy of the RTS,S/AS01 vaccine.",
keywords = "Africa, Genetic variation, Malaria, RTS,S/AS01 vaccine",
author = "Stephen Tukwasibwe and Gerald Mboowa and Ivan Sserwadda and Nankabirwa, {Joaniter I.} and Emmanuel Arinaitwe and Isaac Ssewanyana and Yoweri Taremwa and Gerald Tumusiime and Kamya, {Moses R.} and Prasanna Jagannathan and Annettee Nakimuli",
note = "Funding Information: Support for this work was partly provided by Fogarty International Center, National Institutes of Health (grant no. 2D43TW009771-06 “HIV and Co-infections in Uganda”) that funded Stephen Tukwasibwe and Gerald Mboowa through Postdoctoral fellowship awards. This work was also partly supported by the Thrasher Research Fund for Stephen Tukwasibwe. Gerald Mboowa is part of the EDCTP2 program supported by the European Union (grant no. TMA2020CDF-3159-PHICAMS). Ivan Sserwadda is a PhD fellow funded by the EDCTP Scholarship program through the CAGE TB Project. Part of his work is also funded by the Public Health Alliance for Genomic Epidemiology (PHA4GE) grant number (INV-038071) supporting pathogen genomics data standards and bioinformatics interoperability. The views expressed in this publication are those of the authors and not necessarily those of the funders. Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",
year = "2023",
month = jun,
doi = "https://doi.org/10.1007/s00251-023-01306-8",
language = "English",
volume = "75",
pages = "207--214",
journal = "Immunogenetics",
issn = "0093-7711",
publisher = "Springer Verlag",
number = "3",
}