TY - JOUR
T1 - Retinoic acid signaling in heart development
T2 - Application in the differentiation of cardiovascular lineages from human pluripotent stem cells
AU - Wiesinger, Alexandra
AU - Boink, Gerard J. J.
AU - Christoffels, Vincent M.
AU - Devalla, Harsha D.
N1 - Funding Information: This work is supported by funding from European Research Council starting grant 714866 and associated proof-of-concept grant 899422, Health Holland LentiPace II to G.J.J.B.; Netherlands Organization for Health Research and Development (ZonMW) , ZonMW TOP 40-00812-98-17061 to V.M.C., ZonMW and the Dutch Heart Foundation MKMD grant 114021512, and Dutch Heart Foundation Dekker fellowship 2020T023 to H.D.D. Publisher Copyright: © 2021 The Authors
PY - 2021/11/9
Y1 - 2021/11/9
N2 - Retinoic acid (RA) signaling plays an important role during heart development in establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and growth of the ventricular compact wall. RA is also utilized as a key ingredient in protocols designed for generating cardiac cell types from pluripotent stem cells (PSCs). This review discusses the role of RA in cardiogenesis, currently available protocols that employ RA for differentiation of various cardiovascular lineages, and plausible transcriptional mechanisms underlying this fate specification. These insights will inform further development of desired cardiac cell types from human PSCs and their application in preclinical and clinical research.
AB - Retinoic acid (RA) signaling plays an important role during heart development in establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and growth of the ventricular compact wall. RA is also utilized as a key ingredient in protocols designed for generating cardiac cell types from pluripotent stem cells (PSCs). This review discusses the role of RA in cardiogenesis, currently available protocols that employ RA for differentiation of various cardiovascular lineages, and plausible transcriptional mechanisms underlying this fate specification. These insights will inform further development of desired cardiac cell types from human PSCs and their application in preclinical and clinical research.
UR - http://www.scopus.com/inward/record.url?scp=85118504174&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.stemcr.2021.09.010
DO - https://doi.org/10.1016/j.stemcr.2021.09.010
M3 - Review article
C2 - 34653403
SN - 2213-6711
VL - 16
SP - 2589
EP - 2606
JO - Stem cell reports
JF - Stem cell reports
IS - 11
ER -