TY - JOUR
T1 - Influenza season influence on outcome of new nodules in the NELSON study
AU - Lancaster, H. L.
AU - Heuvelmans, M. A.
AU - de Bock, G. H.
AU - du, Y.
AU - Mohamed Hoesein, F. A. A.
AU - Nackaerts, K.
AU - Walter, J. E.
AU - Vliegenthart, R.
AU - Oudkerk, M.
N1 - Funding Information: R. Vliegenthart is supported by an institutional research grant from Siemens Healthineers. All other authors have no conflicts of interest to declare. Publisher Copyright: © 2023, The Author(s).
PY - 2023/12/1
Y1 - 2023/12/1
N2 - We evaluated the impact of the influenza season on outcome of new lung nodules in a LDCT lung cancer screening trial population. NELSON-trial participants with ≥ 1 new nodule detected in screening rounds two and three were included. Outcome (resolution or persistence) of new nodules detected per season was calculated and compared. Winter (influenza season) was defined as 1st October to 31st March, and compared to the summer (hay-fever season), 1st April to 30th September. Overall, 820 new nodules were reported in 529 participants. Of the total new nodules, 482 (59%) were reported during winter. When considering the outcome of all new nodules, there was no statistically significant association between summer and resolving nodules (OR 1.07 [CI 1.00–1.15], p = 0.066), also when looking at the largest nodule per participant (OR 1.37 [CI 0.95–1.98], p = 0.094). Similarly, there was no statistically significant association between season and screen detected cancers (OR 0.47 [CI 0.18–1.23], p = 0.123). To conclude, in this lung cancer screening population, there was no statistically significant association between influenza season and outcome of new lung nodules. Hence, we recommend new nodule management strategy is not influenced by the season in which the nodule is detected.
AB - We evaluated the impact of the influenza season on outcome of new lung nodules in a LDCT lung cancer screening trial population. NELSON-trial participants with ≥ 1 new nodule detected in screening rounds two and three were included. Outcome (resolution or persistence) of new nodules detected per season was calculated and compared. Winter (influenza season) was defined as 1st October to 31st March, and compared to the summer (hay-fever season), 1st April to 30th September. Overall, 820 new nodules were reported in 529 participants. Of the total new nodules, 482 (59%) were reported during winter. When considering the outcome of all new nodules, there was no statistically significant association between summer and resolving nodules (OR 1.07 [CI 1.00–1.15], p = 0.066), also when looking at the largest nodule per participant (OR 1.37 [CI 0.95–1.98], p = 0.094). Similarly, there was no statistically significant association between season and screen detected cancers (OR 0.47 [CI 0.18–1.23], p = 0.123). To conclude, in this lung cancer screening population, there was no statistically significant association between influenza season and outcome of new lung nodules. Hence, we recommend new nodule management strategy is not influenced by the season in which the nodule is detected.
UR - http://www.scopus.com/inward/record.url?scp=85153546570&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41598-023-33672-4
DO - https://doi.org/10.1038/s41598-023-33672-4
M3 - Article
C2 - 37085595
SN - 2045-2322
VL - 13
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 6589
ER -