TY - JOUR
T1 - Awakening after a sleeping pill
T2 - Restoring functional brain networks after severe brain injury
AU - Arnts, Hisse
AU - van Erp, Willemijn S.
AU - Boon, Lennard I.
AU - Bosman, Conrado A.
AU - Admiraal, Marjolein M.
AU - Schrantee, Anouk
AU - Pennartz, Cyriel M. A.
AU - Schuurman, Rick
AU - Stam, Cornelis J.
AU - van Rootselaar, Anne-Fleur
AU - Hillebrand, Arjan
AU - van den Munckhof, Pepijn
N1 - Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Some patients with severe brain injury show short-term neurological improvements, such as recovery of consciousness, motor function, or speech after administering zolpidem, a GABA receptor agonist. The working mechanism of this paradoxical phenomenon remains unknown. In this study, we used electroencephalography and magnetoencephalography to investigate a spectacular zolpidem-induced awakening, including the recovery of functional communication and the ability to walk in a patient with severe hypoxic-ischemic brain injury. We show that cognitive deficits, speech loss, and motor impairments after severe brain injury are associated with stronger beta band connectivity throughout the brain and suggest that neurological recovery after zolpidem occurs with the restoration of beta band connectivity. This exploratory work proposes an essential role for beta rhythms in goal-directed behavior and cognition. It advocates further fundamental and clinical research on the role of increased beta band connectivity in the development of neurological deficits after severe brain injury.
AB - Some patients with severe brain injury show short-term neurological improvements, such as recovery of consciousness, motor function, or speech after administering zolpidem, a GABA receptor agonist. The working mechanism of this paradoxical phenomenon remains unknown. In this study, we used electroencephalography and magnetoencephalography to investigate a spectacular zolpidem-induced awakening, including the recovery of functional communication and the ability to walk in a patient with severe hypoxic-ischemic brain injury. We show that cognitive deficits, speech loss, and motor impairments after severe brain injury are associated with stronger beta band connectivity throughout the brain and suggest that neurological recovery after zolpidem occurs with the restoration of beta band connectivity. This exploratory work proposes an essential role for beta rhythms in goal-directed behavior and cognition. It advocates further fundamental and clinical research on the role of increased beta band connectivity in the development of neurological deficits after severe brain injury.
KW - Awakening
KW - Beta band
KW - Electroencephalography
KW - Functional connectivity
KW - Magnetoencephalography
KW - Oscillations
KW - Severe brain injury
KW - Zolpidem
UR - http://www.scopus.com/inward/record.url?scp=85091393855&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.cortex.2020.08.011
DO - https://doi.org/10.1016/j.cortex.2020.08.011
M3 - Article
C2 - 32979847
SN - 0010-9452
VL - 132
SP - 135
EP - 146
JO - Cortex; a journal devoted to the study of the nervous system and behavior
JF - Cortex; a journal devoted to the study of the nervous system and behavior
ER -