3TR: A pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD

Celeste Porsbjerg; Anke H. Maitland-van der Zee; Guy Brusselle; Giorgio Walter Canonica; Alvar Agusti; Rosa Faner; Claus F. Vogelmeier; Martijn Nawijn; Maarten van den Berge; Franca Rusconi; Charles Pilette; Valeria Ramiconi; Courtney Coleman; Rekha Chaudhuri; Kian Fan Chung; Jadwiga Wedzicha; Sejla Saglani; Marc P. van der Schee; Liam Heaney; Arnaud Bourdin; Graham Roberts; Ratko Djukanovic; Piotr Kuna; Maciej Kupczyk; Judith Axmann; Heribert Staudinger; Graham W. Clarke; Sven Erik Dahlen; Chris Brightling

doi:https://doi.org/10.1183/13993003.02168-2021

3TR: A pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD

Celeste Porsbjerg, Anke H. Maitland-van der Zee, Guy Brusselle, Giorgio Walter Canonica, Alvar Agusti, Rosa Faner, Claus F. Vogelmeier, Martijn Nawijn, Maarten van den Berge, Franca Rusconi, Charles Pilette, Valeria Ramiconi, Courtney Coleman, Rekha Chaudhuri, Kian Fan Chung, Jadwiga Wedzicha, Sejla Saglani, Marc P. van der Schee, Liam Heaney, Arnaud BourdinGraham Roberts, Ratko Djukanovic, Piotr Kuna, Maciej Kupczyk, Judith Axmann, Heribert Staudinger, Graham W. Clarke, Sven Erik Dahlen, Chris Brightling

Research output: Contribution to journal › Review article › Academic › peer-review

8 Citations (Scopus)

Original language	English
Article number	2102168
Journal	European respiratory journal
Volume	58
Issue number	4
DOIs	https://doi.org/10.1183/13993003.02168-2021
Publication status	Published - 1 Oct 2021

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https://doi.org/10.1183/13993003.02168-2021

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Porsbjerg, C., Maitland-van der Zee, A. H., Brusselle, G., Canonica, G. W., Agusti, A., Faner, R., Vogelmeier, C. F., Nawijn, M., van den Berge, M., Rusconi, F., Pilette, C., Ramiconi, V., Coleman, C., Chaudhuri, R., Chung, K. F., Wedzicha, J., Saglani, S., van der Schee, M. P., Heaney, L., ... Brightling, C. (2021). 3TR: A pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD. European respiratory journal, 58(4), Article 2102168. https://doi.org/10.1183/13993003.02168-2021

@article{79fce855d323495994f767809e15739a,

title = "3TR: A pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD",

author = "Celeste Porsbjerg and {Maitland-van der Zee}, {Anke H.} and Guy Brusselle and Canonica, {Giorgio Walter} and Alvar Agusti and Rosa Faner and Vogelmeier, {Claus F.} and Martijn Nawijn and {van den Berge}, Maarten and Franca Rusconi and Charles Pilette and Valeria Ramiconi and Courtney Coleman and Rekha Chaudhuri and Chung, {Kian Fan} and Jadwiga Wedzicha and Sejla Saglani and {van der Schee}, {Marc P.} and Liam Heaney and Arnaud Bourdin and Graham Roberts and Ratko Djukanovic and Piotr Kuna and Maciej Kupczyk and Judith Axmann and Heribert Staudinger and Clarke, {Graham W.} and Dahlen, {Sven Erik} and Chris Brightling",

note = "Funding Information: Conflict of interest: C. Porsbjerg declares grants or contracts, consulting fees and payment or honoraria from AstraZeneca, GlaxoSmithKline, Novartis, TEVA, Sanofi, Chiesi and ALK in the 36 months prior to manuscript submission. A.H. Maitland-van der Zee declares unrestricted research grants from Vertex and Boehringer Ingelheim, and is the principal investigator of a Precision Medicine for more Oxygen (P4O2) public private partnership sponsored by Health Holland involving cash or in kind contributions from Boehringer Ingelheim, Breathomix, Fluidda, Ortec Logiqcare, Philips, Quantib-U, Smartfish, SODAQ, Thirona, TopMD and Novartis; consulting fees paid to their institution by AstraZeneca and Boehringer Ingelheim; and payment or honoraria paid to their institution by GlaxoSmithKline, all in the 36 months prior to manuscript submission. They declare that they are an unpaid member of the Data Safety Monitoring Board of the SOS BPD Study; that they are unpaid president of the Federation of Innovative Drug Research in the Netherlands (FIGON); and that they are president of the European Association of Systems Medicine. G. Brusselle declares payment or honoraria from AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Novartis, Sanofi and Teva in the 36 months prior to manuscript submission. G.W. Canonica declares no competing interests. A. Agusti declares no competing interests. R. Faner declares research grant payments from GlaxoSmithKline, Menarini, AstraZeneca, ISC-III and the Spanish National Health Service; consulting fees from GlaxoSmithKline; and payments or honoraria from Chiesi, all in the 36 months prior to manuscript submission. C.F. Vogelmeier declares grant payments to their institution from the German Ministry of Education and Science (BMBF), AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Grifols and Novartis; consulting fees from AstraZeneca, Boehringer Ingelheim, CSL Behring, Chiesi, GlaxoSmithKline, Menarini, Novartis and Nuvaira; payments or honoraria from Aerogen, AstraZeneca, Boehringer Ingelheim, CSL Behring, Chiesi, GlaxoSmithKline, Menarini and Novartis, all in the 36 months prior to manuscript submission. M. Nawijn declares unrestricted research grant payments to their institution from Chan Zuckerberg Initiative and GlaxoSmithKline in the 36 months prior to manuscript submission; and that they are coordinator of the Human Cell Atlas Lung Biological Network. M. van den Berge declares research grant payments to their institution from GlaxoSmithKline, AstraZeneca, Novartis, Genentech and Roche in the 36 months prior to manuscript submission. F. Rusconi declares no competing interests. C. Pilette declares no competing interests. V. Ramiconi declares unrestricted educational grant payments to her organisation from Novartis, Pfizer, AstraZeneca, Chiesi, GlaxoSmithKline, AbbVie, LeoPharma, Boehringer Ingelheim, Sanofi, Regeneron, OM Pharma, Merck Sharp & Dohme, Roche and DBV Technologies, in the 36 months prior to manuscript submission. C. Coleman is an employee of the European Lung Foundation. R. Chaudhuri declares funding from 3TR European Union Innovative Medicines Initiative 2 to their institution for the present manuscript. They also declare grant funding from AstraZeneca within a Medical Research Council project; lecture fees from GlaxoSmithKline, AstraZeneca, Teva, Chiesi, Sanofi and Novartis; support for attending conferences from Chiesi, Napp, Sanofi, Boehringer Ingelheim, GlaxoSmithKline and AstraZeneca; and participation on advisory boards for GlaxoSmithKline, AstraZeneca, Teva, Chiesi and Novartis, all in the 36 months prior to manuscript submission. K.F. Chung declares grant payments to their institution from the Medical Research Council (precision medicine for severe asthma), the Engineering and Physical Sciences Research Council (air pollution and asthma) and GlaxoSmithKline (eosinophils); consulting fees from the scientific committee of the Clean Breathing Institute (funded by the GlaxoSmithKline consumer division); speaking fees for engagements from Novartis and AstraZeneca; an educational grant paid to their institution for the 11th London International Cough Symposium from AstraZeneca, Merck, Shionogi, Nocion, Bellus and Bayer; participation on a data safety management board for Nocion (antitussive); and participation on advisory boards for Nocion, Shionogi and Merck (antitussives) and GlaxoSmithKline, Roche and Novartis (asthma and COPD), all in the 36 months prior to manuscript submission. J. Wedzicha declares grant payments to their institution from GlaxoSmithKline, AstraZeneca, Novartis, Genentech, Boehringer Ingelheim and Chiesi; paid participation on a Data Safety Monitoring Board for Virtus; and editorship of the American Journal of Respiratory and Critical Care Medicine, for which an honorarium is paid jointly to them and their institution. S. Saglani declares no competing interests. M.P. Van der Schee declares consulting fees from Owlstone Medical in the 36 months prior to manuscript submission; and that they hold stock or stock options in Owlstone Medical and Sanome. L. Heaney declares grant payments to their institution from Novartis UK, GlaxoSmithKline, Amgen, Genentech/Hoffmann la Roche, AstraZeneca, Medimmune, Aerocrine and Vitalograph; payments or honoraria from Novartis, Genentech/Hoffmann la Roche, Sanofi, Evelo Biosciences, GlaxoSmithKline, AstraZeneca, Teva, Theravance and Circassia; support for attending meetings from AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline and Napp; and participation on advisory boards for Novartis, Genentech/Hoffmann la Roche, Sanofi, Evelo Biosciences, GlaxoSmithKline, AstraZeneca, Teva, Theravance and Circassia, all in the 36 months prior to manuscript submission. A. Bourdin declares unrestricted grant payments from AstraZeneca and Boehringer Ingelheim; advisory board fees from AstraZeneca, GlaxoSmithKline, Regeneron, Sanofi, Novartis, Chiesi, Amgen; lecture payments from AstraZeneca, GlaxoSmithKline, Regeneron, Sanofi, Novartis, Chiesi and Amgen; and support for attending meetings from AstraZeneca, GlaxoSmithKline, Regeneron, Sanofi and Novartis, all in the 36 months prior to manuscript submission. G. Roberts declares funding from 3TR European Union Innovative Medicines Initiative 2 to their institution for the present manuscript. R. Djukanovic declares consulting fees from Synairgen plc in the 36 months prior to manuscript submission; that they are chair of the European Respiratory Society Clinical Research Collaboration on severe asthma (SHARP); and that they hold shares in Synairgen plc. P. Kuna declares lecture fees from Adamed, AstraZeneca, Boehringer Ingelheim, Berlin Chimie, Menarini, Chiesi, HAL Allergy, Lekam, Mylan, Novartis, Polpharma and Teva in the 36 months prior to manuscript submission. M. Kupczyk declares funding from 3TR European Union Innovative Medicines Initiative 2 for the present manuscript. They also declare payment or honoraria from AstraZeneca, Chiesi, GlaxoSmithKline, Novartis, Lekam, Alvogen, Emma, Nexter and Berlin Chemie in the 36 months prior to manuscript submission. J. Axmann declares no competing interests. H. Staudinger declares that they are an employee of Sanofi Genzyme; and that they hold stock or stock options in Sanofi and Merck. G.W. Clarke declares that they are an employee of AstraZeneca; and that they hold stock or stock options in AstraZeneca. S.E. Dahlen declares consulting fees from AstraZeneca, Caiman Chemicals, GlaxoSmithKline, Merck, Novartis, Regeneron, Sanofi and Teva, outside the present manuscript. C. Brightling declares support from 3TR European Union Innovative Medicines Initiative 2 for the present manuscript. They also declare grant payments to their institution from GlaxoSmithKline, AstraZeneca, Novartis, Chiesi, Sanofi, Genentech, Merck, Mologic, 4DPharma and Gossamer; consulting fees paid to their institution from GlaxoSmithKline, AstraZeneca, Boehringer Ingelheim, Novartis, Chiesi, Sanofi, Genentech, Merck, Mologic, 4DPharma, Gossamer, TEVA, Regeneron, Roche and CSL Behring, all in the 36 months prior to manuscript submission. Funding Information: Support statement: This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement number 831434 (3TR). The JU receives support from the European Union{\textquoteright}s Horizon 2020 research and innovation program and EFPIA. The content of this publication reflects only the authors{\textquoteright} view and the JU is not responsible for any use that may be made of the information it contains. Funding information for this article has been deposited with the Crossref Funder Registry.",

year = "2021",

month = oct,

day = "1",

doi = "https://doi.org/10.1183/13993003.02168-2021",

language = "English",

volume = "58",

journal = "European respiratory journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "4",

}

Porsbjerg, C, Maitland-van der Zee, AH, Brusselle, G, Canonica, GW, Agusti, A, Faner, R, Vogelmeier, CF, Nawijn, M, van den Berge, M, Rusconi, F, Pilette, C, Ramiconi, V, Coleman, C, Chaudhuri, R, Chung, KF, Wedzicha, J, Saglani, S, van der Schee, MP, Heaney, L, Bourdin, A, Roberts, G, Djukanovic, R, Kuna, P, Kupczyk, M, Axmann, J, Staudinger, H, Clarke, GW, Dahlen, SE & Brightling, C 2021, '3TR: A pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD', European respiratory journal, vol. 58, no. 4, 2102168. https://doi.org/10.1183/13993003.02168-2021

TY - JOUR

T1 - 3TR

T2 - A pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD

AU - Porsbjerg, Celeste

AU - Maitland-van der Zee, Anke H.

AU - Brusselle, Guy

AU - Canonica, Giorgio Walter

AU - Agusti, Alvar

AU - Faner, Rosa

AU - Vogelmeier, Claus F.

AU - Nawijn, Martijn

AU - van den Berge, Maarten

AU - Rusconi, Franca

AU - Pilette, Charles

AU - Ramiconi, Valeria

AU - Coleman, Courtney

AU - Chaudhuri, Rekha

AU - Chung, Kian Fan

AU - Wedzicha, Jadwiga

AU - Saglani, Sejla

AU - van der Schee, Marc P.

AU - Heaney, Liam

AU - Bourdin, Arnaud

AU - Roberts, Graham

AU - Djukanovic, Ratko

AU - Kuna, Piotr

AU - Kupczyk, Maciej

AU - Axmann, Judith

AU - Staudinger, Heribert

AU - Clarke, Graham W.

AU - Dahlen, Sven Erik

AU - Brightling, Chris

N1 - Funding Information: Conflict of interest: C. Porsbjerg declares grants or contracts, consulting fees and payment or honoraria from AstraZeneca, GlaxoSmithKline, Novartis, TEVA, Sanofi, Chiesi and ALK in the 36 months prior to manuscript submission. A.H. Maitland-van der Zee declares unrestricted research grants from Vertex and Boehringer Ingelheim, and is the principal investigator of a Precision Medicine for more Oxygen (P4O2) public private partnership sponsored by Health Holland involving cash or in kind contributions from Boehringer Ingelheim, Breathomix, Fluidda, Ortec Logiqcare, Philips, Quantib-U, Smartfish, SODAQ, Thirona, TopMD and Novartis; consulting fees paid to their institution by AstraZeneca and Boehringer Ingelheim; and payment or honoraria paid to their institution by GlaxoSmithKline, all in the 36 months prior to manuscript submission. They declare that they are an unpaid member of the Data Safety Monitoring Board of the SOS BPD Study; that they are unpaid president of the Federation of Innovative Drug Research in the Netherlands (FIGON); and that they are president of the European Association of Systems Medicine. G. Brusselle declares payment or honoraria from AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Novartis, Sanofi and Teva in the 36 months prior to manuscript submission. G.W. Canonica declares no competing interests. A. Agusti declares no competing interests. R. Faner declares research grant payments from GlaxoSmithKline, Menarini, AstraZeneca, ISC-III and the Spanish National Health Service; consulting fees from GlaxoSmithKline; and payments or honoraria from Chiesi, all in the 36 months prior to manuscript submission. C.F. Vogelmeier declares grant payments to their institution from the German Ministry of Education and Science (BMBF), AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Grifols and Novartis; consulting fees from AstraZeneca, Boehringer Ingelheim, CSL Behring, Chiesi, GlaxoSmithKline, Menarini, Novartis and Nuvaira; payments or honoraria from Aerogen, AstraZeneca, Boehringer Ingelheim, CSL Behring, Chiesi, GlaxoSmithKline, Menarini and Novartis, all in the 36 months prior to manuscript submission. M. Nawijn declares unrestricted research grant payments to their institution from Chan Zuckerberg Initiative and GlaxoSmithKline in the 36 months prior to manuscript submission; and that they are coordinator of the Human Cell Atlas Lung Biological Network. M. van den Berge declares research grant payments to their institution from GlaxoSmithKline, AstraZeneca, Novartis, Genentech and Roche in the 36 months prior to manuscript submission. F. Rusconi declares no competing interests. C. Pilette declares no competing interests. V. Ramiconi declares unrestricted educational grant payments to her organisation from Novartis, Pfizer, AstraZeneca, Chiesi, GlaxoSmithKline, AbbVie, LeoPharma, Boehringer Ingelheim, Sanofi, Regeneron, OM Pharma, Merck Sharp & Dohme, Roche and DBV Technologies, in the 36 months prior to manuscript submission. C. Coleman is an employee of the European Lung Foundation. R. Chaudhuri declares funding from 3TR European Union Innovative Medicines Initiative 2 to their institution for the present manuscript. They also declare grant funding from AstraZeneca within a Medical Research Council project; lecture fees from GlaxoSmithKline, AstraZeneca, Teva, Chiesi, Sanofi and Novartis; support for attending conferences from Chiesi, Napp, Sanofi, Boehringer Ingelheim, GlaxoSmithKline and AstraZeneca; and participation on advisory boards for GlaxoSmithKline, AstraZeneca, Teva, Chiesi and Novartis, all in the 36 months prior to manuscript submission. K.F. Chung declares grant payments to their institution from the Medical Research Council (precision medicine for severe asthma), the Engineering and Physical Sciences Research Council (air pollution and asthma) and GlaxoSmithKline (eosinophils); consulting fees from the scientific committee of the Clean Breathing Institute (funded by the GlaxoSmithKline consumer division); speaking fees for engagements from Novartis and AstraZeneca; an educational grant paid to their institution for the 11th London International Cough Symposium from AstraZeneca, Merck, Shionogi, Nocion, Bellus and Bayer; participation on a data safety management board for Nocion (antitussive); and participation on advisory boards for Nocion, Shionogi and Merck (antitussives) and GlaxoSmithKline, Roche and Novartis (asthma and COPD), all in the 36 months prior to manuscript submission. J. Wedzicha declares grant payments to their institution from GlaxoSmithKline, AstraZeneca, Novartis, Genentech, Boehringer Ingelheim and Chiesi; paid participation on a Data Safety Monitoring Board for Virtus; and editorship of the American Journal of Respiratory and Critical Care Medicine, for which an honorarium is paid jointly to them and their institution. S. Saglani declares no competing interests. M.P. Van der Schee declares consulting fees from Owlstone Medical in the 36 months prior to manuscript submission; and that they hold stock or stock options in Owlstone Medical and Sanome. L. Heaney declares grant payments to their institution from Novartis UK, GlaxoSmithKline, Amgen, Genentech/Hoffmann la Roche, AstraZeneca, Medimmune, Aerocrine and Vitalograph; payments or honoraria from Novartis, Genentech/Hoffmann la Roche, Sanofi, Evelo Biosciences, GlaxoSmithKline, AstraZeneca, Teva, Theravance and Circassia; support for attending meetings from AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline and Napp; and participation on advisory boards for Novartis, Genentech/Hoffmann la Roche, Sanofi, Evelo Biosciences, GlaxoSmithKline, AstraZeneca, Teva, Theravance and Circassia, all in the 36 months prior to manuscript submission. A. Bourdin declares unrestricted grant payments from AstraZeneca and Boehringer Ingelheim; advisory board fees from AstraZeneca, GlaxoSmithKline, Regeneron, Sanofi, Novartis, Chiesi, Amgen; lecture payments from AstraZeneca, GlaxoSmithKline, Regeneron, Sanofi, Novartis, Chiesi and Amgen; and support for attending meetings from AstraZeneca, GlaxoSmithKline, Regeneron, Sanofi and Novartis, all in the 36 months prior to manuscript submission. G. Roberts declares funding from 3TR European Union Innovative Medicines Initiative 2 to their institution for the present manuscript. R. Djukanovic declares consulting fees from Synairgen plc in the 36 months prior to manuscript submission; that they are chair of the European Respiratory Society Clinical Research Collaboration on severe asthma (SHARP); and that they hold shares in Synairgen plc. P. Kuna declares lecture fees from Adamed, AstraZeneca, Boehringer Ingelheim, Berlin Chimie, Menarini, Chiesi, HAL Allergy, Lekam, Mylan, Novartis, Polpharma and Teva in the 36 months prior to manuscript submission. M. Kupczyk declares funding from 3TR European Union Innovative Medicines Initiative 2 for the present manuscript. They also declare payment or honoraria from AstraZeneca, Chiesi, GlaxoSmithKline, Novartis, Lekam, Alvogen, Emma, Nexter and Berlin Chemie in the 36 months prior to manuscript submission. J. Axmann declares no competing interests. H. Staudinger declares that they are an employee of Sanofi Genzyme; and that they hold stock or stock options in Sanofi and Merck. G.W. Clarke declares that they are an employee of AstraZeneca; and that they hold stock or stock options in AstraZeneca. S.E. Dahlen declares consulting fees from AstraZeneca, Caiman Chemicals, GlaxoSmithKline, Merck, Novartis, Regeneron, Sanofi and Teva, outside the present manuscript. C. Brightling declares support from 3TR European Union Innovative Medicines Initiative 2 for the present manuscript. They also declare grant payments to their institution from GlaxoSmithKline, AstraZeneca, Novartis, Chiesi, Sanofi, Genentech, Merck, Mologic, 4DPharma and Gossamer; consulting fees paid to their institution from GlaxoSmithKline, AstraZeneca, Boehringer Ingelheim, Novartis, Chiesi, Sanofi, Genentech, Merck, Mologic, 4DPharma, Gossamer, TEVA, Regeneron, Roche and CSL Behring, all in the 36 months prior to manuscript submission. Funding Information: Support statement: This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement number 831434 (3TR). The JU receives support from the European Union’s Horizon 2020 research and innovation program and EFPIA. The content of this publication reflects only the authors’ view and the JU is not responsible for any use that may be made of the information it contains. Funding information for this article has been deposited with the Crossref Funder Registry.

PY - 2021/10/1

Y1 - 2021/10/1

UR - http://www.scopus.com/inward/record.url?scp=85119127817&partnerID=8YFLogxK

U2 - https://doi.org/10.1183/13993003.02168-2021

DO - https://doi.org/10.1183/13993003.02168-2021

M3 - Review article

C2 - 34675035

SN - 0903-1936

VL - 58

JO - European respiratory journal

JF - European respiratory journal

IS - 4

M1 - 2102168

ER -

3TR: A pan-European cross-disease research consortium aimed at improving personalised biological treatment of asthma and COPD

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