Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis

Federico Oldoni; Damiano Baldassarre; Samuela Castelnuovo; Alice Ossoli; Mauro Amato; Julian van Capelleveen; G. Kees Hovingh; Eric de Groot; Andrea Bochem; Sara Simonelli; Simone Barbieri; Fabrizio Veglia; Guido Franceschini; Jan Albert Kuivenhoven; Adriaan G. Holleboom; Laura Calabresi

doi:https://doi.org/10.1161/CIRCULATIONAHA.118.034706

Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis

Federico Oldoni, Damiano Baldassarre, Samuela Castelnuovo, Alice Ossoli, Mauro Amato, Julian van Capelleveen, G. Kees Hovingh, Eric de Groot, Andrea Bochem, Sara Simonelli, Simone Barbieri, Fabrizio Veglia, Guido Franceschini, Jan Albert Kuivenhoven, Adriaan G. Holleboom, Laura Calabresi

Research output: Contribution to journal › Article › Academic › peer-review

51 Citations (Scopus)

Abstract

BACKGROUND: Lecithin:cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma. Its role in the supposed protection from atherogenesis remains unclear because mutations in LCAT causing fish-eye disease (FED) or familial LCAT deficiency (FLD) have been reported to be associated with more or instead less carotid atherosclerosis, respectively. This discrepancy may be associated with the loss of cholesterol esterification on only apolipoprotein AI (FED) or on both apolipoprotein AI- and apolipoprotein B-containing lipoproteins (FLD), an aspect that has thus far not been investigated.

Original language	English
Pages (from-to)	1000-1007
Journal	Circulation
Volume	138
Issue number	10
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.118.034706
Publication status	Published - 2018

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Oldoni, F., Baldassarre, D., Castelnuovo, S., Ossoli, A., Amato, M., van Capelleveen, J., Hovingh, G. K., de Groot, E., Bochem, A., Simonelli, S., Barbieri, S., Veglia, F., Franceschini, G., Kuivenhoven, J. A., Holleboom, A. G., & Calabresi, L. (2018). Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis. Circulation, 138(10), 1000-1007. https://doi.org/10.1161/CIRCULATIONAHA.118.034706

@article{404237409df14c088069ee1df92167c5,

title = "Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis",

abstract = "BACKGROUND: Lecithin:cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma. Its role in the supposed protection from atherogenesis remains unclear because mutations in LCAT causing fish-eye disease (FED) or familial LCAT deficiency (FLD) have been reported to be associated with more or instead less carotid atherosclerosis, respectively. This discrepancy may be associated with the loss of cholesterol esterification on only apolipoprotein AI (FED) or on both apolipoprotein AI- and apolipoprotein B-containing lipoproteins (FLD), an aspect that has thus far not been investigated.",

author = "Federico Oldoni and Damiano Baldassarre and Samuela Castelnuovo and Alice Ossoli and Mauro Amato and {van Capelleveen}, Julian and Hovingh, {G. Kees} and {de Groot}, Eric and Andrea Bochem and Sara Simonelli and Simone Barbieri and Fabrizio Veglia and Guido Franceschini and Kuivenhoven, {Jan Albert} and Holleboom, {Adriaan G.} and Laura Calabresi",

year = "2018",

doi = "https://doi.org/10.1161/CIRCULATIONAHA.118.034706",

language = "English",

volume = "138",

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journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins Ltd.",

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Oldoni, F, Baldassarre, D, Castelnuovo, S, Ossoli, A, Amato, M, van Capelleveen, J , Hovingh, GK, de Groot, E, Bochem, A, Simonelli, S, Barbieri, S, Veglia, F, Franceschini, G, Kuivenhoven, JA, Holleboom, AG & Calabresi, L 2018, 'Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis', Circulation, vol. 138, no. 10, pp. 1000-1007. https://doi.org/10.1161/CIRCULATIONAHA.118.034706

TY - JOUR

T1 - Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis

AU - Oldoni, Federico

AU - Baldassarre, Damiano

AU - Castelnuovo, Samuela

AU - Ossoli, Alice

AU - Amato, Mauro

AU - van Capelleveen, Julian

AU - Hovingh, G. Kees

AU - de Groot, Eric

AU - Bochem, Andrea

AU - Simonelli, Sara

AU - Barbieri, Simone

AU - Veglia, Fabrizio

AU - Franceschini, Guido

AU - Kuivenhoven, Jan Albert

AU - Holleboom, Adriaan G.

AU - Calabresi, Laura

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Lecithin:cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma. Its role in the supposed protection from atherogenesis remains unclear because mutations in LCAT causing fish-eye disease (FED) or familial LCAT deficiency (FLD) have been reported to be associated with more or instead less carotid atherosclerosis, respectively. This discrepancy may be associated with the loss of cholesterol esterification on only apolipoprotein AI (FED) or on both apolipoprotein AI- and apolipoprotein B-containing lipoproteins (FLD), an aspect that has thus far not been investigated.

AB - BACKGROUND: Lecithin:cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma. Its role in the supposed protection from atherogenesis remains unclear because mutations in LCAT causing fish-eye disease (FED) or familial LCAT deficiency (FLD) have been reported to be associated with more or instead less carotid atherosclerosis, respectively. This discrepancy may be associated with the loss of cholesterol esterification on only apolipoprotein AI (FED) or on both apolipoprotein AI- and apolipoprotein B-containing lipoproteins (FLD), an aspect that has thus far not been investigated.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85053622647&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/29748187

U2 - https://doi.org/10.1161/CIRCULATIONAHA.118.034706

DO - https://doi.org/10.1161/CIRCULATIONAHA.118.034706

M3 - Article

C2 - 29748187

SN - 0009-7322

VL - 138

SP - 1000

EP - 1007

JO - Circulation

JF - Circulation

IS - 10

ER -

Complete and Partial Lecithin:Cholesterol Acyltransferase Deficiency Is Differentially Associated With Atherosclerosis

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