TY - JOUR
T1 - Endothelial cells: From innocent bystanders to active participants in immune responses
AU - Al-Soudi, A.
AU - Kaaij, M. H.
AU - Tas, S. W.
PY - 2017
Y1 - 2017
N2 - The endothelium is crucially important for the delivery of oxygen and nutrients throughout the body under homeostatic conditions. However, it also contributes to pathology, including the initiation and perpetuation of inflammation. Understanding the function of endothelial cells (ECs) in inflammatory diseases and molecular mechanisms involved may lead to novel approaches to dampen inflammation and restore homeostasis. In this article, we discuss the various functions of ECs in inflammation with a focus on pathological angiogenesis, attraction of immune cells, antigen presentation, immunoregulatory properties and endothelial-to-mesenchymal transition (EndMT). We also review the current literature on approaches to target these processes in ECs to modulate immune responses and advance anti-inflammatory therapies
AB - The endothelium is crucially important for the delivery of oxygen and nutrients throughout the body under homeostatic conditions. However, it also contributes to pathology, including the initiation and perpetuation of inflammation. Understanding the function of endothelial cells (ECs) in inflammatory diseases and molecular mechanisms involved may lead to novel approaches to dampen inflammation and restore homeostasis. In this article, we discuss the various functions of ECs in inflammation with a focus on pathological angiogenesis, attraction of immune cells, antigen presentation, immunoregulatory properties and endothelial-to-mesenchymal transition (EndMT). We also review the current literature on approaches to target these processes in ECs to modulate immune responses and advance anti-inflammatory therapies
U2 - https://doi.org/10.1016/j.autrev.2017.07.008
DO - https://doi.org/10.1016/j.autrev.2017.07.008
M3 - Review article
C2 - 28698091
SN - 1568-9972
VL - 16
SP - 951
EP - 962
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 9
ER -