Externe validatie van de Prostaatwijzer binnen een Nederlands klinisch hoogrisicocohort

Marinus J. Hagens; Piter J. Stelwagen; Hans Veerman; Sybren P. Rynja; Martijn Smeenge; Vincent van der Noort; Ton A. Roeleveld; Jolien van Kesteren; Sebastiaan Remmers; Monique J. Roobol; Pim J. van Leeuwen; Henk G. van der Poel

doi:https://doi.org/10.1007/s13629-023-00391-4

Externe validatie van de Prostaatwijzer binnen een Nederlands klinisch hoogrisicocohort

Translated title of the contribution: External validation of the Rotterdam Prostate Cancer Risk Calculator within a Dutch high-risk clinical cohort

Marinus J. Hagens, Piter J. Stelwagen, Hans Veerman, Sybren P. Rynja, Martijn Smeenge, Vincent van der Noort, Ton A. Roeleveld, Jolien van Kesteren, Sebastiaan Remmers, Monique J. Roobol, Pim J. van Leeuwen, Henk G. van der Poel

Urology (VUmc)

Research output: Contribution to journal › Article › Professional

Abstract

The positive effect of the Rotterdam Prostate Cancer Risk Calculator (RPCRC)-3/4 and RPCRC-MRI has already been confirmed. Nevertheless, its performance and applicability in clinical practice are still questioned. This study performs an external validation of the RPCRC-3/4 and -MRI within a Dutch clinical high-risk cohort. Men (n = 1,575) subjected to prostate biopsies between 2018 and 2021 due to a clinical suspicion of prostate cancer (PCa) were retrospectively included. PCa and clinically significant PCa (csPCa) were diagnosed in 996/1,575 (63.2%) and 656/1,575 (41.7%) men, respectively. The analysis showed that the RPCRC-3/4 underestimates the risk of csPCa within this Dutch high-risk clinical cohort: even though the RPCRC-3/4 could have prevented 37.3% of all MRIs, 18.3% of csPCa diagnoses would have been consequently missed. Recalibration of this risk calculator and adjustment of its risk thresholds was therefore indicated. The RPCRC-MRI, on the other hand, performed adequately and recalibration was not necessary.

Translated title of the contribution	External validation of the Rotterdam Prostate Cancer Risk Calculator within a Dutch high-risk clinical cohort
Original language	Dutch
Pages (from-to)	98-105
Number of pages	8
Journal	Tijdschrift voor Urologie
Volume	13
Issue number	5
Early online date	2023
DOIs	https://doi.org/10.1007/s13629-023-00391-4
Publication status	Published - Aug 2023

Keywords

magnetic resonance imaging (MRI)
prostate biopsies
prostate cancer
riskstratification

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Hagens, M. J., Stelwagen, P. J., Veerman, H., Rynja, S. P., Smeenge, M., van der Noort, V., Roeleveld, T. A., van Kesteren, J., Remmers, S., Roobol, M. J., van Leeuwen, P. J., & van der Poel, H. G. (2023). Externe validatie van de Prostaatwijzer binnen een Nederlands klinisch hoogrisicocohort. Tijdschrift voor Urologie, 13(5), 98-105. https://doi.org/10.1007/s13629-023-00391-4

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title = "Externe validatie van de Prostaatwijzer binnen een Nederlands klinisch hoogrisicocohort",

abstract = "The positive effect of the Rotterdam Prostate Cancer Risk Calculator (RPCRC)-3/4 and RPCRC-MRI has already been confirmed. Nevertheless, its performance and applicability in clinical practice are still questioned. This study performs an external validation of the RPCRC-3/4 and -MRI within a Dutch clinical high-risk cohort. Men (n = 1,575) subjected to prostate biopsies between 2018 and 2021 due to a clinical suspicion of prostate cancer (PCa) were retrospectively included. PCa and clinically significant PCa (csPCa) were diagnosed in 996/1,575 (63.2%) and 656/1,575 (41.7%) men, respectively. The analysis showed that the RPCRC-3/4 underestimates the risk of csPCa within this Dutch high-risk clinical cohort: even though the RPCRC-3/4 could have prevented 37.3% of all MRIs, 18.3% of csPCa diagnoses would have been consequently missed. Recalibration of this risk calculator and adjustment of its risk thresholds was therefore indicated. The RPCRC-MRI, on the other hand, performed adequately and recalibration was not necessary.",

keywords = "magnetic resonance imaging (MRI), prostate biopsies, prostate cancer, riskstratification",

author = "Hagens, {Marinus J.} and Stelwagen, {Piter J.} and Hans Veerman and Rynja, {Sybren P.} and Martijn Smeenge and {van der Noort}, Vincent and Roeleveld, {Ton A.} and {van Kesteren}, Jolien and Sebastiaan Remmers and Roobol, {Monique J.} and {van Leeuwen}, {Pim J.} and {van der Poel}, {Henk G.}",

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month = aug,

doi = "https://doi.org/10.1007/s13629-023-00391-4",

language = "Dutch",

volume = "13",

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AU - Hagens, Marinus J.

AU - Stelwagen, Piter J.

AU - Veerman, Hans

AU - Rynja, Sybren P.

AU - Smeenge, Martijn

AU - van der Noort, Vincent

AU - Roeleveld, Ton A.

AU - van Kesteren, Jolien

AU - Remmers, Sebastiaan

AU - Roobol, Monique J.

AU - van Leeuwen, Pim J.

AU - van der Poel, Henk G.

PY - 2023/8

Y1 - 2023/8

N2 - The positive effect of the Rotterdam Prostate Cancer Risk Calculator (RPCRC)-3/4 and RPCRC-MRI has already been confirmed. Nevertheless, its performance and applicability in clinical practice are still questioned. This study performs an external validation of the RPCRC-3/4 and -MRI within a Dutch clinical high-risk cohort. Men (n = 1,575) subjected to prostate biopsies between 2018 and 2021 due to a clinical suspicion of prostate cancer (PCa) were retrospectively included. PCa and clinically significant PCa (csPCa) were diagnosed in 996/1,575 (63.2%) and 656/1,575 (41.7%) men, respectively. The analysis showed that the RPCRC-3/4 underestimates the risk of csPCa within this Dutch high-risk clinical cohort: even though the RPCRC-3/4 could have prevented 37.3% of all MRIs, 18.3% of csPCa diagnoses would have been consequently missed. Recalibration of this risk calculator and adjustment of its risk thresholds was therefore indicated. The RPCRC-MRI, on the other hand, performed adequately and recalibration was not necessary.

AB - The positive effect of the Rotterdam Prostate Cancer Risk Calculator (RPCRC)-3/4 and RPCRC-MRI has already been confirmed. Nevertheless, its performance and applicability in clinical practice are still questioned. This study performs an external validation of the RPCRC-3/4 and -MRI within a Dutch clinical high-risk cohort. Men (n = 1,575) subjected to prostate biopsies between 2018 and 2021 due to a clinical suspicion of prostate cancer (PCa) were retrospectively included. PCa and clinically significant PCa (csPCa) were diagnosed in 996/1,575 (63.2%) and 656/1,575 (41.7%) men, respectively. The analysis showed that the RPCRC-3/4 underestimates the risk of csPCa within this Dutch high-risk clinical cohort: even though the RPCRC-3/4 could have prevented 37.3% of all MRIs, 18.3% of csPCa diagnoses would have been consequently missed. Recalibration of this risk calculator and adjustment of its risk thresholds was therefore indicated. The RPCRC-MRI, on the other hand, performed adequately and recalibration was not necessary.

KW - magnetic resonance imaging (MRI)

KW - prostate biopsies

KW - prostate cancer

KW - riskstratification

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ER -

Externe validatie van de Prostaatwijzer binnen een Nederlands klinisch hoogrisicocohort

Abstract

Keywords

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