Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options

Marieke van der Pluijm; Elon D. Wallert; Bram F. Coolen; Kaithlyn T. Tjong Tjin Joe; Lieuwe de Haan; Jan Booij; Elsmarieke van de Giessen

doi:https://doi.org/10.1007/s00234-022-03058-w

Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options

Marieke van der Pluijm, Elon D. Wallert, Bram F. Coolen, Kaithlyn T. Tjong Tjin Joe, Lieuwe de Haan, Jan Booij, Elsmarieke van de Giessen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose: Neuromelanin MRI (NM-MRI) is applied as a proxy measurement of dopaminergic functioning of the substantia nigra pars compacta (SN). To increase its clinical applicability, a fast and easily applicable NM-MRI sequence is needed. This study therefore compared accelerated NM-MRI sequences using standard available MRI options with a validated 2D gradient recalled echo NM-MRI sequence with off-resonance magnetization transfer (MT) pulse (2D-MToffRes). Methods: We used different combinations of compressed sense (CS) acceleration, repetition times (TR), and MT pulse to accelerate the validated 2D-MToffRes. In addition, we compared a recently introduced 3D sequence with the 2D-MToffRes. Results: Our results show that the 2D sequences perform best with good to excellent reliability. Only excellent intraclass correlation coefficients were found for the CS factor 2 sequences. Conclusion: We conclude that there are several reliable approaches to accelerate NM-MRI, in particular by using CS.

Original language	English
Journal	Neuroradiology
Early online date	2022
DOIs	https://doi.org/10.1007/s00234-022-03058-w
Publication status	E-pub ahead of print - 2022

Keywords

Acceleration
Neuromelanin
Reliability
Substantia nigra

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https://doi.org/10.1007/s00234-022-03058-w

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@article{48a173a42a5e44008caa84b1f237ade8,

title = "Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options",

abstract = "Purpose: Neuromelanin MRI (NM-MRI) is applied as a proxy measurement of dopaminergic functioning of the substantia nigra pars compacta (SN). To increase its clinical applicability, a fast and easily applicable NM-MRI sequence is needed. This study therefore compared accelerated NM-MRI sequences using standard available MRI options with a validated 2D gradient recalled echo NM-MRI sequence with off-resonance magnetization transfer (MT) pulse (2D-MToffRes). Methods: We used different combinations of compressed sense (CS) acceleration, repetition times (TR), and MT pulse to accelerate the validated 2D-MToffRes. In addition, we compared a recently introduced 3D sequence with the 2D-MToffRes. Results: Our results show that the 2D sequences perform best with good to excellent reliability. Only excellent intraclass correlation coefficients were found for the CS factor 2 sequences. Conclusion: We conclude that there are several reliable approaches to accelerate NM-MRI, in particular by using CS.",

keywords = "Acceleration, Neuromelanin, Reliability, Substantia nigra",

author = "{van der Pluijm}, Marieke and Wallert, {Elon D.} and Coolen, {Bram F.} and {Tjong Tjin Joe}, {Kaithlyn T.} and {de Haan}, Lieuwe and Jan Booij and {van de Giessen}, Elsmarieke",

note = "Funding Information: The study was funded by a Veni grant (91618075) from the Netherlands Organisation for Health Research and Development (ZonMw). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

doi = "https://doi.org/10.1007/s00234-022-03058-w",

language = "English",

journal = "Neuroradiology",

issn = "0028-3940",

publisher = "Springer Verlag",

}

TY - JOUR

T1 - Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options

AU - van der Pluijm, Marieke

AU - Wallert, Elon D.

AU - Coolen, Bram F.

AU - Tjong Tjin Joe, Kaithlyn T.

AU - de Haan, Lieuwe

AU - Booij, Jan

AU - van de Giessen, Elsmarieke

N1 - Funding Information: The study was funded by a Veni grant (91618075) from the Netherlands Organisation for Health Research and Development (ZonMw). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022, The Author(s).

PY - 2022

Y1 - 2022

N2 - Purpose: Neuromelanin MRI (NM-MRI) is applied as a proxy measurement of dopaminergic functioning of the substantia nigra pars compacta (SN). To increase its clinical applicability, a fast and easily applicable NM-MRI sequence is needed. This study therefore compared accelerated NM-MRI sequences using standard available MRI options with a validated 2D gradient recalled echo NM-MRI sequence with off-resonance magnetization transfer (MT) pulse (2D-MToffRes). Methods: We used different combinations of compressed sense (CS) acceleration, repetition times (TR), and MT pulse to accelerate the validated 2D-MToffRes. In addition, we compared a recently introduced 3D sequence with the 2D-MToffRes. Results: Our results show that the 2D sequences perform best with good to excellent reliability. Only excellent intraclass correlation coefficients were found for the CS factor 2 sequences. Conclusion: We conclude that there are several reliable approaches to accelerate NM-MRI, in particular by using CS.

AB - Purpose: Neuromelanin MRI (NM-MRI) is applied as a proxy measurement of dopaminergic functioning of the substantia nigra pars compacta (SN). To increase its clinical applicability, a fast and easily applicable NM-MRI sequence is needed. This study therefore compared accelerated NM-MRI sequences using standard available MRI options with a validated 2D gradient recalled echo NM-MRI sequence with off-resonance magnetization transfer (MT) pulse (2D-MToffRes). Methods: We used different combinations of compressed sense (CS) acceleration, repetition times (TR), and MT pulse to accelerate the validated 2D-MToffRes. In addition, we compared a recently introduced 3D sequence with the 2D-MToffRes. Results: Our results show that the 2D sequences perform best with good to excellent reliability. Only excellent intraclass correlation coefficients were found for the CS factor 2 sequences. Conclusion: We conclude that there are several reliable approaches to accelerate NM-MRI, in particular by using CS.

KW - Acceleration

KW - Neuromelanin

KW - Reliability

KW - Substantia nigra

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U2 - https://doi.org/10.1007/s00234-022-03058-w

DO - https://doi.org/10.1007/s00234-022-03058-w

M3 - Article

C2 - 36169662

SN - 0028-3940

JO - Neuroradiology

JF - Neuroradiology

ER -

Acceleration of neuromelanin-sensitive MRI sequences in the substantia nigra using standard MRI options

Abstract

Keywords

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