Familial hypercholesterolemia in children and the importance of early treatment

Sibbeliene E van den Bosch; Barbara A Hutten; Willemijn E Corpeleijn; D Meeike Kusters

doi:10.1097/MOL.0000000000000926

Familial hypercholesterolemia in children and the importance of early treatment

Sibbeliene E van den Bosch, Barbara A Hutten, Willemijn E Corpeleijn, D Meeike Kusters

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE OF REVIEW: Familial hypercholesterolemia leads to elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth onwards due to a pathogenetic variation in genes in cholesterol metabolism. Early screening to identify and subsequently treat children with familial hypercholesterolemia is crucial to reduce the risk of premature atherosclerotic cardiovascular disease (ASCVD). This review focuses on recent insights in the field of pediatric familial hypercholesterolemia.

RECENT FINDINGS: Screening in childhood and early initiation of optimal lipid-lowering therapy (LLT) have shown promising outcomes in the prevention of ASCVD. In addition, cost-effectiveness research has demonstrated highly favorable results. With the availability of novel therapies, familial hypercholesterolemia has become a well treatable disease.

SUMMARY: Children with familial hypercholesterolemia benefit from early detection and optimal treatment of their elevated LDL-C levels.

Original language	English
Journal	Current opinion in lipidology
DOIs	https://doi.org/10.1097/MOL.0000000000000926
Publication status	E-pub ahead of print - 15 Feb 2024

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10.1097/MOL.0000000000000926

Cite this

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title = "Familial hypercholesterolemia in children and the importance of early treatment",

abstract = "PURPOSE OF REVIEW: Familial hypercholesterolemia leads to elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth onwards due to a pathogenetic variation in genes in cholesterol metabolism. Early screening to identify and subsequently treat children with familial hypercholesterolemia is crucial to reduce the risk of premature atherosclerotic cardiovascular disease (ASCVD). This review focuses on recent insights in the field of pediatric familial hypercholesterolemia.RECENT FINDINGS: Screening in childhood and early initiation of optimal lipid-lowering therapy (LLT) have shown promising outcomes in the prevention of ASCVD. In addition, cost-effectiveness research has demonstrated highly favorable results. With the availability of novel therapies, familial hypercholesterolemia has become a well treatable disease.SUMMARY: Children with familial hypercholesterolemia benefit from early detection and optimal treatment of their elevated LDL-C levels.",

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AU - van den Bosch, Sibbeliene E

AU - Hutten, Barbara A

AU - Corpeleijn, Willemijn E

AU - Kusters, D Meeike

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N2 - PURPOSE OF REVIEW: Familial hypercholesterolemia leads to elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth onwards due to a pathogenetic variation in genes in cholesterol metabolism. Early screening to identify and subsequently treat children with familial hypercholesterolemia is crucial to reduce the risk of premature atherosclerotic cardiovascular disease (ASCVD). This review focuses on recent insights in the field of pediatric familial hypercholesterolemia.RECENT FINDINGS: Screening in childhood and early initiation of optimal lipid-lowering therapy (LLT) have shown promising outcomes in the prevention of ASCVD. In addition, cost-effectiveness research has demonstrated highly favorable results. With the availability of novel therapies, familial hypercholesterolemia has become a well treatable disease.SUMMARY: Children with familial hypercholesterolemia benefit from early detection and optimal treatment of their elevated LDL-C levels.

AB - PURPOSE OF REVIEW: Familial hypercholesterolemia leads to elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth onwards due to a pathogenetic variation in genes in cholesterol metabolism. Early screening to identify and subsequently treat children with familial hypercholesterolemia is crucial to reduce the risk of premature atherosclerotic cardiovascular disease (ASCVD). This review focuses on recent insights in the field of pediatric familial hypercholesterolemia.RECENT FINDINGS: Screening in childhood and early initiation of optimal lipid-lowering therapy (LLT) have shown promising outcomes in the prevention of ASCVD. In addition, cost-effectiveness research has demonstrated highly favorable results. With the availability of novel therapies, familial hypercholesterolemia has become a well treatable disease.SUMMARY: Children with familial hypercholesterolemia benefit from early detection and optimal treatment of their elevated LDL-C levels.

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