TY - JOUR
T1 - Impact of undernutrition on the pharmacokinetics of chemotherapy in children with cancer
T2 - A systematic review
AU - Schoon, Sterre
AU - Makamo, Nthongase
AU - Uittenboogaard, Aniek
AU - Bernhardt, Melanie B.
AU - Ozuah, Nmazuo W.
AU - Kaspers, Gertjan J. L.
AU - Huibers, Minke H. W.
N1 - Publisher Copyright: © 2023 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Objectives: This systematic review provides an overview of the effect of undernutrition on the pharmacokinetics of chemotherapy in children with cancer. Methods: PubMed, Embase, and Cochrane were searched to identify eligible studies. This study uses the definition for undernutrition from the World Health Organization and the Gomez classification. Results: Four studies with a total of 668 children with cancer were included and n = 121 (18%) were undernourished. Significant decreased clearance rates were found for vincristine in undernourished children compared to children with a normal nutritional status. Conclusion: Presenting outcomes only show significant changes in the pharmacokinetics of vincristine in undernourished children with cancer. However, data are scarce, groups were small, and none of the studies included severely undernourished children. In order to improve outcomes for (severely) undernourished children with cancer, more pharmacokinetic research is needed. The ultimate goal would be to develop subgroups, and ultimately individualized drug dosing in order to improve outcomes for children with cancer worldwide.
AB - Objectives: This systematic review provides an overview of the effect of undernutrition on the pharmacokinetics of chemotherapy in children with cancer. Methods: PubMed, Embase, and Cochrane were searched to identify eligible studies. This study uses the definition for undernutrition from the World Health Organization and the Gomez classification. Results: Four studies with a total of 668 children with cancer were included and n = 121 (18%) were undernourished. Significant decreased clearance rates were found for vincristine in undernourished children compared to children with a normal nutritional status. Conclusion: Presenting outcomes only show significant changes in the pharmacokinetics of vincristine in undernourished children with cancer. However, data are scarce, groups were small, and none of the studies included severely undernourished children. In order to improve outcomes for (severely) undernourished children with cancer, more pharmacokinetic research is needed. The ultimate goal would be to develop subgroups, and ultimately individualized drug dosing in order to improve outcomes for children with cancer worldwide.
KW - cancer
KW - children
KW - pediatric oncology
KW - pharmacokinetics
KW - undernutrition
UR - http://www.scopus.com/inward/record.url?scp=85164150491&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/pbc.30531
DO - https://doi.org/10.1002/pbc.30531
M3 - Article
C2 - 37393425
SN - 1545-5009
VL - 70
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 9
M1 - e30531
ER -