TY - THES
T1 - Modulators of metabolism
T2 - Pathways to insulin resistance
AU - Kiliçarslan, M.
PY - 2020
Y1 - 2020
N2 - The prevalence of obesity has increased worldwide the last several decades. Obesity is associated with complications such as type 2 diabetes, hypertension, and dyslipidemia, and as a result, obesity is associated with increased mortality. One of the major underlying mechanisms by which obesity leads to its complications is the development of insulin resistance, i.e. the diminished biological response to insulin. The only treatment modality that has been proven effective in the long term is bariatric surgery. In this thesis, we aimed to investigate some of the pathways and mechanisms that contribute to obesity-induced insulin resistance. In addition, we studied the effect of bariatric surgery-induced weight loss on some of these parameters as well as which clinical parameters predict the metabolic success of this type of surgery in the long term.
AB - The prevalence of obesity has increased worldwide the last several decades. Obesity is associated with complications such as type 2 diabetes, hypertension, and dyslipidemia, and as a result, obesity is associated with increased mortality. One of the major underlying mechanisms by which obesity leads to its complications is the development of insulin resistance, i.e. the diminished biological response to insulin. The only treatment modality that has been proven effective in the long term is bariatric surgery. In this thesis, we aimed to investigate some of the pathways and mechanisms that contribute to obesity-induced insulin resistance. In addition, we studied the effect of bariatric surgery-induced weight loss on some of these parameters as well as which clinical parameters predict the metabolic success of this type of surgery in the long term.
KW - Caloric Restriction
KW - Life Span
KW - Metabolism
KW - Resveratrol
KW - Sirtuins
UR - https://pure.uva.nl/ws/files/53267048/Licentieovereenkomst_medeondertekend_.pdf
UR - https://pure.uva.nl/ws/files/53267050/Stellingen.pdf
UR - https://pure.uva.nl/ws/files/96843022/Uitzonderingsverzoek_medeondertekend_.pdf
UR - http://www.scopus.com/inward/record.url?scp=85099755494&partnerID=8YFLogxK
U2 - https://doi.org/10.5604/01.3001.0014.5247
DO - https://doi.org/10.5604/01.3001.0014.5247
M3 - Phd-Thesis - Research and graduation internal
SN - 9789463614900
VL - 74
T3 - Postepy Higieny i Medycyny Doswiadczalnej
ER -