TY - JOUR
T1 - Childhood obesity in relation to poor asthma control and exacerbation: a meta-analysis
AU - Ahmadizar, Fariba
AU - Vijverberg, Susanne J. H.
AU - Arets, Hubertus G. M.
AU - de Boer, Anthonius
AU - Lang, Jason E.
AU - Kattan, Meyer
AU - Palmer, Colin N. A.
AU - Mukhopadhyay, Somnath
AU - Turner, Steve
AU - Maitland-van der Zee, Anke H.
PY - 2016
Y1 - 2016
N2 - To estimate the association between obesity and poor asthma control or risk of exacerbations in asthmatic children and adolescents, and to assess whether these associations are different by sex. A meta-analysis was performed on unpublished data from three North-European paediatric asthma cohorts (BREATHE, PACMAN (Pharmacogenetics of Asthma medication in Children: Medication with Antiinflammatory effects) and PAGES (Pediatric Asthma Gene Environment Study)) and 11 previously published studies (cross-sectional and longitudinal studies). Outcomes were poor asthma control (based on asthma symptoms) and exacerbations rates (asthma-related visits to the emergency department, asthma-related hospitalisations or use of oral corticosteroids). Overall pooled estimates of the odds ratios were obtained using fixed-or random-effects models. In a meta-analysis of 46070 asthmatic children and adolescents, obese children (body mass index. 95th percentile) compared with non-obese peers had a small but significant increased risk of asthma exacerbations (OR 1.17, 95% CI 1.03-1.34; I-2: 54.7%). However, there was no statistically significant association between obesity and poor asthma control (n= 4973, OR 1.23, 95% CI 0.99-1.53; I-2: 0.0%). After stratification for sex, the differences in odds ratios for girls and boys were similar, yet no longer statistically significant. In asthmatic children, obesity is associated with a minor increased risk of asthma exacerbations but not with poor asthma control. Sex does not appear to modify this risk
AB - To estimate the association between obesity and poor asthma control or risk of exacerbations in asthmatic children and adolescents, and to assess whether these associations are different by sex. A meta-analysis was performed on unpublished data from three North-European paediatric asthma cohorts (BREATHE, PACMAN (Pharmacogenetics of Asthma medication in Children: Medication with Antiinflammatory effects) and PAGES (Pediatric Asthma Gene Environment Study)) and 11 previously published studies (cross-sectional and longitudinal studies). Outcomes were poor asthma control (based on asthma symptoms) and exacerbations rates (asthma-related visits to the emergency department, asthma-related hospitalisations or use of oral corticosteroids). Overall pooled estimates of the odds ratios were obtained using fixed-or random-effects models. In a meta-analysis of 46070 asthmatic children and adolescents, obese children (body mass index. 95th percentile) compared with non-obese peers had a small but significant increased risk of asthma exacerbations (OR 1.17, 95% CI 1.03-1.34; I-2: 54.7%). However, there was no statistically significant association between obesity and poor asthma control (n= 4973, OR 1.23, 95% CI 0.99-1.53; I-2: 0.0%). After stratification for sex, the differences in odds ratios for girls and boys were similar, yet no longer statistically significant. In asthmatic children, obesity is associated with a minor increased risk of asthma exacerbations but not with poor asthma control. Sex does not appear to modify this risk
U2 - https://doi.org/10.1183/13993003.00766-2016
DO - https://doi.org/10.1183/13993003.00766-2016
M3 - Article
C2 - 27587561
SN - 0903-1936
VL - 48
SP - 1063
EP - 1073
JO - European respiratory journal
JF - European respiratory journal
IS - 4
ER -