TY - JOUR
T1 - Prognostic value of baseline MRI features in patients treated with thermal ablation for hepatocellular carcinoma
AU - Öcal, Osman
AU - Schütte, Kerstin
AU - Malfertheiner, Peter
AU - Berg, Thomas
AU - Loewe, Christian
AU - Klümpen, Heinz Josef
AU - Zech, Christoph Johannes
AU - van Delden, Otto
AU - Ümütlü, Muzaffer Reha
AU - Deniz, Sinan
AU - Khaled, Najib Ben
AU - de Toni, Enrico Narciso
AU - Hoang, Thi Phuong Thao
AU - Seidensticker, Ricarda
AU - Aghdassi, Ali
AU - Pech, Maciej
AU - Ricke, Jens
AU - Seidensticker, Max
N1 - Funding Information: SORAMIC is an investigator-initiated trial sponsored by the University of Magdeburg. Financial support was granted by Sirtex Medical (Woburn, Massachusetts, USA) and Bayer Healthcare (Berlin, Germany). Osman Öcal, Max Seidensticker, Peter Malfertheiner, Jens Ricke: Conception and design of the study; Generation, collection, assembly, analysis and/or interpretation of data; Drafting or revision of the manuscript; Approval of the final version of the manuscript. Kerstin Schütte, Thomas Berg, Christian Loewe, Heinz Josef Klümpen, Christoph J. Zech, Otto van Delden, Muzaffer Reha Ümütlü, Sinan Deniz, Najib Ben Khaled, Enrico N. de Toni, Thi Phuong Thao Hoang, Ricarda Seidensticker, Ali Aghdassi, Bruno Sangro, Maciej Pech: Generation, collection, assembly, analysis and/or interpretation of data; Drafting or revision of the manuscript; Approval of the final version of the manuscript. Publisher Copyright: © 2023
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Purpose: To investigate prognostic value of baseline MRI features for time-to-recurrence (TTR) and local recurrence in patients with early hepatocellular carcinoma (HCC). Method: Baseline and follow-up images of 88 patients treated with thermal ablation followed by adjuvant sorafenib or matching placebo due to HCC within the phase II prospective randomized trial (SORAMIC) were included. Baseline MRI images were evaluated in terms of atypical enhancement (lack of wash-in or wash-out), lesion diameter, tumor capsule, peritumoral enhancement on arterial phase, intratumoral fat, irregular margin, satellite lesions, and peritumoral hypointensity on hepatobiliary phase. Prognostic value of these features for TTR and local recurrence were assessed with univariable and multivariable Cox proportional hazard models. Results: Recurrence at any location was diagnosed during follow-up in 30 patients, and the median TTR was 16.4 (95% CI, 15 – NA) months. The presence of more than one lesion (p = 0.028) and peritumoral hypointensity on hepatobiliary phase images (p = 0.012) at baseline were significantly associated with shorter TTR in univariable analysis. AFP > 15 mg/dL (p = 0.084), and history of cirrhosis (p = 0.099) were marginally non-significant. Peritumoral hypointensity on hepatobiliary phase images was the only significant risk factor for recurrence in multivariable analysis (p = 0.003). Local recurrence (adjacent to thermal scar) was diagnosed in eleven (8.3%) out of 132 lesions that underwent thermal ablation. The only significant risk factor for local recurrence was a lesion diameter larger than 3 cm (22.2% vs. 4.5%, p = 0.007). Conclusions: Peritumoral hypointensity on hepatobiliary phase can serve as imaging biomarker to identify increased recurrence risk in patients undergoing thermal ablation for early-stage HCC.
AB - Purpose: To investigate prognostic value of baseline MRI features for time-to-recurrence (TTR) and local recurrence in patients with early hepatocellular carcinoma (HCC). Method: Baseline and follow-up images of 88 patients treated with thermal ablation followed by adjuvant sorafenib or matching placebo due to HCC within the phase II prospective randomized trial (SORAMIC) were included. Baseline MRI images were evaluated in terms of atypical enhancement (lack of wash-in or wash-out), lesion diameter, tumor capsule, peritumoral enhancement on arterial phase, intratumoral fat, irregular margin, satellite lesions, and peritumoral hypointensity on hepatobiliary phase. Prognostic value of these features for TTR and local recurrence were assessed with univariable and multivariable Cox proportional hazard models. Results: Recurrence at any location was diagnosed during follow-up in 30 patients, and the median TTR was 16.4 (95% CI, 15 – NA) months. The presence of more than one lesion (p = 0.028) and peritumoral hypointensity on hepatobiliary phase images (p = 0.012) at baseline were significantly associated with shorter TTR in univariable analysis. AFP > 15 mg/dL (p = 0.084), and history of cirrhosis (p = 0.099) were marginally non-significant. Peritumoral hypointensity on hepatobiliary phase images was the only significant risk factor for recurrence in multivariable analysis (p = 0.003). Local recurrence (adjacent to thermal scar) was diagnosed in eleven (8.3%) out of 132 lesions that underwent thermal ablation. The only significant risk factor for local recurrence was a lesion diameter larger than 3 cm (22.2% vs. 4.5%, p = 0.007). Conclusions: Peritumoral hypointensity on hepatobiliary phase can serve as imaging biomarker to identify increased recurrence risk in patients undergoing thermal ablation for early-stage HCC.
KW - Gadoxetic acid
KW - Hepatocellular carcinoma
KW - Local ablation
KW - Peritumoral hypointensity
KW - Time-to-recurrence
UR - http://www.scopus.com/inward/record.url?scp=85174742929&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ejrad.2023.111120
DO - https://doi.org/10.1016/j.ejrad.2023.111120
M3 - Article
C2 - 37806190
SN - 0720-048X
VL - 168
JO - European Journal of Radiology
JF - European Journal of Radiology
M1 - 111120
ER -