TY - JOUR
T1 - C-type lectin receptors in the control of T helper cell differentiation
AU - Geijtenbeek, Teunis B. H.
AU - Gringhuis, Sonja I.
PY - 2016
Y1 - 2016
N2 - Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is important not only for antigen presentation, but also for the induction of appropriate adaptive immune responses via T helper (TH) cell differentiation. CLRs act either by themselves or in cooperation with other receptors, such as other CLRs, Toll-like receptors and interferon receptors, to induce signalling pathways that trigger specialized cytokine programmes for polarization of TH cell differentiation. In this Review, we discuss how triggering of the prototypical CLRs leads to distinct pathogen-tailored TH cell responses and how we can harness our expanding knowledge for vaccine design and the treatment of inflammatory and malignant diseases
AB - Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is important not only for antigen presentation, but also for the induction of appropriate adaptive immune responses via T helper (TH) cell differentiation. CLRs act either by themselves or in cooperation with other receptors, such as other CLRs, Toll-like receptors and interferon receptors, to induce signalling pathways that trigger specialized cytokine programmes for polarization of TH cell differentiation. In this Review, we discuss how triggering of the prototypical CLRs leads to distinct pathogen-tailored TH cell responses and how we can harness our expanding knowledge for vaccine design and the treatment of inflammatory and malignant diseases
U2 - https://doi.org/10.1038/nri.2016.55
DO - https://doi.org/10.1038/nri.2016.55
M3 - Review article
C2 - 27291962
SN - 1474-1733
VL - 16
SP - 433
EP - 448
JO - Nature Reviews. Immunology
JF - Nature Reviews. Immunology
IS - 7
ER -