TY - JOUR
T1 - Microglia in pediatric brain tumors
T2 - The missing link to successful immunotherapy
AU - du Chatinier, Aimée
AU - Velilla, Irene Querol
AU - Meel, Michaël Hananja
AU - Hoving, Eelco Wieger
AU - Hulleman, Esther
AU - Metselaar, Dennis Serge
N1 - Funding Information: This study was supported by the Koppie-Au Foundation ( www.koppie-au.nl ). Publisher Copyright: © 2023 The Author(s)
PY - 2023/11/21
Y1 - 2023/11/21
N2 - Brain tumors are the leading cause of cancer-related mortality in children. Despite the development of immunotherapeutic strategies for adult brain tumors, progress in pediatric neuro-oncology has been hindered by the complex and poorly understood nature of the brain's immune system during early development, a phase that is critical for the onset of many pediatric brain tumors. A defining characteristic of these tumors is the abundance of microglia, the resident immune cells of the central nervous system. In this review, we explore the concept of microglial diversity across brain regions and throughout development and discuss how their maturation stage may contribute to tumor growth in children. We also summarize the current knowledge on the roles of microglia in common pediatric brain tumor entities and provide examples of myeloid-based immunotherapeutic strategies. Our review underscores the importance of microglial plasticity in pediatric brain tumors and its significance for developing effective immunotherapeutic strategies.
AB - Brain tumors are the leading cause of cancer-related mortality in children. Despite the development of immunotherapeutic strategies for adult brain tumors, progress in pediatric neuro-oncology has been hindered by the complex and poorly understood nature of the brain's immune system during early development, a phase that is critical for the onset of many pediatric brain tumors. A defining characteristic of these tumors is the abundance of microglia, the resident immune cells of the central nervous system. In this review, we explore the concept of microglial diversity across brain regions and throughout development and discuss how their maturation stage may contribute to tumor growth in children. We also summarize the current knowledge on the roles of microglia in common pediatric brain tumor entities and provide examples of myeloid-based immunotherapeutic strategies. Our review underscores the importance of microglial plasticity in pediatric brain tumors and its significance for developing effective immunotherapeutic strategies.
UR - http://www.scopus.com/inward/record.url?scp=85176910799&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.xcrm.2023.101246
DO - https://doi.org/10.1016/j.xcrm.2023.101246
M3 - Review article
C2 - 37924816
SN - 2666-3791
VL - 4
JO - Cell Reports Medicine
JF - Cell Reports Medicine
IS - 11
M1 - 101246
ER -