Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1573-1580 |
| Number of pages | 8 |
| Journal | Social Psychiatry and Psychiatric Epidemiology |
| Volume | 58 |
| Issue number | 10 |
| Early online date | 2023 |
| DOIs | |
| Publication status | Published - Oct 2023 |
Keywords
- Childhood adversity
- Cognition
- Family history of psychosis
- First episode
- Polygenic risk score
- Psychosis
Access to Document
Other files and links
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
In: Social Psychiatry and Psychiatric Epidemiology, Vol. 58, No. 10, 10.2023, p. 1573-1580.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - The relationship between genetic liability, childhood maltreatment, and IQ
T2 - findings from the EU-GEI multicentric case–control study
AU - Sideli, Lucia
AU - Aas, Monica
AU - Quattrone, Diego
AU - la Barbera, Daniele
AU - la Cascia, Caterina
AU - Ferraro, Laura
AU - Alameda, Luis
AU - Velthorst, Eva
AU - Trotta, Giulia
AU - Tripoli, Giada
AU - Schimmenti, Adriano
AU - Fontana, Andrea
AU - Gayer-Anderson, Charlotte
AU - Stilo, Simona
AU - Seminerio, Fabio
AU - Sartorio, Crocettarachele
AU - Marrazzo, Giovanna
AU - Lasalvia, Antonio
AU - Tosato, Sarah
AU - Tarricone, Ilaria
AU - Berardi, Domenico
AU - D’Andrea, Giuseppe
AU - EU-GEI WP2 Group
AU - Amoretti, Silvia
AU - Andreu-Bernabeu, Álvaro
AU - Baudin, Grégoire
AU - Beards, Stephanie
AU - Bonetto, Chiara
AU - Bonora, Elena
AU - Cabrera, Bibiana
AU - Carracedo, Angel
AU - Charpeaud, Thomas
AU - Costas, Javier
AU - Cristofalo, Doriana
AU - Cuadrado, Pedro
AU - Durán-Cutilla, Manuel
AU - Ferchiou, Aziz
AU - Fraguas, David
AU - Franke, Nathalie
AU - Frijda, Flora
AU - Garcia-Portilla, Paz
AU - González Peñas, Javier
AU - Hubbard, Kathryn
AU - Jamain, Stéphane
AU - Jiménez-López, Estela
AU - Leboyer, Marion
AU - Llorente, Cloe
AU - López Montoya, Gonzalo
AU - Termorshuizen, Fabian
AU - van Dam, Daniella
AU - de Haan, Lieuwe
N1 - Funding Information: The European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) WP2 Group members includes: Amoretti, Silvia, PhD, Barcelona Clinic Schizophrenia Unit Funding Information: We are grateful to the EU-GEI study participants for their essential contribution to this project. The EU-GEI Study is funded by grant agreement HEALTH-F2-2010–241909 (Project EU-GEI) from the European Community’s Seventh Framework Programme, and Grant 2012/0417–0 from the São Paulo Research Foundation. B.P.F. Rutten is funded by a VIDI award (no. 91.718.336) from the Netherlands Scientific Organization. H. L. Fisher, C. Gayer-Anderson, and C. Morgan are supported by the Economic and Social Research Council (ESRC) Centre for Society and Mental Health at King’s College London [ES/S012567/1]. D. Quattrone is supported by the Medical Research Council Clinical Academic Research Partnership [MR/W030608/1]. M. Aas is supported by an MRC fellowship (#MR/WO27720/1). C. Arango has received support from the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (ISCIII), co-financed by the European Union, ERDF Funds from the European Commission, “A way of making Europe”, financed by the European Union—NextGenerationEU (PMP21/00051, PI19/01024), CIBERSAM, Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds, European Union Seventh Framework Program, European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking: Project PRISM-2 (Grant agreement No.101034377), Project AIMS-2-TRIALS (Grant agreement No 777394), Horizon Europe, the National Institute of Mental Health of the National Institutes of Health under Award Number 1U01MH124639-01 (Project ProNET) and Award Number 5P50MH115846-03 (Project FEP-CAUSAL), Fundación Familia Alonso, and Fundación Alicia Koplowitz. The views expressed are those of the authors and not necessarily those of the ESRC or King’s College London. Publisher Copyright: © 2023, The Author(s).
PY - 2023/10
Y1 - 2023/10
N2 - This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.
AB - This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.
KW - Childhood adversity
KW - Cognition
KW - Family history of psychosis
KW - First episode
KW - Polygenic risk score
KW - Psychosis
UR - http://www.scopus.com/inward/record.url?scp=85162996860&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00127-023-02513-0
DO - https://doi.org/10.1007/s00127-023-02513-0
M3 - Article
C2 - 37335320
SN - 0933-7954
VL - 58
SP - 1573
EP - 1580
JO - Social Psychiatry and Psychiatric Epidemiology
JF - Social Psychiatry and Psychiatric Epidemiology
IS - 10
ER -