TY - JOUR
T1 - Valvulogenesis of a living, innervated pulmonary root induced by an acellular scaffold
AU - Yacoub, Magdi H.
AU - Tseng, Yuan-Tsan
AU - Kluin, Jolanda
AU - Vis, Annemijn
AU - Stock, Ulrich
AU - Smail, Hassiba
AU - Sarathchandra, Padmini
AU - Aikawa, Elena
AU - el-Nashar, Hussam
AU - Chester, Adrian H.
AU - Shehata, Nairouz
AU - Nagy, Mohamed
AU - el-sawy, Amr
AU - Li, Wei
AU - Burriesci, Gaetano
AU - Salmonsmith, Jacob
AU - Romeih, Soha
AU - Latif, Najma
N1 - Funding Information: The study was supported by Heart Biotech and the Magdi Yacoub Institute. Publisher Copyright: © 2023, Springer Nature Limited.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and quality of life. This has stimulated extensive attempts at tissue engineering “living” heart valves. These attempts utilised combinations of allogeneic/ autologous cells and biological scaffolds with practical, regulatory, and ethical issues. In situ regeneration depends on scaffolds that attract, house and instruct cells and promote connective tissue formation. We describe a surgical, tissue-engineered, anatomically precise, novel off-the-shelf, acellular, synthetic scaffold inducing a rapid process of morphogenesis involving relevant cell types, extracellular matrix, regulatory elements including nerves and humoral components. This process relies on specific material characteristics, design and “morphodynamism”.
AB - Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and quality of life. This has stimulated extensive attempts at tissue engineering “living” heart valves. These attempts utilised combinations of allogeneic/ autologous cells and biological scaffolds with practical, regulatory, and ethical issues. In situ regeneration depends on scaffolds that attract, house and instruct cells and promote connective tissue formation. We describe a surgical, tissue-engineered, anatomically precise, novel off-the-shelf, acellular, synthetic scaffold inducing a rapid process of morphogenesis involving relevant cell types, extracellular matrix, regulatory elements including nerves and humoral components. This process relies on specific material characteristics, design and “morphodynamism”.
UR - http://www.scopus.com/inward/record.url?scp=85173526072&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s42003-023-05383-z
DO - https://doi.org/10.1038/s42003-023-05383-z
M3 - Article
C2 - 37805576
SN - 2399-3642
VL - 6
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 1017
ER -