TY - JOUR
T1 - Association between BNT162b2 vaccination and health-related quality of life up to 18 months post-SARS-CoV-2 infection in Israel
AU - Kuodi, Paul
AU - Gorelik, Yanay
AU - Zayyad, Hiba
AU - Wertheim, Ofir
AU - Beiruti Wiegler, Karine
AU - Abu Jabal, Kamal
AU - Dror, Amiel A.
AU - Elsinga, Jelte
AU - Nazzal, Saleh
AU - Glikman, Daniel
AU - Edelstein, Michael
N1 - Funding Information: This study was partly funded from a donation from the Harvey Goodstein Charitable Foundation. The funder had no role in the writing of the manuscript or the decision to submit for publications. The funding enabled to fund software licenses for statistical software, SMS packages used for sending invitations to participants, and will fund the open access publication fees. The authors were not paid to write this article by a pharmaceutical company or any other agency. The authors were not precluded from accessing data in the study and accept responsibility to submit for publication. Funding Information: We wish to thank Yehudit Hakmon, Eliran Levi, Zion Levi, Nissim Neeman (Ziv Medical Centre), Mark Lifishitz, and Shelly Shalem (Galilee Medical Centre) for their technical help and support in disseminating the questionnaire. Publisher Copyright: © 2023, Springer Nature Limited.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - We determined whether COVID-19 vaccination was associated with Quality of Life (QoL) changes among individuals previously infected with SARS-CoV-2 in Israel. Using a validated questionnaire, we collected information about socio-demographics, SARS-CoV-2 infection, COVID-19 vaccination and QoL (using the EQ-5D-5L tool) 3–18 months post-infection among adults tested for SARS-CoV-2 by polymerase chain reaction in Northern Israel between March 2020–June 2022. We compared post-COVID QoL between those vaccinated against COVID-19 at the time of infection and those not, using an adjusted linear regression model, stratified by time elapsed since infection. Of 951 participants, mean EQ-5D Utility Index (EQ-5D UI) was 0.82 (SD = 0.26) and 0.83 (SD = 0.25) among the 227 double and 250 triple vaccinated respectively, compared to 0.76 (SD = 0.33) among those who received 0 dose (n = 243). The size of the effect of vaccination was small (Cohen’s d = 0.2). In the adjusted model, previously infected individuals vaccinated with two or more doses reported a QoL score post- infection 0.05 points higher (CI = 0.01–0.10, p = 0.02) compared with those unvaccinated when infected. No association between vaccination and QoL was detected beyond 12 months post-infection. Vaccination with two or more doses of COVID19 vaccine, or at least the BNT162b2 vaccine, may modestly mitigate QoL losses associated with post-acute COVID-19 symptoms, at least in the first 12 months post-infection.
AB - We determined whether COVID-19 vaccination was associated with Quality of Life (QoL) changes among individuals previously infected with SARS-CoV-2 in Israel. Using a validated questionnaire, we collected information about socio-demographics, SARS-CoV-2 infection, COVID-19 vaccination and QoL (using the EQ-5D-5L tool) 3–18 months post-infection among adults tested for SARS-CoV-2 by polymerase chain reaction in Northern Israel between March 2020–June 2022. We compared post-COVID QoL between those vaccinated against COVID-19 at the time of infection and those not, using an adjusted linear regression model, stratified by time elapsed since infection. Of 951 participants, mean EQ-5D Utility Index (EQ-5D UI) was 0.82 (SD = 0.26) and 0.83 (SD = 0.25) among the 227 double and 250 triple vaccinated respectively, compared to 0.76 (SD = 0.33) among those who received 0 dose (n = 243). The size of the effect of vaccination was small (Cohen’s d = 0.2). In the adjusted model, previously infected individuals vaccinated with two or more doses reported a QoL score post- infection 0.05 points higher (CI = 0.01–0.10, p = 0.02) compared with those unvaccinated when infected. No association between vaccination and QoL was detected beyond 12 months post-infection. Vaccination with two or more doses of COVID19 vaccine, or at least the BNT162b2 vaccine, may modestly mitigate QoL losses associated with post-acute COVID-19 symptoms, at least in the first 12 months post-infection.
UR - http://www.scopus.com/inward/record.url?scp=85171842000&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41598-023-43058-1
DO - https://doi.org/10.1038/s41598-023-43058-1
M3 - Article
C2 - 37737268
SN - 2045-2322
VL - 13
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 15801
ER -