TY - JOUR
T1 - Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study
AU - Hegen, Harald
AU - Berek, Klaus
AU - Cavalla, Paola
AU - Christiansen, Mikael
AU - Emeršič, Andreja
AU - di Filippo, Massimiliano
AU - Gaetani, Lorenzo
AU - Hassler, Michaela
AU - Leurs, Cyra
AU - Milosavljevic, Dejan
AU - van Pesch, Vincent
AU - Petersen, Thor
AU - Presslauer, Stefan
AU - Rosenstein, Igal
AU - Rot, Uroš
AU - Schnabl, Christine
AU - Teunissen, Charlotte
AU - Vecchio, Domizia
AU - Vercellino, Marco
AU - Deisenhammer, Florian
N1 - Funding Information: The authors declare no financial support was received for the research, authorship, and/or publication of this article. Publisher Copyright: Copyright © 2023 Hegen, Berek, Cavalla, Christiansen, Emeršič, Di Filippo, Gaetani, Hassler, Leurs, Milosavljevic, van Pesch, Petersen, Presslauer, Rosenstein, Rot, Schnabl, Teunissen, Vecchio, Vercellino and Deisenhammer.
PY - 2023
Y1 - 2023
N2 - Background: Kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS). Objective: To investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB). Methods: Patients with PPMS were recruited through 11 MS centres across 7 countries. κ-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation. Results: A total of 174 patients (mean age of 52±11 years, 51% males) were included. κ-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients. Conclusion: κ-FLC index shows similar diagnostic sensitivity than OCB in PPMS.
AB - Background: Kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS). Objective: To investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB). Methods: Patients with PPMS were recruited through 11 MS centres across 7 countries. κ-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation. Results: A total of 174 patients (mean age of 52±11 years, 51% males) were included. κ-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients. Conclusion: κ-FLC index shows similar diagnostic sensitivity than OCB in PPMS.
KW - cerebrospinal fluid
KW - diagnosis
KW - kappa free light chain
KW - multiple sclerosis
KW - primary progressive
KW - sensitivity
UR - http://www.scopus.com/inward/record.url?scp=85181201168&partnerID=8YFLogxK
U2 - https://doi.org/10.3389/fimmu.2023.1327947
DO - https://doi.org/10.3389/fimmu.2023.1327947
M3 - Article
C2 - 38169789
SN - 1664-3224
VL - 14
JO - Frontiers in immunology
JF - Frontiers in immunology
M1 - 1327947
ER -