TY - JOUR
T1 - Discontinuation of intravenous oxytocin in the active phase of induced labour
AU - Boie, Sidsel
AU - Glavind, Julie
AU - Velu, Adeline V.
AU - Mol, Ben Willem J.
AU - Uldbjerg, Niels
AU - de Graaf, Irene
AU - Thornton, Jim G.
AU - Bor, Pinar
AU - Bakker, Jannet J. H.
PY - 2018
Y1 - 2018
N2 - Background In most Western countries, obstetricians and midwives induce labour in about 25% of pregnant women. Oxytocin is an effective drug for this purpose, but associated with serious adverse effects of which uterine tachysystole, fetal distress and the need for immediate delivery are the most common. Various administration regimens such as reduced or pulsatile dosing have been suggested to minimise these. Discontinuation in the active phase of labour, i.e. when contractions are well-established and the cervix is dilated at least 5 cm is another method which may reduce adverse effects. Objectives To assess whether birth outcomes can be improved by discontinuation of intravenous (IV) oxytocin, initiated in the latent phase of induced labour, once active phase of labour is established. Search methods We searched Cochrane Pregnancy and Childbirth's Trials Register (31 January 2018), Scopus, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform (ICTRP) (23 January 2018) together with reference checking, citation searching, and contact with study authors to identify additional studies. Selection criteria Randomised controlled trials (RCTs) comparing discontinued IV with continuous IV oxytocin in the active phase of induced labour. No exclusion criteria were applied in terms of parity, maternal age, ethnicity, co-morbidity status, labour setting, gestational age, and prior caesarean delivery. Studies comparing different dosage regimens are outside the scope of this review. Data collection and analysis We used standard Cochrane methods.
AB - Background In most Western countries, obstetricians and midwives induce labour in about 25% of pregnant women. Oxytocin is an effective drug for this purpose, but associated with serious adverse effects of which uterine tachysystole, fetal distress and the need for immediate delivery are the most common. Various administration regimens such as reduced or pulsatile dosing have been suggested to minimise these. Discontinuation in the active phase of labour, i.e. when contractions are well-established and the cervix is dilated at least 5 cm is another method which may reduce adverse effects. Objectives To assess whether birth outcomes can be improved by discontinuation of intravenous (IV) oxytocin, initiated in the latent phase of induced labour, once active phase of labour is established. Search methods We searched Cochrane Pregnancy and Childbirth's Trials Register (31 January 2018), Scopus, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform (ICTRP) (23 January 2018) together with reference checking, citation searching, and contact with study authors to identify additional studies. Selection criteria Randomised controlled trials (RCTs) comparing discontinued IV with continuous IV oxytocin in the active phase of induced labour. No exclusion criteria were applied in terms of parity, maternal age, ethnicity, co-morbidity status, labour setting, gestational age, and prior caesarean delivery. Studies comparing different dosage regimens are outside the scope of this review. Data collection and analysis We used standard Cochrane methods.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85133967445&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30125998
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055074203&origin=inward
U2 - https://doi.org/10.1002/14651858.CD012274.PUB2
DO - https://doi.org/10.1002/14651858.CD012274.PUB2
M3 - Comment/Letter to the editor
C2 - 30125998
SN - 1465-1858
VL - 2018
SP - CD012274
JO - Cochrane Database of Systematic Reviews
JF - Cochrane Database of Systematic Reviews
IS - 8
M1 - CD012274
ER -