TY - JOUR
T1 - A cross-country comparison of pregnant women's decision-making and perspectives when opting for non-invasive prenatal testing in the Netherlands and Belgium
AU - Lannoo, Lore
AU - van der Meij, Karuna R. M.
AU - Bekker, Mireille N.
AU - de Catte, Luc
AU - Deckers, Sarah
AU - Devriendt, Koenraad
AU - Roggen, Nele
AU - Galjaard, Robert-Jan H.
AU - Gitsels-van der Wal, Janneke
AU - Macville, Merryn V. E.
AU - Martin, Linda
AU - Sistermans, Erik A.
AU - van Calsteren, Kristel
AU - van Keirsbilck, Joachim
AU - Crombag, Neeltje
AU - Henneman, Lidewij
N1 - Funding Information: The authors would like to acknowledge all pregnant women for completing the questionnaires and to thank all prenatal counselors who made this study possible. Members of the Belgian and Dutch NIPT Consortium are thanked for fruitful discussions. This work was supported by Clinical Research Funding (KOOR-Funding University Hospital Leuven for Lore Lannoo/Kristel Van Calsteren). Grant from the Netherlands Organisation for Health Research and Development (ZonMw) grant no 543002001 for the Dutch TRIDENT-2 study. Funding Information: The authors would like to acknowledge all pregnant women for completing the questionnaires and to thank all prenatal counselors who made this study possible. Members of the Belgian and Dutch NIPT Consortium are thanked for fruitful discussions. This work was supported by Clinical Research Funding (KOOR‐Funding University Hospital Leuven for Lore Lannoo/Kristel Van Calsteren). Grant from the Netherlands Organisation for Health Research and Development (ZonMw) grant no 543002001 for the Dutch TRIDENT‐2 study. Publisher Copyright: © 2023 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd.
PY - 2023/3
Y1 - 2023/3
N2 - Background: The Netherlands and Belgium have been among the first countries to offer non-invasive prenatal testing (NIPT) as a first-tier screening test. Despite similarities, differences exist in counseling modalities and test uptake. This study explored decision-making and perspectives of pregnant women who opted for NIPT in both countries. Methods: A questionnaire study was performed among pregnant women in the Netherlands (NL) (n = 587) and Belgium (BE) (n = 444) opting for NIPT, including measures on informed choice, personal and societal perspectives on trisomy 21, 18 and 13 and pregnancy termination. Results: Differences between Dutch and Belgian women were shown in the level of informed choice (NL: 83% vs. BE: 59%, p < 0.001), intention to terminate the pregnancy in case of confirmed trisomy 21 (NL: 51% vs. BE: 62%, p = 0.003) and trisomy 13/18 (NL: 80% vs. BE: 73%, p = 0.020). More Belgian women considered trisomy 21 a severe condition (NL: 64% vs. BE: 81%, p < 0.001). Belgian women more frequently indicated that they believed parents are judged for having a child with trisomy 21 (BE: 42% vs. NL: 16%, p < 0.001) and were less positive about quality of care and support for children with trisomy 21 (BE: 23% vs. NL: 62%, p < 0.001). Conclusion: Differences in women's decision-making regarding NIPT and the conditions screened for may be influenced by counseling aspects and country-specific societal and cultural contexts.
AB - Background: The Netherlands and Belgium have been among the first countries to offer non-invasive prenatal testing (NIPT) as a first-tier screening test. Despite similarities, differences exist in counseling modalities and test uptake. This study explored decision-making and perspectives of pregnant women who opted for NIPT in both countries. Methods: A questionnaire study was performed among pregnant women in the Netherlands (NL) (n = 587) and Belgium (BE) (n = 444) opting for NIPT, including measures on informed choice, personal and societal perspectives on trisomy 21, 18 and 13 and pregnancy termination. Results: Differences between Dutch and Belgian women were shown in the level of informed choice (NL: 83% vs. BE: 59%, p < 0.001), intention to terminate the pregnancy in case of confirmed trisomy 21 (NL: 51% vs. BE: 62%, p = 0.003) and trisomy 13/18 (NL: 80% vs. BE: 73%, p = 0.020). More Belgian women considered trisomy 21 a severe condition (NL: 64% vs. BE: 81%, p < 0.001). Belgian women more frequently indicated that they believed parents are judged for having a child with trisomy 21 (BE: 42% vs. NL: 16%, p < 0.001) and were less positive about quality of care and support for children with trisomy 21 (BE: 23% vs. NL: 62%, p < 0.001). Conclusion: Differences in women's decision-making regarding NIPT and the conditions screened for may be influenced by counseling aspects and country-specific societal and cultural contexts.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85148433562&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36740754
U2 - https://doi.org/10.1002/pd.6329
DO - https://doi.org/10.1002/pd.6329
M3 - Article
C2 - 36740754
SN - 0197-3851
VL - 43
SP - 294
EP - 303
JO - Prenatal diagnosis
JF - Prenatal diagnosis
IS - 3
ER -