Novel biomarkers to guide therapy in chronic inflammatory diseases

I.L. Hageman

Novel biomarkers to guide therapy in chronic inflammatory diseases

Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

Abstract

In this thesis, we focused on the role of the epigenetic modifications in Inflammatory Bowel Disease (IBD) and other immune mediated diseases such as rheumatoid arthritis. In particular, we elaborated on aberrant DNA methylation and investigated its potential to predict therapy response to biological treatment. Furthermore, we explored other novel biomarkers to biological response with microbial signatures and single cell transcriptomics in IBD.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Amsterdam
Supervisors/Advisors	de Jonge, Wouter, Supervisor D' Haens, Geert, Supervisor Hakvoort, Theo, Co-supervisor Henneman, Peter, Co-supervisor
Award date	20 Dec 2023
Print ISBNs	9789493278660
Publication status	Published - 2023

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abstract = "In this thesis, we focused on the role of the epigenetic modifications in Inflammatory Bowel Disease (IBD) and other immune mediated diseases such as rheumatoid arthritis. In particular, we elaborated on aberrant DNA methylation and investigated its potential to predict therapy response to biological treatment. Furthermore, we explored other novel biomarkers to biological response with microbial signatures and single cell transcriptomics in IBD.",

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AB - In this thesis, we focused on the role of the epigenetic modifications in Inflammatory Bowel Disease (IBD) and other immune mediated diseases such as rheumatoid arthritis. In particular, we elaborated on aberrant DNA methylation and investigated its potential to predict therapy response to biological treatment. Furthermore, we explored other novel biomarkers to biological response with microbial signatures and single cell transcriptomics in IBD.

UR - https://pure.uva.nl/ws/files/146963997/Licentieovereenkomst_medeondertekend_.pdf

M3 - Phd-Thesis - Research and graduation internal

SN - 9789493278660

ER -

Novel biomarkers to guide therapy in chronic inflammatory diseases

Abstract

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