TY - JOUR
T1 - Evidence Accumulates
T2 - Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease
AU - Waldron, Christina
AU - Zafar, Mohammad A.
AU - Ziganshin, Bulat A.
AU - Weininger, Gabe
AU - Grewal, Nimrat
AU - Elefteriades, John A.
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Ascending thoracic aortic aneurysms may be fatal upon rupture or dissection and remain a leading cause of death in the developed world. Understanding the pathophysiology of the development of ascending thoracic aortic aneurysms may help reduce the morbidity and mortality of this disease. In this review, we will discuss our current understanding of the protective relationship between ascending thoracic aortic aneurysms and the development of atherosclerosis, including decreased carotid intima–media thickness, low-density lipoprotein levels, coronary and aortic calcification, and incidence of myocardial infarction. We also propose several possible mechanisms driving this relationship, including matrix metalloproteinase proteins and transforming growth factor- (Formula presented.).
AB - Ascending thoracic aortic aneurysms may be fatal upon rupture or dissection and remain a leading cause of death in the developed world. Understanding the pathophysiology of the development of ascending thoracic aortic aneurysms may help reduce the morbidity and mortality of this disease. In this review, we will discuss our current understanding of the protective relationship between ascending thoracic aortic aneurysms and the development of atherosclerosis, including decreased carotid intima–media thickness, low-density lipoprotein levels, coronary and aortic calcification, and incidence of myocardial infarction. We also propose several possible mechanisms driving this relationship, including matrix metalloproteinase proteins and transforming growth factor- (Formula presented.).
KW - abdominal aneurysm
KW - atherosclerosis
KW - intimal medial thickness
KW - myocardial infarction
KW - thoracic aortic aneurysm
KW - vascular calcification
UR - http://www.scopus.com/inward/record.url?scp=85176567604&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/ijms242115640
DO - https://doi.org/10.3390/ijms242115640
M3 - Review article
C2 - 37958625
SN - 1661-6596
VL - 24
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 21
M1 - 15640
ER -