TY - JOUR
T1 - 7T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer's disease
AU - Kenkhuis, Boyd
AU - Jonkman, Laura E.
AU - Bulk, Marjolein
AU - Buijs, Mathijs
AU - Boon, Baayla D. C.
AU - Bouwman, Femke H.
AU - Geurts, Jeroen J. G.
AU - van de Berg, Wilma D. J.
AU - van der Weerd, Louise
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Using 7T T2⁎-weighted imaging, we scanned post-mortem hemispheres of Alzheimer patients and age-matched controls to describe the patterns of appearance of cortical lamination on T2*-weighted MRI in the medial temporal lobe and to assess the changes in Alzheimer patients versus controls. While controls showed a hypointense line of Baillarger in the majority of the cases, appearance of cortical lamination varied to a greater extent in the Alzheimer patients. Severely distorted cortical lamination was also observed in advanced stage Alzheimer patients and presented itself as a broad hypointense inhomogeneous band, covering a large part of the cortical width. Histology indicated that the changes in the appearance of visible cortical lamination were not only associated with myelin changes, but also with diffuse cortical iron alterations and depositions. Therefore, imaging cortical lamination alterations in Alzheimer patients using T2*-weighted MRI might provide new information on involved neuroanatomical structures in an advanced neurodegenerative stage.
AB - Using 7T T2⁎-weighted imaging, we scanned post-mortem hemispheres of Alzheimer patients and age-matched controls to describe the patterns of appearance of cortical lamination on T2*-weighted MRI in the medial temporal lobe and to assess the changes in Alzheimer patients versus controls. While controls showed a hypointense line of Baillarger in the majority of the cases, appearance of cortical lamination varied to a greater extent in the Alzheimer patients. Severely distorted cortical lamination was also observed in advanced stage Alzheimer patients and presented itself as a broad hypointense inhomogeneous band, covering a large part of the cortical width. Histology indicated that the changes in the appearance of visible cortical lamination were not only associated with myelin changes, but also with diffuse cortical iron alterations and depositions. Therefore, imaging cortical lamination alterations in Alzheimer patients using T2*-weighted MRI might provide new information on involved neuroanatomical structures in an advanced neurodegenerative stage.
KW - Alzheimer's disease
KW - Cortical lamination
KW - Iron
KW - Magnetic resonance imaging
KW - Myelin
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059807327&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30642758
U2 - https://doi.org/10.1016/j.nicl.2019.101665
DO - https://doi.org/10.1016/j.nicl.2019.101665
M3 - Article
C2 - 30642758
SN - 2213-1582
VL - 21
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 101665
ER -