TY - JOUR
T1 - Diagnosing lanolin contact allergy with lanolin alcohol and Amerchol L101
AU - Knijp, Jannet
AU - Bruynzeel, Derk P.
AU - Rustemeyer, Thomas
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Background: The prevalence of lanolin contact allergy in dermatitis patients varies from 1.2% to 6.9%. Different lanolin derivatives are used in patch testing. Objectives: To determine which combination of lanolin derivatives is most effective in patch testing for the diagnosis of lanolin contact allergy. Methods: A retrospective analysis of patients patch tested between 2016 and 2017 was performed. Patients were eligible if they had been tested with lanolin alcohol 30% pet., Amerchol L101 50% pet., and a supplementary series containing other lanolin derivatives. Lanolin alcohol and Amerchol L101 were tested in duplicate. Results: Of 594 patients, 28.6% (95% confidence interval [CI]: 25.1%-32.3%) had a positive patch test reaction to at least one lanolin derivative. Reactions to lanolin alcohol (14.7%, 95%CI: 11.3%-18.2%) and Amerchol L101 (15.0%, 95%CI: 11.5%-18.5%) were common in the routinely tested series. Reactions to other test preparations were significantly less frequent (P < 0.05). The addition of Amerchol L101 to lanolin alcohol significantly increased the number of positive cases (odds ratio 1.79, P < 0.001). Conclusions: The combination of lanolin alcohol and Amerchol L101 is effective in patch testing for the diagnosis of lanolin contact allergy. Routinely testing with other lanolin derivatives may not be worthwhile, as it detects only a few additional patients.
AB - Background: The prevalence of lanolin contact allergy in dermatitis patients varies from 1.2% to 6.9%. Different lanolin derivatives are used in patch testing. Objectives: To determine which combination of lanolin derivatives is most effective in patch testing for the diagnosis of lanolin contact allergy. Methods: A retrospective analysis of patients patch tested between 2016 and 2017 was performed. Patients were eligible if they had been tested with lanolin alcohol 30% pet., Amerchol L101 50% pet., and a supplementary series containing other lanolin derivatives. Lanolin alcohol and Amerchol L101 were tested in duplicate. Results: Of 594 patients, 28.6% (95% confidence interval [CI]: 25.1%-32.3%) had a positive patch test reaction to at least one lanolin derivative. Reactions to lanolin alcohol (14.7%, 95%CI: 11.3%-18.2%) and Amerchol L101 (15.0%, 95%CI: 11.5%-18.5%) were common in the routinely tested series. Reactions to other test preparations were significantly less frequent (P < 0.05). The addition of Amerchol L101 to lanolin alcohol significantly increased the number of positive cases (odds ratio 1.79, P < 0.001). Conclusions: The combination of lanolin alcohol and Amerchol L101 is effective in patch testing for the diagnosis of lanolin contact allergy. Routinely testing with other lanolin derivatives may not be worthwhile, as it detects only a few additional patients.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063108933&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30624788
U2 - https://doi.org/10.1111/cod.13210
DO - https://doi.org/10.1111/cod.13210
M3 - Article
C2 - 30624788
SN - 0105-1873
VL - 80
SP - 298
EP - 303
JO - Contact dermatitis
JF - Contact dermatitis
IS - 5
ER -