Abstract
Original language | English |
---|---|
Pages (from-to) | 3427-3438 |
Number of pages | 12 |
Journal | Quality of life research |
Volume | 32 |
Issue number | 12 |
Early online date | 2023 |
DOIs | |
Publication status | Published - Dec 2023 |
Externally published | Yes |
Keywords
- Alcohol
- Direct-acting antivirals
- HCV cure
- Health-related quality of life
- Hepatitis C virus
- Vulnerable population
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In: Quality of life research, Vol. 32, No. 12, 12.2023, p. 3427-3438.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Impaired health-related quality of life in the HCV cure era
T2 - who is concerned? (ANRS CO22 HEPATHER French cohort)
AU - Carrieri, Patrizia
AU - Bourlière, Marc
AU - di Beo, Vincent
AU - Lusivika-Nzinga, Clovis
AU - Ramier, Clémence
AU - Antwerpes, Saskia
AU - Protopopescu, Camelia
AU - Lacombe, Jean-Marc
AU - Pol, Stanislas
AU - Fontaine, H. lène
AU - Mourad, Abbas
AU - Carrat, Fabrice
AU - Duracinsky, Martin
AU - Marcellin, Fabienne
N1 - Funding Information: We thank all of the members of the ANRS CO22 HEPATHER cohort Study Group, all the patients who participated in the HRQoL study, and all the healthcare staff involved in patient follow-up in each centre. Our thanks also to the INSERM-ANRS MIE for sponsoring, funding and supervising the ANRS CO22 HEPATHER cohort in collaboration with the French Association for the Study of the Liver (Association Française pour l’Etude du Foie: AFEF). Finally, we thank Jude Sweeney (Milan, Italy) for the English revision and copyediting of our manuscript. The ANRS/AFEF HEPATHER Study Group: Investigators Laurent Alric, Delphine Bonnet, Océane Camou (CHU Rangueil, Toulouse, France), Fabien Zoulim, Marianne Maynard, François Bailly, Bénédicte Poumaroux, Miroslava Subic (Hospices Civils de Lyon, Lyon, France), François Raffi, Eric Billaud, David Boutoille, Maeva Lefebvre, Elisabeth André-Garnier (Hôpital Hôtel-Dieu, Nantes, France), Paul Cales, Isabelle Hubert, Clémence Canivet, Françoise Lunel, Jérôme Boursier (CHU Angers, Angers, France), Tarik Asselah, Nathalie Boyer, Nathalie Giuily, Corinne Castelnau, Giovanna Scoazec (Hôpital Beaujon, Clichy, France), Stanislas Pol, Hélène Fontaine, Lucia Parlati, Emilie Rousseaud, Anaïs Vallet-Pichard, Philippe Sogni (Hôpital Cochin, Paris, France), Victor de Ledinghen, Juliette Foucher, Jean-Baptiste Hiriart, Paul Hermabessière, Marie Irlès-Depé (Hôpital Haut-Lévêque, Pessac, Bordeaux, France), Marc Bourlière, Si Nafa Si Ahmed, Valérie Oules, Rania Kibeche (Hôpital Saint Joseph, Marseille, France), Albert Tran, Rodolphe Anty, Eve Gelsi, Régine Truchi (CHU de Nice, Nice, France), Dominique Thabut, Saloua Hammeche, Joseph Moussali (Hôpital de la Pitié Salptétrière, Paris, France), Xavier Causse, Barbara De Dieuleveult, Brahim Ouarani, Damien Labarrière, Magali Jeulin (CHR La Source, Orléans, France), Nathalie Ganne, Véronique Grando-Lemaire, Pierre Nahon, Séverine Brulé, Lucie Del Pozo (Avicenne, Bobigny, France), Caroline Jezequel, Audrey Brener (CHU Rennes, Rennes, France), François Habersetzer, Thomas F. Baumert, Lawrence Serfaty, Pauline Simo-Noumbissie, Alexandre Bolle (Hôpitaux Universitaires de Strasbourg, Strasbourg, France), Jean-Pierre Bronowicki, Mouni Bensenane-Oussalah, Vincent Haghnejad, Sébastien Daude, Sarah Hadj-Rhouma (CHU de Nancy, Nancy, France), Georges-Philippe Pageaux, Dominique Larrey, Magda Meszaros (Hôpital Saint Eloi, Montpellier, France), Sophie Metivier, Christophe Bureau, Thibault Morales, Jean Marie Peron, Hélène Larrue (CHU Rangueil, Toulouse, France), Thomas Decaens, Marie-Noelle Hilleret, Charlotte Costentin, Bleuenn Brusset, Agnès Bonadona (CHU de Grenoble, Grenoble, France), Ghassan Riachi, Odile Goria, Fatima Paris, Hélène Montialoux (CHU Charles Nicolle, Rouen, France), Vincent Leroy, Giuliana Amaddeo, Anne Varaut, Mélanie Simoes, Rachida Amzal, Slim Fourati (Hôpital Henri Mondor, Créteil, France), Olivier Chazouillières, Tony Andreani, Bénédicte Angoulevant, Azeline Chevance (Hôpital Saint-Antoine, Paris, France), Jean-Charles Duclos Vallée, Audrey Coilly, Rodolphe Sobesky, Alina Pascale (Hôpital Paul Brousse, Villejuif, France), Benjamin Buchard, Armand Abergel, Maud Reymond, Chanteranne Brigitte, Léon Muti (Hôpital Estaing, Clermont-Ferrand, France), Vincent Di Martino (Hôpital Jean-Minjoz, Besançon, France), Claire Geist, Guillaume Conroy, Raphaëlle Riffault (Centre Hospitalier Régional, Metz, France), Isabelle Rosa, Camille Barrault, Laurent Costes, Anne Wampach (Centre Hospitalier Intercommunal, Créteil, France), Véronique Loustaud-Ratti, Paul Carrier, Maryline Debette-Gratien, (CHU Limoges, Limoges, France), Christine Silvain, Valentin Rolle, Valérie Roumy, Astrid Guyot d’Asnières de Salins (Hôpital de la Milétrie, Poitiers, France), Philippe Mathurin, Guillaume Lassailly, Elise Lemaitre, Valérie Canva, Sébastien Dharancy, Alexandre Louvet (CHRU Claude Huriez, Lille, France), Anne Minello, Marianne Latournerie, Thomas Mouillot Léa Lerosey, Théophile Gerster (Dijon University Hospital, Dijon, France), Dominique Roulot, Zahia Ben Abdesselam, (Hôpital Avicenne, Bobigny, France), Louis D’Alteroche, Coralie Fleurent, Charlotte Nicolas, Laure Elkrief, Anaïs Jaillais (CHU Trousseau, 37044 Tours, France), Denis Ouzan (Institut Arnault Tzank, Saint-Laurent-du-Var, France), Jérôme Gournay, Caroline Chevalier, Isabelle Archambeaud (CHU de Nantes, Nantes, France), Isabelle Portal (CHU Timone, Marseille, France), Thông Dao (Hôpital de la Côte de Nacre, Caen, France), Moana Gelu-Simeon, Marie-Josée Lafrance, Lucie Catherine (CHU de Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe). Methodology and Coordinating Centre Fabrice Carrat (coordinator), Frederic Chau, Céline Dorival, Isabelle Goderel, Clovis Lusivika-Nzinga, Jonathan Bellet, Jessica Chane-Teng, Grégory Pannetier, Jérôme Nicol (Sorbonne University & INSERM U1136—IPLESP, Paris, France). Sponsor Carole Cagnot, Anaïs Boston, Laura Nailler, Guillaume Le Meut, Cécile Moins, Elise Landry (INSERM-ANRS-MIE, Paris, France), Alpha Diallo (Pharmacovigilance coordinator), Ventzislava Petrov-Sanchez (coordinator). Scientific Committee Marc Bourlière (Hôpital St Joseph, Marseille), Jérôme Boursier (CHU Angers, Angers, France), Fabrice Carrat (Scientific Coordinator, Hôpital Saint-Antoine, Paris, France), Patrizia Carrieri (INSERM U912, Marseille, France), Elisabeth Delarocque-Astagneau (Inserm UMR1181, Paris), Victor De Ledinghen (Hôpital Haut-Lévêque, Pessac, Bordeaux, France), Céline Dorival (UPMC & INSERM U1136, Paris, France), Hélène Fontaine (Hôpital Cochin, Paris, France), Slim Fourati (Hôpital Henri Mondor, Créteil, France), Chantal Housset (Inserm UMR-S938 1 IFR65, Paris), Dominique Larrey (Hôpital Saint Eloi, Montpellier, France), Pierre Nahon (Hôpital Jean Verdier, Bondy, France), Georges-Philippe Pageaux (Hôpital Saint Eloi, Montpellier, France), Ventzislava Petrov-Sanchez (ANRS, Paris, France), Stanislas Pol (Principal Investigator, Hôpital Cochin, Paris, France), Mathias Bruyand (Agence Nationale de Santé Publique, Saint Maurice, France), Linda Wittkop (ISPED-INSERM U897, Bordeaux, France), Fabien Zoulim (Hospices Civils de Lyon, Lyon, France), Jessica Zucman-Rossi (Inserm U674/1162, Paris). C écile Brouard (Agence Nationale de Santé Publique, Saint Maurice, France), Frederic Chau, Isabelle Goderel, Clovis Lusivika-Nzinga, Jonathan Bellet, Jessica Chane-Teng, Grégory Pannetier, Jérôme Nicol (Sorbonne University & INSERM U1136—IPLESP, Paris, France). Marianne L’hennaff (ARCAT-TRT-5-CHV, France), Michèle Sizorn (SOS hépatites, France); one representative from the INSERM-ANRS-MIE Pharmacovigilance team, Paris, France (Anaïs Boston, Alpha Diallo), Carole Cagnot (INSERM-ANRS-MIE, Paris, France), one member from Inserm Transfert, Paris, France (Alice Bousselet, Mireille Caralp), and one representative from each pharmaceutical company (MSD, Gilead, Abbvie). Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2023/12
Y1 - 2023/12
N2 - Purpose: Hepatitis C virus (HCV) cure after treatment with direct-acting antivirals (DAAs) can improve health-related quality of life (HRQoL). However, specific groups with chronic HCV may still exhibit worse post-cure HRQoL because of persisting severe liver fibrosis or social vulnerability factors (e.g. unhealthy alcohol use, living in poverty). We assessed the effect of such factors on longitudinal measures of HRQoL in chronic HCV patients. Methods: ANRS CO22 HEPATHER is a prospective cohort of chronic HCV patients receiving DAAs, which included notably patients with social vulnerability factors, a population usually under-represented in clinical trials. Multivariable mixed-effects linear regression models helped identify factors associated with longitudinal measures of HRQoL (PROQOL-HCV scores). Results: At enrolment, 52.4% of the 2740 participants were men, median age was 56 years [interquartile range 50–64], and 21.5% had severe liver fibrosis (FIB-4 > 3.25). Twenty-eight per cent reported current or past unhealthy alcohol use [> 2(3) alcohol units per day for women (men)], and 28.1% were living in poverty (standard of living under 1015€/month per household consumption unit). At first PROQOL-HCV completion, 54.0% of patients were HCV-cured. After multivariable adjustment, people with current or past unhealthy alcohol use, individuals living in poverty, those with severe liver fibrosis, and women had worse HRQoL in the dimensions explored. Conversely, HCV cure was associated with better HRQoL. Conclusions: Specific socially vulnerable groups of patients with chronic HCV infection still experience impaired HRQoL, independently of HCV cure. Patient-centred interventions, including social support and referral for comorbidities, should be prioritized for them. Trial registration with ClinicalTrials.gov NCT01953458.
AB - Purpose: Hepatitis C virus (HCV) cure after treatment with direct-acting antivirals (DAAs) can improve health-related quality of life (HRQoL). However, specific groups with chronic HCV may still exhibit worse post-cure HRQoL because of persisting severe liver fibrosis or social vulnerability factors (e.g. unhealthy alcohol use, living in poverty). We assessed the effect of such factors on longitudinal measures of HRQoL in chronic HCV patients. Methods: ANRS CO22 HEPATHER is a prospective cohort of chronic HCV patients receiving DAAs, which included notably patients with social vulnerability factors, a population usually under-represented in clinical trials. Multivariable mixed-effects linear regression models helped identify factors associated with longitudinal measures of HRQoL (PROQOL-HCV scores). Results: At enrolment, 52.4% of the 2740 participants were men, median age was 56 years [interquartile range 50–64], and 21.5% had severe liver fibrosis (FIB-4 > 3.25). Twenty-eight per cent reported current or past unhealthy alcohol use [> 2(3) alcohol units per day for women (men)], and 28.1% were living in poverty (standard of living under 1015€/month per household consumption unit). At first PROQOL-HCV completion, 54.0% of patients were HCV-cured. After multivariable adjustment, people with current or past unhealthy alcohol use, individuals living in poverty, those with severe liver fibrosis, and women had worse HRQoL in the dimensions explored. Conversely, HCV cure was associated with better HRQoL. Conclusions: Specific socially vulnerable groups of patients with chronic HCV infection still experience impaired HRQoL, independently of HCV cure. Patient-centred interventions, including social support and referral for comorbidities, should be prioritized for them. Trial registration with ClinicalTrials.gov NCT01953458.
KW - Alcohol
KW - Direct-acting antivirals
KW - HCV cure
KW - Health-related quality of life
KW - Hepatitis C virus
KW - Vulnerable population
UR - http://www.scopus.com/inward/record.url?scp=85168087189&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s11136-023-03496-w
DO - https://doi.org/10.1007/s11136-023-03496-w
M3 - Article
C2 - 37587323
SN - 0962-9343
VL - 32
SP - 3427
EP - 3438
JO - Quality of life research
JF - Quality of life research
IS - 12
ER -