TY - JOUR
T1 - Effects of pulsed dye laser treatment in psoriasis
T2 - A nerve-wrecking process?
AU - Doppegieter, Meagan
AU - van der Beek, Nick
AU - Bakker, Erik N. T. P.
AU - Neumann, Martino H. A.
AU - van Bavel, Ed
N1 - Funding Information: We would like to thank L.S. Wilk, Dr. H. B. Thio, Prof. Dr. M.C.G. Aalders and Prof. Dr. T.G. van Leeuwen for their critical reading of this manuscript and useful suggestions. The collaboration project is co‐funded by the PPP Allowance made available by Health~Holland, Top Sector Life Sciences & Health, to stimulate public‐private partnerships (Grant No. 23385). Publisher Copyright: © 2023 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.
PY - 2023/7
Y1 - 2023/7
N2 - Pulsed dye laser (PDL) therapy can be effective in treating psoriasis, with a long duration of remission. Although PDL therapy, albeit on a modest scale, is being used for decades now, the underlying mechanisms responsible for the long-term remission of psoriasis remain poorly understood. The selective and rapid absorption of energy by the blood causes heating of the vascular wall and surrounding structures, like perivascular nerves. Several studies indicate the importance of nerves in psoriatic inflammation. Interestingly, denervation leads to a spontaneous remission of the psoriatic lesion. Among all dermal nerves, the perivascular nerves are the most likely to be affected during PDL treatment, possibly impairing the neuro-inflammatory processes that promote T-cell activation, expression of adhesion molecules, leukocyte infiltration and cytokine production. Repeated PDL therapy could cause a prolonged loss of innervation through nerve damage, or result in a ‘reset’ of neurogenic inflammation after temporary denervation. The current hypothesis provides strong arguments that PDL treatment affects nerve fibres in the skin and thereby abrogates the persistent and exaggerated inflammatory process underlying psoriasis, causing a long-term remission of psoriasis.
AB - Pulsed dye laser (PDL) therapy can be effective in treating psoriasis, with a long duration of remission. Although PDL therapy, albeit on a modest scale, is being used for decades now, the underlying mechanisms responsible for the long-term remission of psoriasis remain poorly understood. The selective and rapid absorption of energy by the blood causes heating of the vascular wall and surrounding structures, like perivascular nerves. Several studies indicate the importance of nerves in psoriatic inflammation. Interestingly, denervation leads to a spontaneous remission of the psoriatic lesion. Among all dermal nerves, the perivascular nerves are the most likely to be affected during PDL treatment, possibly impairing the neuro-inflammatory processes that promote T-cell activation, expression of adhesion molecules, leukocyte infiltration and cytokine production. Repeated PDL therapy could cause a prolonged loss of innervation through nerve damage, or result in a ‘reset’ of neurogenic inflammation after temporary denervation. The current hypothesis provides strong arguments that PDL treatment affects nerve fibres in the skin and thereby abrogates the persistent and exaggerated inflammatory process underlying psoriasis, causing a long-term remission of psoriasis.
KW - perivascular nerves
KW - psoriasis
KW - pulsed dye laser
UR - http://www.scopus.com/inward/record.url?scp=85153472999&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/exd.14816
DO - https://doi.org/10.1111/exd.14816
M3 - Article
C2 - 37083107
SN - 0906-6705
VL - 32
SP - 1165
EP - 1173
JO - Experimental dermatology
JF - Experimental dermatology
IS - 7
ER -