TY - JOUR
T1 - Accuracy and precision of depth-resolved estimation of attenuation coefficients in optical coherence tomography
AU - Neubrand, Linda B.
AU - van Leeuwen, Ton G.
AU - Faber, Dirk J.
N1 - Funding Information: This publication is part of the project “An integrated Optical Coherence Tomography system for medical imaging at 1300 nm” (with project number 16251) of the research program HTSM2017, which is partly financed by the Dutch Research Council (NWO). Publisher Copyright: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
PY - 2023/6/1
Y1 - 2023/6/1
N2 - Significance: Parametric imaging of the attenuation coefficient μ OCT using optical coherence tomography (OCT) is a promising approach for evaluating abnormalities in tissue. To date, a standardized measure of accuracy and precision of μ OCT by the depth-resolved estimation (DRE) method, as an alternative to least squares fitting, is missing. Aim: We present a robust theoretical framework to determine accuracy and precision of the DRE of μOCT. Approach: We derive and validate analytical expressions for the accuracy and precision of μOCT determination by the DRE using simulated OCT signals in absence and presence of noise. We compare the theoretically achievable precisions of the DRE method and the least-squares fitting approach. Results: Our analytical expressions agree with the numerical simulations for high signal-to-noise ratios and qualitatively describe the dependence on noise otherwise. A commonly used simplification of the DRE method results in a systematic overestimation of the attenuation coefficient in the order of μ2 OCT ×, where is the pixel stepsize. When μOCT • AFR 1.8, μOCT is reconstructed with higher precision by the depth-resolved method compared to fitting over the length of an axial fitting range AFR. Conclusions: We derived and validated expressions for the accuracy and precision of DRE of μOCT. A commonly used simplification of this method is not recommended as being used for OCT-attenuation reconstruction. We give a rule of thumb providing guidance in the choice of estimation method.
AB - Significance: Parametric imaging of the attenuation coefficient μ OCT using optical coherence tomography (OCT) is a promising approach for evaluating abnormalities in tissue. To date, a standardized measure of accuracy and precision of μ OCT by the depth-resolved estimation (DRE) method, as an alternative to least squares fitting, is missing. Aim: We present a robust theoretical framework to determine accuracy and precision of the DRE of μOCT. Approach: We derive and validate analytical expressions for the accuracy and precision of μOCT determination by the DRE using simulated OCT signals in absence and presence of noise. We compare the theoretically achievable precisions of the DRE method and the least-squares fitting approach. Results: Our analytical expressions agree with the numerical simulations for high signal-to-noise ratios and qualitatively describe the dependence on noise otherwise. A commonly used simplification of the DRE method results in a systematic overestimation of the attenuation coefficient in the order of μ2 OCT ×, where is the pixel stepsize. When μOCT • AFR 1.8, μOCT is reconstructed with higher precision by the depth-resolved method compared to fitting over the length of an axial fitting range AFR. Conclusions: We derived and validated expressions for the accuracy and precision of DRE of μOCT. A commonly used simplification of this method is not recommended as being used for OCT-attenuation reconstruction. We give a rule of thumb providing guidance in the choice of estimation method.
KW - Cramér-Rao lower bound
KW - OCT signal simulation
KW - attenuation coefficient
KW - curve-fitting
KW - depth resolved estimation
KW - optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=85163905075&partnerID=8YFLogxK
U2 - https://doi.org/10.1117/1.JBO.28.6.066001
DO - https://doi.org/10.1117/1.JBO.28.6.066001
M3 - Article
C2 - 37325192
SN - 1083-3668
VL - 28
SP - 066001
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 6
M1 - 066001
ER -