Neural organoids as preclinical tools for viral infection and gene therapy: Insights from enterovirus D68 and adeno associated virus studies

Viruses causes neurological diseases, but are also used for drug delivery into the central nervous system (CNS), e.g. in gene therapy. The current preclinical models that are used to investigate viral CNS disease pathogenesis and to develop virus-based gene therapies, are limited in translation to the human patient. As an alternative, neural organoids are increasingly being